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Conserved domains on  [gi|1958656557|ref|XP_038941153|]
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thymidine kinase, cytosolic isoform X2 [Rattus norvegicus]

Protein Classification

thymidine kinase( domain architecture ID 581102)

thymidine kinase catalyzes the phosphorylation of both thymidine and deoxyuridine

CATH:  3.40.50.300|3.30.60.20
EC:  2.7.1.21
Gene Ontology:  GO:0004797|GO:0005524|GO:0008270
SCOP:  4003437

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TK super family cl23762
Thymidine kinase;
18-70 6.31e-28

Thymidine kinase;


The actual alignment was detected with superfamily member PTZ00293:

Pssm-ID: 451530  Cd Length: 211  Bit Score: 101.34  E-value: 6.31e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958656557  18 RGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNS--FSTHDR 70
Cdd:PTZ00293    3 RGTISVIIGPMFSGKTTELMRLVKRFTYSEKKCVVIKYSKDTRYSDEqnISSHDK 57
 
Name Accession Description Interval E-value
PTZ00293 PTZ00293
thymidine kinase; Provisional
 18-70 6.31e-28

thymidine kinase; Provisional


Pssm-ID: 185542  Cd Length: 211  Bit Score: 101.34  E-value: 6.31e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958656557  18 RGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNS--FSTHDR 70
Cdd:PTZ00293    3 RGTISVIIGPMFSGKTTELMRLVKRFTYSEKKCVVIKYSKDTRYSDEqnISSHDK 57
TK pfam00265
Thymidine kinase;
19-70 1.45e-25

Thymidine kinase;


Pssm-ID: 306721  Cd Length: 176  Bit Score: 94.32  E-value: 1.45e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958656557  19 GQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSN-SFSTHDR 70
Cdd:pfam00265   1 GSIHLIYGPMFSGKSTELIRRVYRYQEAGMKCVVIKYAIDNRYGTgKVVTHDG 53
Tdk COG1435
Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the ...
 19-62 2.32e-16

Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441044  Cd Length: 192  Bit Score: 70.90  E-value: 2.32e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958656557  19 GQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYS 62
Cdd:COG1435     4 GKLEFIYGPMFSGKSEELLRRAHNYEEAGQKVLLFKPAIDDRYG 47
 
Name Accession Description Interval E-value
PTZ00293 PTZ00293
thymidine kinase; Provisional
 18-70 6.31e-28

thymidine kinase; Provisional


Pssm-ID: 185542  Cd Length: 211  Bit Score: 101.34  E-value: 6.31e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958656557  18 RGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNS--FSTHDR 70
Cdd:PTZ00293    3 RGTISVIIGPMFSGKTTELMRLVKRFTYSEKKCVVIKYSKDTRYSDEqnISSHDK 57
TK pfam00265
Thymidine kinase;
19-70 1.45e-25

Thymidine kinase;


Pssm-ID: 306721  Cd Length: 176  Bit Score: 94.32  E-value: 1.45e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958656557  19 GQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSN-SFSTHDR 70
Cdd:pfam00265   1 GSIHLIYGPMFSGKSTELIRRVYRYQEAGMKCVVIKYAIDNRYGTgKVVTHDG 53
Tdk COG1435
Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the ...
 19-62 2.32e-16

Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441044  Cd Length: 192  Bit Score: 70.90  E-value: 2.32e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958656557  19 GQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYS 62
Cdd:COG1435     4 GKLEFIYGPMFSGKSEELLRRAHNYEEAGQKVLLFKPAIDDRYG 47
PRK04296 PRK04296
thymidine kinase; Provisional
 19-62 9.83e-14

thymidine kinase; Provisional


Pssm-ID: 235272  Cd Length: 190  Bit Score: 63.98  E-value: 9.83e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958656557  19 GQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYS 62
Cdd:PRK04296    2 AKLEFIYGAMNSGKSTELLQRAYNYEERGMKVLVFKPAIDDRYG 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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