second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 204 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 283
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958799398 284 FVCSVLVVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 312 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 371
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 204 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 283
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958799398 284 FVCSVLVVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 312 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 371
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799398   2 DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 80
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLEFMYTGK 73

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799398    6 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 80
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 204 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 283
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958799398 284 FVCSVLVVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 312 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 371
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398   4 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrkdeDAAGCHLFVVEKVHPDLFEYLLQFMYTDTCDF 83
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGM-------------KESSSSEIELDDVSPEAFEALLDYIYTGELEL 67

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 207 FLYDVTMKsVDGKEFPCHKCVLCARLEYFHSML----SRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAVVikesqN 281
Cdd:cd18296    16 SFPDVCFQ-VEGHRFPCHKAFFCGRSDYFKALLrdhfAESEENNGSIPVVTLHdVSPEVFAIVLYYIYTDDTDL-----P 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958799398 282 VDFVCSVLVVADQLLITRLKEMCEVALAENL 312
Cdd:cd18296    90 PENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 198 LKLSQKkcSFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCaalEMPIQA---EILKVILDYLYTDeAV 274
Cdd:cd18286     9 LQLFLN--GEDSDITIK-VDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS---EITLTGvshAAVSFVLLFIYGG-VL 81

                          90       100
                  ....*....|....*....|....*...
gi 1958799398 275 VIKESQNvdfVCSVLVVADQLLITRLKE 302
Cdd:cd18286    82 DLPDDVN---LGELLSLADMYGLDGLKD 106

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799398    6 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 80
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYtDEAVVIKEsqnvDFVCSVL 289
Cdd:cd18265    25 DVVLL-VDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY-GGGLRIQE----DNVESVL 98

                          90       100
                  ....*....|....*....|....*..
gi 1958799398 290 VVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18265    99 EASDLLQVSKLREACVRFLEGQLHPCN 125

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398   1 MDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsDGTLLEltdvyrKDEDAAGCHLFVVEKVHPDLFEYLLQFMYTDT 80
Cdd:cd18296    14 ELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALL--RDHFAE------SEENNGSIPVVTLHDVSPEVFAIVLYYIYTDD 85

                  ..
gi 1958799398  81 CD 82
Cdd:cd18296    86 TD 87

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEavvIKESQNVDFVCsV 288
Cdd:cd18300    11 DVTFI-VEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-KEVELPgVSKETFLALLEYLYTDQ---APILEDGDCVG-L 84

                          90
                  ....*....|....*..
gi 1958799398 289 LVVADQLLITRLKEMCE 305
Cdd:cd18300    85 IVLANRLCLPRLVALCE 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 216 VDGKEFPCHKCVLCARLEYFHSMLSRSW-IEASSCAALE-MPIQAEILKVILDYLYTDEavvIKESQnvDFVCSVLVVAD 293
Cdd:cd18245    21 VGGEEIPVQKNVLAAASPYFRAKLNYNPpKDDGSTYKIElEGISVEVMEEILDYIYTGQ---IKLSE--DNIQDIVQAAD 95

                          90
                  ....*....|.
gi 1958799398 294 QLLITRLKEMC 304
Cdd:cd18245    96 LLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398   3 SFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlSDGTLLELTDVYRkdedaagchlfvVEKVHPDLFEYLLQFMYTDTCD 82
Cdd:cd18256    19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALF-AGGMSESSKDVVQ------------IHGVEPDIFHILLDFIYTGVVE 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958799398  83 FLTHGFKPRMI---MNKKSEDSKGSPE---SRLHAVNC 114
Cdd:cd18256    86 VTVSNVQELLVaadMLQLTEVVEICCEflkGQLHPSNC 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqNVDFvcsVL 289
Cdd:cd18253    20 DVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE--NVQY---LF 93

                          90       100
                  ....*....|....*....|...
gi 1958799398 290 VVADQLLITRLKEMCEVALAENL 312
Cdd:cd18253    94 ETSSLFQISPLRDACAKFLEEQL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 190 IAKKTGNKLKLSQ-KKCSFLydvtmksVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYL 268
Cdd:cd18343     8 LAEDLGNLWENSRfTDCSLF-------VGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958799398 269 YTDEAvvikesQNVDFVC-SVLVVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18343    81 YTGKA------PNLDKMAdNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 208 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKesQNVDfvcS 287
Cdd:cd18236    24 LTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITK--QNVQ---R 97

                          90       100
                  ....*....|....*....|....*....
gi 1958799398 288 VLVVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18236    98 VLEAASLFQFLRMVDACASFLTEALHPEN 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqnvdFVCSVL 289
Cdd:cd18279    20 DCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK-----MADDLL 93

                          90       100
                  ....*....|....*....|....*..
gi 1958799398 290 VVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18279    94 AAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 202 QKKCSFLYDVTM--KSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-------IQAEILKVILDYLYTDE 272
Cdd:cd18241    17 QRKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS-GRVEMRkwssepgPDPDTVEAVIQYMYTGR 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958799398 273 AVVIKESqnvdfVCSVLVVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18241    96 IRVSTGN-----VHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 216 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIkesQNVDFVCSVLVVADQL 295
Cdd:cd18344    30 VAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHL---HSHSMACDVLAAADKY 106

                          90       100
                  ....*....|....*....|..
gi 1958799398 296 LITRLKEMCEVALAENLTLKNA 317
Cdd:cd18344   107 GLEGLKVLCEDALCRNLSVENA 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAVVIKESQnvDFVCSV 288
Cdd:cd18287    24 DVTF-VVEEKRFPAHRVILAARSEYFRALLYGGMRE-SQQSEIELKdTNAEAFKALLKYIYTGRLTLTDLKE--DVLLDV 99

                  ....*.
gi 1958799398 289 LVVADQ 294
Cdd:cd18287   100 LGLAHQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMKSVdGKEFPCHKCVLCaRLEYFHSMLSRSWIEA-SSCAALEMP---IQAEILKVILDYLYTDEaVVIKESQnvdfV 285
Cdd:cd18305    17 DITICAL-GREWKLHKIYLC-QSGYFASMFSGSWKESkETVINLEIPddnITVEALNVVFGSLYRDE-IEIKPSR----V 89

                          90       100
                  ....*....|....*....|....*.
gi 1958799398 286 CSVLVVADQLLITRLKEMCEVALAEN 311
Cdd:cd18305    90 VSILAAATLLQLDGLIQQCSEVMKET 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEAVVIKESQNVDFvcSV 288
Cdd:cd18297    14 DVTFL-VEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQT-PVIEIPdIRYDIFQLMMQYLYTGGVESLDVAQDDAL--EL 89

                          90       100
                  ....*....|....*....|....*...
gi 1958799398 289 LVVADQLLITRLKEMCEVALAENLTLKN 316
Cdd:cd18297    90 LRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 210 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASS-CAALEmPIQAEILKVILDYLYTDE-------AVVIKESQN 281
Cdd:cd18280    16 DVTF-NVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEgEIVIE-DVEPPVFKALLHFIYKDElpddvepAGSDSSSLD 93

                          90       100
                  ....*....|....*....|....*..
gi 1958799398 282 VDFVCSVLVVADQLLITRLKEMCEVAL 308
Cdd:cd18280    94 TTMAQHLLAAADRYALERLRLLCESRL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 205 CSFLYDVTMKSV-------DGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavVIK 277
Cdd:cd18273    23 ARLLTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGR--VTL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958799398 278 ESQNVDfvcSVLVVADQLLITRLKEMCEVALAENLTLKNAAMLL 321
Cdd:cd18273   101 SEANVQ---RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 206 SFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAvvikESQnVDF 284
Cdd:cd18295    17 GSYSDVTF-NVHGESFPAHRCILSARSPYFAEMFETKWKD-KREINLKHPlVNPDAFRALLQYLYTGRL----EIH-VDD 89

                          90       100
                  ....*....|....*....|....
gi 1958799398 285 VCSVLVVADQ----LLITRLKEMC 304
Cdd:cd18295    90 VEDCKRLAKQcrleELIEELEAKC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 208 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKV---ILDYLYTDEAVVikesqNVDF 284
Cdd:cd18292    17 LSDIVLR-VGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVfekFLRYLYTGQISV-----NLET 90

                          90       100
                  ....*....|....*....|.
gi 1958799398 285 VCSVLVVADQLLITRLKEMCE 305
Cdd:cd18292    91 ALPLLMLADKYNVTDLKQLCV 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799398 216 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAvvikesQNVDFVCS-VLVVADQ 294
Cdd:cd18342    29 VAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADdLLAAADK 102