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Conserved domains on  [gi|1958789215|ref|XP_038934965|]
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host cell factor 2 isoform X1 [Rattus norvegicus]

Protein Classification

Kelch domain-containing protein( domain architecture ID 1002449)

Kelch domain-containing protein is a protein that contains one or more kelch domains which play a role in a variety of cellular processes, including cell signaling, transcription regulation, and protein degradation.

Gene Ontology:  GO:0016567|GO:0080028
PubMed:  31442578|24959344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 3.70e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.90  E-value: 3.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055    80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055   144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055   200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                  ....*
gi 1958789215 328 YFWSG 332
Cdd:COG3055   255 YVIGG 259
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 8.86e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 8.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958789215 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 3.70e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.90  E-value: 3.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055    80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055   144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055   200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                  ....*
gi 1958789215 328 YFWSG 332
Cdd:COG3055   255 YVIGG 259
PLN02193 PLN02193
nitrile-specifier protein
 2-262 4.19e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 65.75  E-value: 4.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 152 SNNNVPRylndfyelelqhgsgvvGWSVPATkgtvpsPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958789215 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.32e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.32e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958789215 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 8.86e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 8.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958789215 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 3.70e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.90  E-value: 3.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  91 VEY---GRYSNELYELQASRWLWKKVkpqpppsGLPPCPRLGHSFSLYGNKCYLFAGlanesedsnNNVPRYLNDFYELE 167
Cdd:COG3055    80 TGAnpsSTPLNDVYVYDPATNTWTKL-------APMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 168 LQHGSgvvgWSvpaTKGTVPSPRESHTAVIyckrdSGSPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPRSL 247
Cdd:COG3055   144 PATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 248 HTASVIGNKMYIFGGwvphkgentENSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGTRL 327
Cdd:COG3055   200 HAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDGKV 254


                  ....*
gi 1958789215 328 YFWSG 332
Cdd:COG3055   255 YVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
9-264 2.29e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 82.90  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG-----GNEGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTR 83
Cdd:COG3055    50 WSELAPLPGP---PRHHAAAVAQDGKLYVFGGftganPSSTPLNDVYVYDPATNTWT---KLAPMPTPRGGATALLLDGK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  84 ILVFGGMVEYGRYSN-ELYELQASRWlwKKVKPQPPPsglppcpRLGHS-FSLYGNKCYLFAGlANESEDSNNnvpryln 161
Cdd:COG3055   124 IYVVGGWDDGGNVAWvEVYDPATGTW--TQLAPLPTP-------RDHLAaAVLPDGKILVIGG-RNGSGFSNT------- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 162 dfyelelqhgsgvvgWSvpaTKGTVPSPRESHTAVIYckrdsgSPKMYVFGGMCGArLDDLWQLDLETMSWSkpeTKGTV 241
Cdd:COG3055   187 ---------------WT---TLAPLPTARAGHAAAVL------GGKILVFGGESGF-SDEVEAYDPATNTWT---ALGEL 238

                         250       260
                  ....*....|....*....|...
gi 1958789215 242 PLPRSLHTASVIGNKMYIFGGWV 264
Cdd:COG3055   239 PTPRHGHAAVLTDGKVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
134-335 1.03e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.89  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 134 LYGNKCYLFAGLANESedsnnnvprYLNDFYELELQHGSgvvgWSvpaTKGTVPSPRESHTAVIYckrDSGspKMYVFGG 213
Cdd:COG3055    20 LLDGKVYVAGGLSGGS---------ASNSFEVYDPATNT----WS---ELAPLPGPPRHHAAAVA---QDG--KLYVFGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 214 MCGAR-----LDDLWQLDLETMSWSKpetKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGentensphdcewrcTSSFSY 288
Cdd:COG3055    79 FTGANpsstpLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGN--------------VAWVEV 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958789215 289 LNLDTAEWTTLVSDsqedkknsrPRPRAGHCA-VAIGTRLYFWSGRDG 335
Cdd:COG3055   142 YDPATGTWTQLAPL---------PTPRDHLAAaVLPDGKILVIGGRNG 180
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-336 1.50e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.50  E-value: 1.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  66 GDIP-PGCAAHGFVCDGtRILVFGGMvEYGRYSN--ELYELQASRWlwkkvkpqpPPSGLPPCPRLGHSFS-LYGNKCYL 141
Cdd:COG3055     7 PDLPtPRSEAAAALLDG-KVYVAGGL-SGGSASNsfEVYDPATNTW---------SELAPLPGPPRHHAAAvAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 142 FAGLaneseDSNNNVPRYLNDFYELELQHGSgvvgWSvpaTKGTVPSPRESHTAVIYckrdsgSPKMYVFGGMCGA-RLD 220
Cdd:COG3055    76 FGGF-----TGANPSSTPLNDVYVYDPATNT----WT---KLAPMPTPRGGATALLL------DGKIYVVGGWDDGgNVA 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 221 DLWQLDLETMSWSkpeTKGTVPLPRSLHTASVIGN-KMYIFGGwvphkgentensphdcewrcTSSFSYLNldtaEWTTL 299
Cdd:COG3055   138 WVEVYDPATGTWT---QLAPLPTPRDHLAAAVLPDgKILVIGG--------------------RNGSGFSN----TWTTL 190

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1958789215 300 vsdsqedkkNSRPRPRAGHCAVAIGTRLYFWSGRDGY 336
Cdd:COG3055   191 ---------APLPTARAGHAAAVLGGKILVFGGESGF 218
PLN02193 PLN02193
nitrile-specifier protein
 2-262 4.19e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 65.75  E-value: 4.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 152 SNNNVPRylndfyelelqhgsgvvGWSVPATkgtvpsPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958789215 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
PLN02153 PLN02153
epithiospecifier protein
 16-264 1.74e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.00  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  16 TGPVPRARHGHRAVAirELMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAHGFVCDGTRILVFGGMV 91
Cdd:PLN02153   18 KGPGPRCSHGIAVVG--DKLYSFGGElkpNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  92 EYGRYSN-ELYELQASRWLWkkvkPQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLaneSEDSNNNVPRYLNDFYELELQH 170
Cdd:PLN02153   96 EKREFSDfYSYDTVKNEWTF----LTKLDEEGGPEARTFHSMASDENHVYVFGGV---SKGGLMKTPERFRTIEAYNIAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 171 GsgvvGWSvpatkgTVPSPRESHTA--------------VIYCKRDSGSPkmyvfGGMCGARLDDLWQLDLETMSWSKPE 236
Cdd:PLN02153  169 G----KWV------QLPDPGENFEKrggagfavvqgkiwVVYGFATSILP-----GGKSDYESNAVQFFDPASGKWTEVE 233

                         250       260
                  ....*....|....*....|....*...
gi 1958789215 237 TKGTVPLPRSLHTASVIGNKMYIFGGWV 264
Cdd:PLN02153  234 TTGAKPSARSVFAHAVVGKYIIIFGGEV 261
PLN02153 PLN02153
epithiospecifier protein
 17-268 3.54e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.76  E-value: 3.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  17 GPVPR-ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW-FLPAVrgDIPPGCAA---HGFVCDGTRILVFGGM 90
Cdd:PLN02153   69 GDVPRiSCLGVRMVAVGTKLYIFGGRDEKREfSDFYSYDTVKNEWtFLTKL--DEEGGPEArtfHSMASDENHVYVFGGV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  91 VEYG------RYSN-ELYELQASRWLwkkvkpQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESedsnnnVPRYLNDF 163
Cdd:PLN02153  147 SKGGlmktpeRFRTiEAYNIADGKWV------QLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSI------LPGGKSDY 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 164 YELELQHGSGVVG-WSVPATKGTVPSPRE--SHTAViyckrdsgSPKMYVFGGMC----------GARLDDLWQLDLETM 230
Cdd:PLN02153  215 ESNAVQFFDPASGkWTEVETTGAKPSARSvfAHAVV--------GKYIIIFGGEVwpdlkghlgpGTLSNEGYALDTETL 286

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958789215 231 SWSKPETKGTVPLPR---SLHTASVIG-NKMYIFGGWVPHKG 268
Cdd:PLN02153  287 VWEKLGECGEPAMPRgwtAYTTATVYGkNGLLMHGGKLPTNE 328
PLN02193 PLN02193
nitrile-specifier protein
 232-375 5.22e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.65  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGgwvphkGENTENSPHDcewrctSSFSYLNLDTAEWTtlVSDSQEDKKNSR 311
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFG------GEFTPNQPID------KHLYVFDLETRTWS--ISPATGDVPHLS 218

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789215 312 PrprAGHCAVAIGTRLYFWSGRDGYKK--ALNSQVCCKDLWYLDT--EKPPAPSQVQLIKATTNSFHV 375
Cdd:PLN02193  219 C---LGVRMVSIGSTLYVFGGRDASRQynGFYSFDTTTNEWKLLTpvEEGPTPRSFHSMAADEENVYV 283
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.32e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.32e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958789215 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PLN02193 PLN02193
nitrile-specifier protein
 77-262 1.92e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 50.72  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215  77 FVCDGTRILVFggmveYGRYSNELYELQASRWL---------WKKVKPQPPPSGLppcpRLGHSFSLYGNKCYLFAGlan 147
Cdd:PLN02193  116 FVLQGGKIVGF-----HGRSTDVLHSLGAYISLpstpkllgkWIKVEQKGEGPGL----RCSHGIAQVGNKIYSFGG--- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 148 eSEDSNNNVPRYLNDFyELELQhgsgvvGWSVPATKGTVPspresHTAVIYCKRDSGSPKMYVFGGMCGAR-LDDLWQLD 226
Cdd:PLN02193  184 -EFTPNQPIDKHLYVF-DLETR------TWSISPATGDVP-----HLSCLGVRMVSIGSTLYVFGGRDASRqYNGFYSFD 250

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958789215 227 LETMSWS--KPETKGtvPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  251 TTTNEWKllTPVEEG--PTPRSFHSMAADEENVYVFGG 286
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
8-104 1.08e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 47.46  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215   8 NWRRVSSFtgPVPRARHGHRAVAIRelmIIFGGGNEGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTRILVF 87
Cdd:COG3055   186 TWTTLAPL--PTARAGHAAAVLGGK---ILVFGGESGFSDEVEAYDPATNTWT---ALGELPTPRHGHAAVLTDGKVYVI 257

                          90
                  ....*....|....*..
gi 1958789215  88 GGMVEYGRYSNELYELQ 104
Cdd:COG3055   258 GGETKPGVRTPLVTSAE 274
PRK14131 PRK14131
N-acetylneuraminate epimerase;
9-89 1.16e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 48.09  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG----GNEG---IADELHVYNTVTNQWFLPAVRGdiPPGCAAH-GFVCD 80
Cdd:PRK14131   64 WTKIAAFPGG---PREQAVAAFIDGKLYVFGGigktNSEGspqVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHvAVSLH 138


                  ....*....
gi 1958789215  81 GTRILVFGG 89
Cdd:PRK14131  139 NGKAYITGG 147
Kelch_3 pfam13415
Galactose oxidase, central domain;
254-323 3.36e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.81  E-value: 3.36e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 254 GNKMYIFGGWVPHKGEntensphdcewrCTSSFSYLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAI 323
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT------------RLNDLYVYDLDTNTWTQI---------GDLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 232-334 4.90e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 42.67  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 232 WSKPETKG-TVPLPRSLHTASVIGNKMYIFGGwvphkgENTENSPHDcewrctSSFSYLNLDTAEWttlvsdSQEDKKNS 310
Cdd:PLN02153    9 WIKVEQKGgKGPGPRCSHGIAVVGDKLYSFGG------ELKPNEHID------KDLYVFDFNTHTW------SIAPANGD 70

                          90       100
                  ....*....|....*....|....*
gi 1958789215 311 RPRPRA-GHCAVAIGTRLYFWSGRD 334
Cdd:PLN02153   71 VPRISClGVRMVAVGTKLYIFGGRD 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 244-301 5.77e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 5.77e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958789215 244 PRSLHTASVIGNKMYIFGGWvphkgentensphdCEWRCTSSFSYLNLDTAEWTTLVS 301
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF--------------DGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 8.86e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 8.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958789215 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
231-337 1.13e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.29  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789215 231 SWSkpeTKGTVPLPRSLHTASVIGNKMYIFGGWVphkgentensphdcEWRCTSSFSYLNLDTAEWTTLVSDSQEdkkns 310
Cdd:COG3055     2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLS--------------GGSASNSFEVYDPATNTWSELAPLPGP----- 59

                          90       100
                  ....*....|....*....|....*..
gi 1958789215 311 rprPRAGHCAVAIGTRLYFWSGRDGYK 337
Cdd:COG3055    60 ---PRHHAAAVAQDGKLYVFGGFTGAN 83
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 187-229 1.21e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958789215 187 PSPRESHTAVIYckrdsgSPKMYVFGGMCGAR---LDDLWQLDLET 229
Cdd:pfam13854   1 PVPRYGHCAVTV------GDYIYLYGGYTGGEgqpSDDVYVLSLPT 40
Kelch_4 pfam13418
Galactose oxidase, central domain;
189-234 2.26e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 2.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958789215 189 PRESHTAViYCKRDSGspkmYVFGGMC--GARLDDLWQLDLETMSWSK 234
Cdd:pfam13418   1 PRAYHTST-SIPDDTI----YLFGGEGedGTLLSDLWVFDLSTNEWTR 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 22-59 3.83e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 3.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958789215  22 ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW 59
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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