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Conserved domains on  [gi|1958795893|ref|XP_038937270|]
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centrosomal protein of 57 kDa isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cep57_CLD super family cl26051
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 5-95 1.28e-27

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


The actual alignment was detected with superfamily member pfam14073:

Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 106.56  E-value: 1.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795893   5 KRGRTQRMKNQstikVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAE 84
Cdd:pfam14073  91 EKERTAVLEKQ----ASLERERSQDSSELQAQLEKLEKLEQEYLRLTRTQSLAETKIKELEEKLQEEEHQRKLVQEKAAQ 166

                          90
                  ....*....|.
gi 1958795893  85 LQSGIEANRLI 95
Cdd:pfam14073 167 LQTGLETNRIL 177
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 202-271 2.27e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


:

Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 72.99  E-value: 2.27e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795893 202 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 271
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
 
Name Accession Description Interval E-value
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 5-95 1.28e-27

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 106.56  E-value: 1.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795893   5 KRGRTQRMKNQstikVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAE 84
Cdd:pfam14073  91 EKERTAVLEKQ----ASLERERSQDSSELQAQLEKLEKLEQEYLRLTRTQSLAETKIKELEEKLQEEEHQRKLVQEKAAQ 166

                          90
                  ....*....|.
gi 1958795893  85 LQSGIEANRLI 95
Cdd:pfam14073 167 LQTGLETNRIL 177
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 202-271 2.27e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 72.99  E-value: 2.27e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795893 202 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 271
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 30-91 7.79e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 7.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958795893  30 QSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQSGIEA 91
Cdd:COG1196   238 EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELAR 299
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 10-93 1.22e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795893   10 QRMKNQSTIKVSLERERQHDQSHVQSQLEKLDLLEQEYNRLT-------AMQALAEKKMQELESKLHEEEQERKRMQARA 82
Cdd:TIGR02168  309 ERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKeelesleAELEELEAELEELESRLEELEEQLETLRSKV 388

                           90
                   ....*....|.
gi 1958795893   83 AELQSGIEANR 93
Cdd:TIGR02168  389 AQLELQIASLN 399
PRK09039 PRK09039
peptidoglycan -binding protein;
14-93 2.15e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 39.56  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795893  14 NQSTIKVSLERERQHDQSHVQSQL-------EKL-DLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAEL 85
Cdd:PRK09039   63 AELADLLSLERQGNQDLQDSVANLraslsaaEAErSRLQALLAELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELL 142


                  ....*...
gi 1958795893  86 QSGIEANR 93
Cdd:PRK09039  143 NQQIAALR 150
 
Name Accession Description Interval E-value
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 5-95 1.28e-27

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 106.56  E-value: 1.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795893   5 KRGRTQRMKNQstikVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAE 84
Cdd:pfam14073  91 EKERTAVLEKQ----ASLERERSQDSSELQAQLEKLEKLEQEYLRLTRTQSLAETKIKELEEKLQEEEHQRKLVQEKAAQ 166

                          90
                  ....*....|.
gi 1958795893  85 LQSGIEANRLI 95
Cdd:pfam14073 167 LQTGLETNRIL 177
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 202-271 2.27e-16

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 72.99  E-value: 2.27e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795893 202 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 271
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 30-91 7.79e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 7.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958795893  30 QSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQSGIEA 91
Cdd:COG1196   238 EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELAR 299
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 10-93 1.22e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795893   10 QRMKNQSTIKVSLERERQHDQSHVQSQLEKLDLLEQEYNRLT-------AMQALAEKKMQELESKLHEEEQERKRMQARA 82
Cdd:TIGR02168  309 ERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKeelesleAELEELEAELEELESRLEELEEQLETLRSKV 388

                           90
                   ....*....|.
gi 1958795893   83 AELQSGIEANR 93
Cdd:TIGR02168  389 AQLELQIASLN 399
PRK09039 PRK09039
peptidoglycan -binding protein;
14-93 2.15e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 39.56  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795893  14 NQSTIKVSLERERQHDQSHVQSQL-------EKL-DLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAEL 85
Cdd:PRK09039   63 AELADLLSLERQGNQDLQDSVANLraslsaaEAErSRLQALLAELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELL 142


                  ....*...
gi 1958795893  86 QSGIEANR 93
Cdd:PRK09039  143 NQQIAALR 150
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 22-93 4.04e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 4.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958795893  22 LERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQSGIEANR 93
Cdd:COG1196   314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 8-86 4.18e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 4.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795893   8 RTQRMKNQSTIKVSLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQ 86
Cdd:COG1196   307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 21-86 8.45e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.99  E-value: 8.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958795893  21 SLERERQHDQSHVQSQLEKLDLLEQEYNRLTAMQALAEKKMQELESKLHEEEQERKRMQARAAELQ 86
Cdd:COG1196   257 ELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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