beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794887   1 MRSINDQVLFVDKRNPPVFEDMPDIDRtaNESQTRLIIYMYKDSEV-RGLAVTLSV-KDGRMSTLSCK-NKIISFEEMNP 77
Cdd:cd23298     7 IRNKDNKFLVLDPDGQFVFEDLTDQEL--NAPDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIRFKEMDL 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794887  78 PENIDDIKSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLVLKRKDENGDKSVMFTL 141
Cdd:cd23298    85 PDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794887   1 MRSINDQVLFVDKRNPPVFEDMPDIDRtaNESQTRLIIYMYKDSEV-RGLAVTLSV-KDGRMSTLSCK-NKIISFEEMNP 77
Cdd:cd23298     7 IRNKDNKFLVLDPDGQFVFEDLTDQEL--NAPDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIRFKEMDL 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794887  78 PENIDDIKSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLVLKRKDENGDKSVMFTL 141
Cdd:cd23298    85 PDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958794887   49 LAVTLSVKDGRMsTLSCKNK----IISFEEMNPPENIDDiKSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDD 120
Cdd:smart00125  54 IPVTLGISGTNL-YLSCVKKgdepTLQLEMVDPPKYPKK-EMEKRFVFEKHEIGNKVEFESAAHPNWFISTSQEED 127

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794887   1 MRSINDQVLFVDKRNPPVFEDMPDIDRtaNESQTRLIIYMYKDSEV-RGLAVTLSV-KDGRMSTLSCK-NKIISFEEMNP 77
Cdd:cd23298     7 IRNKDNKFLVLDPDGQFVFEDLTDQEL--NAPDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIRFKEMDL 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958794887  78 PENIDDIKSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLVLKRKDENGDKSVMFTL 141
Cdd:cd23298    85 PDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794887   1 MRSINDQVLFVDKRNPPVFEDMpdidrTANESQTRLIIYMYKDSEV---RGLAVTLSVKDGrMSTLSC----KNKIISFE 73
Cdd:cd00100     7 IRDSNDKSLYLRGNNELVAEDL-----SDVEKSAKITIYYYKSDSDedfKGIPVVLNFTGT-NCFLSCvkegDKPSLQLE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794887  74 EMNPPE--NIDDIKSDLIFFQKRVPGhNKMEFESSLYEGHFLACQKEDdafKLVLKRKDENgDKSVMFTL 141
Cdd:cd00100    81 ECNKEElkNGDEEEWPFVFYMKASHD-NTCRFESAAHPGWFICTKKDQ---PVGLTKELGK-TEDTDFYF 145

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958794887  38 IYMYKDSE-VRGLAVTLSVKDGRMSTLSCK-NKIISFEEMNP-PENIDDIKSDLIFFQKRvpgHNKMEFESSLYEGHFLA 114
Cdd:cd23295    46 IGAYKSLDdDYKIPVTLRISNTQLFVSAQGeDEPVLLKEMPEtPKTITGSETNLLFFWEE---HGTKNFFSSAANPELFA 122

                  ....*.
gi 1958794887 115 CQKEDD 120
Cdd:cd23295   123 ATKQDE 128