F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958790477 104 GDRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWH 150
Cdd:cd22119     1 GQRLPPEILVKIFQFAVATEGAVPLLCRLSRVCRLWREVALDPSLWT 47

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958790477 104 GDRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWH 150
Cdd:cd22119     1 GQRLPPEILVKIFQFAVATEGAVPLLCRLSRVCRLWREVALDPSLWT 47

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958790477 207 VSKFCPRLTFLKLSD---CHGVTAETLVMLAKACCQLHSLDLHHSMVESTAVVSFLEEAGSRMRRLWLTYSSQTT--AIL 281
Cdd:cd09293    99 LATNCPKLQTINLGRhrnGHLITDVSLSALGKNCTFLQTVGFAGCDVTDKGVWELASGCSKSLERLSLNNCRNLTdqSIP 178

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958790477 282 GALLGNCCSQLQVLEVsagmscnntplqlpvealqRGCPQLQ 323
Cdd:cd09293   179 AILASNYFPNLSVLEF-------------------RGCPLIT 201

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958790477 104 GDRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWH 150
Cdd:cd22119     1 GQRLPPEILVKIFQFAVATEGAVPLLCRLSRVCRLWREVALDPSLWT 47

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958790477 105 DRIPLEVLVHIFGLLvaahgPMPFLGRAARVCRHWHEATSHPSLWHTVTLSP 156
Cdd:cd22104     2 ANLPSVVLVHIFSYL-----PPRDRLRASSTCRRWREALFHPSLWRSLRLHL 48

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958790477 112 LVHIFGLLvaahGPMPFLGRAARVCRHWHEATSHPSLWHTVT 153
Cdd:cd22163     9 LMHIFSFL----TPLPDRFNAARVCKRWRALALDPRSWLRVK 46

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958790477 105 DRIPLEVLVHIFgllvaAHGPMPFLGRAARVCRHWHEATSHPSLWHTV 152
Cdd:cd22151     1 RKLPDDLLQEIF-----KRLDPKSLARAACVCRRWRAAARSESLWENA 43

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958790477 105 DRIPLEVLVHIFGLLVAAHgpmpfLGRAARVCRHWHEATSHPSLWHTV 152
Cdd:cd22120     2 DRLPDDVILQIFSHLPTNQ-----LCRCARVCRRWYNLAWDPRLWTTI 44

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958790477 105 DRIPLEVLVHIFGLLVAAHgpmpfLGRAARVCRHWHEATSHPSLWHT 151
Cdd:cd22091     2 EELPDEVLLKIFSYLLEQD-----LCRAAQVCKRFNTLANDPELWKR 43

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958790477 105 DRIPLEVLVHIFGLLVAAHGpmpflGRAARVCRHWHEATSHPSLWHTV 152
Cdd:cd22138     2 QSLPVECQLKIFSFLSEVDK-----CLAATVCRSWSELIRSPRLWRTV 44

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20
                  ....*....|....*....|.
gi 1958790477 129 LGRAARVCRHWHEATSHPSLW 149
Cdd:cd22109    23 LLRCAEVCREWRDVSRHPALW 43