'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958802188 458 KWTSLERKLFNKALATYSKDFIFVQK-MVKSKTVAQCVEYYYTWKK 502
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46

C2H2-type zinc finger;

                          10        20
                  ....*....|....*....|....
gi 1958802188 665 IFPCKECGKVFFKIKSRNAHMKTH 688
Cdd:pfam13912   1 VHECSECGKSFPSYQALGGHKKSH 24

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958802188 458 KWTSLERKLFNKALATYSKDFIFVQK-MVKSKTVAQCVEYYYTWKK 502
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958802188 458 KWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWK 501
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46

C2H2-type zinc finger;

                          10        20
                  ....*....|....*....|....
gi 1958802188 665 IFPCKECGKVFFKIKSRNAHMKTH 688
Cdd:pfam13912   1 VHECSECGKSFPSYQALGGHKKSH 24

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958802188 458 KWTSLERKLFNKALATYSKDFIFVQK-MVKSKTVAQCVEYYYTWKK 502
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958802188 458 KWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWK 501
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958802188 458 KWTSLERKLFNKALATY-SKDFIFVQKMVKSKTVAQCVEYYYTWK 501
Cdd:cd00167     1 PWTEEEDELLLEAVKKYgKNNWEKIAKELPGRTPKQCRERWRNLL 45

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 1958802188 666 FPCKECGKVFFKIKSRNAHMKTH 688
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23