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Conserved domains on  [gi|1958669138|ref|XP_038945523|]
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cyclin-dependent kinase 2-associated protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDK2AP super family cl10779
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 127-179 9.11e-19

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


The actual alignment was detected with superfamily member pfam09806:

Pssm-ID: 430840  Cd Length: 211  Bit Score: 79.94  E-value: 9.11e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958669138 127 KYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNAR 179
Cdd:pfam09806 159 KYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHARVLVRECLLLLERDQR 211
 
Name Accession Description Interval E-value
CDK2AP pfam09806
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 127-179 9.11e-19

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


Pssm-ID: 430840  Cd Length: 211  Bit Score: 79.94  E-value: 9.11e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958669138 127 KYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNAR 179
Cdd:pfam09806 159 KYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHARVLVRECLLLLERDQR 211
 
Name Accession Description Interval E-value
CDK2AP pfam09806
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 127-179 9.11e-19

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


Pssm-ID: 430840  Cd Length: 211  Bit Score: 79.94  E-value: 9.11e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958669138 127 KYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNAR 179
Cdd:pfam09806 159 KYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHARVLVRECLLLLERDQR 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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