NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958795903|ref|XP_038937276|]
View 

centrosomal protein of 57 kDa isoform X5 [Rattus norvegicus]

Protein Classification

Cep57_MT_bd domain-containing protein( domain architecture ID 10535246)

Cep57_MT_bd domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 142-211 1.40e-17

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


:

Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 75.30  E-value: 1.40e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795903 142 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 211
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
Cep57_CLD super family cl26051
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 1-35 5.83e-08

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


The actual alignment was detected with superfamily member pfam14073:

Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 51.47  E-value: 5.83e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958795903   1 MQELESKLHEEEQERKRMQARAAELQSGIEANRLI 35
Cdd:pfam14073 143 IKELEEKLQEEEHQRKLVQEKAAQLQTGLETNRIL 177
 
Name Accession Description Interval E-value
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 142-211 1.40e-17

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 75.30  E-value: 1.40e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795903 142 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 211
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 1-35 5.83e-08

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 51.47  E-value: 5.83e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958795903   1 MQELESKLHEEEQERKRMQARAAELQSGIEANRLI 35
Cdd:pfam14073 143 IKELEEKLQEEEHQRKLVQEKAAQLQTGLETNRIL 177
 
Name Accession Description Interval E-value
Cep57_MT_bd pfam06657
Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, ...
 142-211 1.40e-17

Centrosome microtubule-binding domain of Cep57; This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, pfam14073, is the centrosome localization domain Cep57.


Pssm-ID: 461976 [Multi-domain]  Cd Length: 77  Bit Score: 75.30  E-value: 1.40e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958795903 142 PSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQE---SPSEELKDNLECELEALVRRMEAKANQITKVRKY 211
Cdd:pfam06657   5 PSQSPGEALAEVLKELEDEFEHLKLEYQELAAQYNAldpSLGKRKRKDLAEELEELLKRLEAKADQIYALYDV 77
Cep57_CLD pfam14073
Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is ...
 1-35 5.83e-08

Centrosome localization domain of Cep57; The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.


Pssm-ID: 464080 [Multi-domain]  Cd Length: 178  Bit Score: 51.47  E-value: 5.83e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958795903   1 MQELESKLHEEEQERKRMQARAAELQSGIEANRLI 35
Cdd:pfam14073 143 IKELEEKLQEEEHQRKLVQEKAAQLQTGLETNRIL 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH