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Conserved domains on  [gi|1958795891|ref|XP_038937269|]
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centrosomal protein of 57 kDa isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cep57_CLD super family cl26051
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 1-95 1.20e-37

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


The actual alignment was detected with superfamily member pfam14073:

Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 133.14  E-value: 1.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891   1 MRNMIKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQA 80
Cdd:pfam14073  83 MRKMVENAEKERTAVLEKQASLERERSQDSSELQAQLEKLEKLEQEYLRLTRTQSLAETKIKELEEKLQEEEHQRKLVQE 162

                          90
                  ....*....|....*
gi 1958795891  81 RAAELQSGIEANRLI 95
Cdd:pfam14073 163 KAAQLQTGLETNRIL 177
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 202-271 4.69e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


:

Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 72.22  E-value: 4.69e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795891 202 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 271
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
 
Name Accession Description Interval E-value
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 1-95 1.20e-37

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 133.14  E-value: 1.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891   1 MRNMIKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQA 80
Cdd:pfam14073  83 MRKMVENAEKERTAVLEKQASLERERSQDSSELQAQLEKLEKLEQEYLRLTRTQSLAETKIKELEEKLQEEEHQRKLVQE 162

                          90
                  ....*....|....*
gi 1958795891  81 RAAELQSGIEANRLI 95
Cdd:pfam14073 163 KAAQLQTGLETNRIL 177
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 202-271 4.69e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 72.22  E-value: 4.69e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795891 202 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 271
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-93 3.20e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891    3 NMIKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLT-------AMQALAEKKMQELESKLHEEEQER 75
Cdd:TIGR02168  302 QQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKeelesleAELEELEAELEELESRLEELEEQL 381

                           90
                   ....*....|....*...
gi 1958795891   76 KRMQARAAELQSGIEANR 93
Cdd:TIGR02168  382 ETLRSKVAQLELQIASLN 399
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 5-93 3.91e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891   5 IKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAE 84
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376


                  ....*....
gi 1958795891  85 LQSGIEANR 93
Cdd:COG1196   377 AEEELEELA 385
PRK09039 PRK09039
peptidoglycan -binding protein;
16-93 1.45e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 39.95  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891  16 LEKQVSLERERQHDQSHVQSQL-------EKL-DLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQS 87
Cdd:PRK09039   65 LADLLSLERQGNQDLQDSVANLraslsaaEAErSRLQALLAELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELLNQ 144


                  ....*.
gi 1958795891  88 GIEANR 93
Cdd:PRK09039  145 QIAALR 150
 
Name Accession Description Interval E-value
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 1-95 1.20e-37

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 133.14  E-value: 1.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891   1 MRNMIKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQA 80
Cdd:pfam14073  83 MRKMVENAEKERTAVLEKQASLERERSQDSSELQAQLEKLEKLEQEYLRLTRTQSLAETKIKELEEKLQEEEHQRKLVQE 162

                          90
                  ....*....|....*
gi 1958795891  81 RAAELQSGIEANRLI 95
Cdd:pfam14073 163 KAAQLQTGLETNRIL 177
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 202-271 4.69e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 72.22  E-value: 4.69e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795891 202 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 271
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-93 3.20e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891    3 NMIKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLT-------AMQALAEKKMQELESKLHEEEQER 75
Cdd:TIGR02168  302 QQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKeelesleAELEELEAELEELESRLEELEEQL 381

                           90
                   ....*....|....*...
gi 1958795891   76 KRMQARAAELQSGIEANR 93
Cdd:TIGR02168  382 ETLRSKVAQLELQIASLN 399
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 5-93 3.91e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891   5 IKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAE 84
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376


                  ....*....
gi 1958795891  85 LQSGIEANR 93
Cdd:COG1196   377 AEEELEELA 385
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 30-91 1.00e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 1.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958795891  30 QSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQSGIEA 91
Cdd:COG1196   238 EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELAR 299
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-93 1.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891   2 RNMIKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQAR 81
Cdd:COG1196   308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE 387

                          90
                  ....*....|..
gi 1958795891  82 AAELQSGIEANR 93
Cdd:COG1196   388 LLEALRAAAELA 399
PRK09039 PRK09039
peptidoglycan -binding protein;
16-93 1.45e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 39.95  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891  16 LEKQVSLERERQHDQSHVQSQL-------EKL-DLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQS 87
Cdd:PRK09039   65 LADLLSLERQGNQDLQDSVANLraslsaaEAErSRLQALLAELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELLNQ 144


                  ....*.
gi 1958795891  88 GIEANR 93
Cdd:PRK09039  145 QIAALR 150
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 5-86 5.10e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891   5 IKHAEMERTSVLEKQVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAE 84
Cdd:COG1196   241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320


                  ..
gi 1958795891  85 LQ 86
Cdd:COG1196   321 LE 322
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
7-93 9.66e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.97  E-value: 9.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795891    7 HAEMERTsvlEKQV-SLERERQHDQSHvQSQLEKLDLLEQEYNRLTAMQAlaEKKMQELESKLHEEEQERKRMQARAAEL 85
Cdd:COG4913    241 HEALEDA---REQIeLLEPIRELAERY-AAARERLAELEYLRAALRLWFA--QRRLELLEAELEELRAELARLEAELERL 314


                   ....*...
gi 1958795891   86 QSGIEANR 93
Cdd:COG4913    315 EARLDALR 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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