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Conserved domains on  [gi|1958669375|ref|XP_038945608|]
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microtubule-associated tumor suppressor candidate 2 isoform X3 [Rattus norvegicus]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 183-487 1.69e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 1.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  183 QAREAERQLaQRLRDRCEWQARQLGLARRELKKAIQGFDAMAVSAKHFFGKSERALAKEKELSIELANIRDEVAFNTAKC 262
Cdd:TIGR02168  692 KIAELEKAL-AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  263 EKLQKEKEALERRFEEELRRLgwQQQAEVQELQERLQQQFQAESARLQAEHQDQMLRM-RCQHQ-----EQVEDITASHE 336
Cdd:TIGR02168  771 EEAEEELAEAEAEIEELEAQI--EQLKEELKALREALDELRAELTLLNEEAANLRERLeSLERRiaateRRLEDLEEQIE 848

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  337 AALLEMENNhTVAITILQDDHDHKVQELMStHEFEKKELEENFEKLRLSLQDQVDTLtfqsQSLRDRAQRFEEALRKTTE 416
Cdd:TIGR02168  849 ELSEDIESL-AAEIEELEELIEELESELEA-LLNERASLEEALALLRSELEELSEEL----RELESKRSELRRELEELRE 922

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958669375  417 EQleialapyQHLEEDMQSLKQvlEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQ 487
Cdd:TIGR02168  923 KL--------AQLELRLEGLEV--RIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 13-220 9.72e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 9.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   13 KRASN-SNAAKSGLPKSGLRPPGySRLPAAKLAAFGF----------VRSSSVSAVPSTQSLDSAQQEQ----SRPVTRP 77
Cdd:PHA03247  2665 RRARRlGRAAQASSPPQRPRRRA-ARPTVGSLTSLADpppppptpepAPHALVSATPLPPGPAAARQASpalpAAPAPPA 2743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   78 TFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTSTPAGAKKEPQK--------------DPEAKK 143
Cdd:PHA03247  2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDpadppaavlapaaaLPPAAS 2823

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958669375  144 PAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKPDLQAREAERQLAQRLRDRCEWQARQlgLARRELKKAIQGF 220
Cdd:PHA03247  2824 PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR--LARPAVSRSTESF 2898
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 183-487 1.69e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 1.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  183 QAREAERQLaQRLRDRCEWQARQLGLARRELKKAIQGFDAMAVSAKHFFGKSERALAKEKELSIELANIRDEVAFNTAKC 262
Cdd:TIGR02168  692 KIAELEKAL-AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  263 EKLQKEKEALERRFEEELRRLgwQQQAEVQELQERLQQQFQAESARLQAEHQDQMLRM-RCQHQ-----EQVEDITASHE 336
Cdd:TIGR02168  771 EEAEEELAEAEAEIEELEAQI--EQLKEELKALREALDELRAELTLLNEEAANLRERLeSLERRiaateRRLEDLEEQIE 848

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  337 AALLEMENNhTVAITILQDDHDHKVQELMStHEFEKKELEENFEKLRLSLQDQVDTLtfqsQSLRDRAQRFEEALRKTTE 416
Cdd:TIGR02168  849 ELSEDIESL-AAEIEELEELIEELESELEA-LLNERASLEEALALLRSELEELSEEL----RELESKRSELRRELEELRE 922

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958669375  417 EQleialapyQHLEEDMQSLKQvlEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQ 487
Cdd:TIGR02168  923 KL--------AQLELRLEGLEV--RIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 185-528 2.89e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 185 REAERQLAQ------RLRDRCEWQARQLG-LAR--------RELKKAIQGFDAmavsakhffgksERALAKEKELSIELA 249
Cdd:COG1196   175 EEAERKLEAteenleRLEDILGELERQLEpLERqaekaeryRELKEELKELEA------------ELLLLKLRELEAELE 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 250 NIRDEVAFNTAKCEKLQKEKEALERRFEEELRrlgwQQQAEVQELQERLQQQFQAESARLQAEHQDQMLRMRCQHQEQVE 329
Cdd:COG1196   243 ELEAELEELEAELEELEAELAELEAELEELRL----ELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 330 DITASHEAALLEMENNHTVAITILQDDHDHKVQELmsthefekKELEENFEKLRLSLQDQVDTLTFQSQSLRDRAQRFEE 409
Cdd:COG1196   319 EELEEELAELEEELEELEEELEELEEELEEAEEEL--------EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 410 ALRKTTEEQLEIalapyQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQNT 489
Cdd:COG1196   391 ALRAAAELAAQL-----EELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELL 465

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1958669375 490 VVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 528
Cdd:COG1196   466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
PHA03247 PHA03247
large tegument protein UL36; Provisional
 13-220 9.72e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 9.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   13 KRASN-SNAAKSGLPKSGLRPPGySRLPAAKLAAFGF----------VRSSSVSAVPSTQSLDSAQQEQ----SRPVTRP 77
Cdd:PHA03247  2665 RRARRlGRAAQASSPPQRPRRRA-ARPTVGSLTSLADpppppptpepAPHALVSATPLPPGPAAARQASpalpAAPAPPA 2743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   78 TFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTSTPAGAKKEPQK--------------DPEAKK 143
Cdd:PHA03247  2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDpadppaavlapaaaLPPAAS 2823

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958669375  144 PAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKPDLQAREAERQLAQRLRDRCEWQARQlgLARRELKKAIQGF 220
Cdd:PHA03247  2824 PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR--LARPAVSRSTESF 2898
PRK11281 PRK11281
mechanosensitive channel MscK;
373-520 5.83e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.06  E-value: 5.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  373 KELEENFEKLRLSLQDQVDTL--------TFQSQSLRDRAQRFE-------------------EALRKTTEEQLEIALA- 424
Cdd:PRK11281   124 RQLESRLAQTLDQLQNAQNDLaeynsqlvSLQTQPERAQAALYAnsqrlqqirnllkggkvggKALRPSQRVLLQAEQAl 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  425 -----PYQHLE----EDMQSLKQV-LEMKNQQIHLQEKKIIELEKLV-EKNIILEEKiQVLQQQNEDLKARIDQNTVVTR 493
Cdd:PRK11281   204 lnaqnDLQRKSlegnTQLQDLLQKqRDYLTARIQRLEHQLQLLQEAInSKRLTLSEK-TVQEAQSQDEAARIQANPLVAQ 282

                          170       180
                   ....*....|....*....|....*..
gi 1958669375  494 QLsEENANLQEYVEKETQEKKRLSRTN 520
Cdd:PRK11281   283 EL-EINLQLSQRLLKATEKLNTLTQQN 308
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 50-180 3.52e-04

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 43.23  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  50 RSSSVSAVP-----STQSLDSAQQEQS----RPVTRPTFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLP 120
Cdd:pfam13254 196 RPNSFKEVTpvglmRSPAPGGHSKSPSvsgiSADSSPTKEEPSEEADTLSTDKEQSPAPTSASEPPPKTKELPKDSEEPA 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 121 APkstSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKP 180
Cdd:pfam13254 276 AP---SKSAEASTEKKEPDTESSPETSSEKSAPSLLSPVSKASIDKPLSSPDRDPLSPKP 332
Jnk-SapK_ap_N pfam09744
JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...
 417-521 7.46e-04

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.


Pssm-ID: 462875 [Multi-domain]  Cd Length: 150  Bit Score: 40.29  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 417 EQLEIALAPYQHLEEDMQSLKQvlemKNQQIHLQEKKIIELEKLVEKNiiLEEKIQVLQQQNEDLKARIDQNTVVTRQLS 496
Cdd:pfam09744  36 ELLESLASRNQEHNVELEELRE----DNEQLETQYEREKALRKRAEEE--LEEIEDQWEQETKDLLSQVESLEEENRRLE 109

                          90       100
                  ....*....|....*....|....*
gi 1958669375 497 EENANLQEyvEKETQEKKRLSRTNE 521
Cdd:pfam09744 110 ADHVSRLE--EKEAELKKEYSKLHE 132
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 321-477 6.10e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.85  E-value: 6.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  321 RCQHQEQVEDITASHeaallemennhtvaITILQDDHDH--KVQELMSTHEFEKKELEENFEKLRLSLQDQVDTLTFQSQ 398
Cdd:smart00787 138 RMKLLEGLKEGLDEN--------------LEGLKEDYKLlmKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDP 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  399 SLRDRAQrfeEALRKTtEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKN--------IILEEK 470
Cdd:smart00787 204 TELDRAK---EKLKKL-LQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCrgftfkeiEKLKEQ 279


                   ....*..
gi 1958669375  471 IQVLQQQ 477
Cdd:smart00787 280 LKLLQSL 286
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 183-487 1.69e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 1.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  183 QAREAERQLaQRLRDRCEWQARQLGLARRELKKAIQGFDAMAVSAKHFFGKSERALAKEKELSIELANIRDEVAFNTAKC 262
Cdd:TIGR02168  692 KIAELEKAL-AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  263 EKLQKEKEALERRFEEELRRLgwQQQAEVQELQERLQQQFQAESARLQAEHQDQMLRM-RCQHQ-----EQVEDITASHE 336
Cdd:TIGR02168  771 EEAEEELAEAEAEIEELEAQI--EQLKEELKALREALDELRAELTLLNEEAANLRERLeSLERRiaateRRLEDLEEQIE 848

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  337 AALLEMENNhTVAITILQDDHDHKVQELMStHEFEKKELEENFEKLRLSLQDQVDTLtfqsQSLRDRAQRFEEALRKTTE 416
Cdd:TIGR02168  849 ELSEDIESL-AAEIEELEELIEELESELEA-LLNERASLEEALALLRSELEELSEEL----RELESKRSELRRELEELRE 922

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958669375  417 EQleialapyQHLEEDMQSLKQvlEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQ 487
Cdd:TIGR02168  923 KL--------AQLELRLEGLEV--RIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 185-528 2.89e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 185 REAERQLAQ------RLRDRCEWQARQLG-LAR--------RELKKAIQGFDAmavsakhffgksERALAKEKELSIELA 249
Cdd:COG1196   175 EEAERKLEAteenleRLEDILGELERQLEpLERqaekaeryRELKEELKELEA------------ELLLLKLRELEAELE 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 250 NIRDEVAFNTAKCEKLQKEKEALERRFEEELRrlgwQQQAEVQELQERLQQQFQAESARLQAEHQDQMLRMRCQHQEQVE 329
Cdd:COG1196   243 ELEAELEELEAELEELEAELAELEAELEELRL----ELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 330 DITASHEAALLEMENNHTVAITILQDDHDHKVQELmsthefekKELEENFEKLRLSLQDQVDTLTFQSQSLRDRAQRFEE 409
Cdd:COG1196   319 EELEEELAELEEELEELEEELEELEEELEEAEEEL--------EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 410 ALRKTTEEQLEIalapyQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQNT 489
Cdd:COG1196   391 ALRAAAELAAQL-----EELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELL 465

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1958669375 490 VVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 528
Cdd:COG1196   466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 232-523 4.77e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.67  E-value: 4.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  232 GKSERALAKEKELSIELANIRDEVAFNTAKCEKLQKE-KEALERRFEEELRRLGWQQQAEvqeLQERLQQQFQAESARLQ 310
Cdd:TIGR02168  663 GGSAKTNSSILERRREIEELEEKIEELEEKIAELEKAlAELRKELEELEEELEQLRKELE---ELSRQISALRKDLARLE 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  311 AEHQdQMLRMRCQHQEQVEDITASHEAALLEMEnnhtvaitilqddhdhKVQELMSTHEFEKKELEENFEKlrlsLQDQV 390
Cdd:TIGR02168  740 AEVE-QLEERIAQLSKELTELEAEIEELEERLE----------------EAEEELAEAEAEIEELEAQIEQ----LKEEL 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  391 DTLTFQSQSLRDRAQRFEEALRKTTEEqleialapYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKniiLEEK 470
Cdd:TIGR02168  799 KALREALDELRAELTLLNEEAANLRER--------LESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE---LEEL 867

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958669375  471 IQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 523
Cdd:TIGR02168  868 IEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEEL 920
PHA03247 PHA03247
large tegument protein UL36; Provisional
 13-220 9.72e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 9.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   13 KRASN-SNAAKSGLPKSGLRPPGySRLPAAKLAAFGF----------VRSSSVSAVPSTQSLDSAQQEQ----SRPVTRP 77
Cdd:PHA03247  2665 RRARRlGRAAQASSPPQRPRRRA-ARPTVGSLTSLADpppppptpepAPHALVSATPLPPGPAAARQASpalpAAPAPPA 2743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   78 TFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTSTPAGAKKEPQK--------------DPEAKK 143
Cdd:PHA03247  2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDpadppaavlapaaaLPPAAS 2823

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958669375  144 PAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKPDLQAREAERQLAQRLRDRCEWQARQlgLARRELKKAIQGF 220
Cdd:PHA03247  2824 PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR--LARPAVSRSTESF 2898
PRK11281 PRK11281
mechanosensitive channel MscK;
373-520 5.83e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.06  E-value: 5.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  373 KELEENFEKLRLSLQDQVDTL--------TFQSQSLRDRAQRFE-------------------EALRKTTEEQLEIALA- 424
Cdd:PRK11281   124 RQLESRLAQTLDQLQNAQNDLaeynsqlvSLQTQPERAQAALYAnsqrlqqirnllkggkvggKALRPSQRVLLQAEQAl 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  425 -----PYQHLE----EDMQSLKQV-LEMKNQQIHLQEKKIIELEKLV-EKNIILEEKiQVLQQQNEDLKARIDQNTVVTR 493
Cdd:PRK11281   204 lnaqnDLQRKSlegnTQLQDLLQKqRDYLTARIQRLEHQLQLLQEAInSKRLTLSEK-TVQEAQSQDEAARIQANPLVAQ 282

                          170       180
                   ....*....|....*....|....*..
gi 1958669375  494 QLsEENANLQEYVEKETQEKKRLSRTN 520
Cdd:PRK11281   283 EL-EINLQLSQRLLKATEKLNTLTQQN 308
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 20-210 8.47e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 8.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   20 AAKSGLPKSGLRPPGYSRLPA-AKLAAFGFVRSSSVSAVPSTQSLDSAQQEQsRPVTRPTfgseeQVSLKQAVPSKDTPK 98
Cdd:PHA03307   203 SPRPPRRSSPISASASSPAPApGRSAADDAGASSSDSSSSESSGCGWGPENE-CPLPRPA-----PITLPTRIWEASGWN 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   99 GAGRAAPASSSNATPPRRSLLPAPKS-------TSTPAGAKKEPQKDPEAKKPAVSSPKRTASATT------KLHSPGYP 165
Cdd:PHA03307   277 GPSSRPGPASSSSSPRERSPSPSPSSpgsgpapSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSpgpspsRSPSPSRP 356

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1958669375  166 KQRTTAPRNEVPPKPDLQAREAERQLAQRLRDRCEWQARQLGLAR 210
Cdd:PHA03307   357 PPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRR 401
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 371-523 2.81e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 371 EKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRAQRFEEaLRKTTEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQ 450
Cdd:TIGR04523 367 EKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEK-LNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDL 445

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958669375 451 EKKIIELEKLVEKniiLEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 523
Cdd:TIGR04523 446 TNQDSVKELIIKN---LDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDL 515
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
13-173 2.96e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  13 KRASNSNAAKSGLPKSGLRPPGYSRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSRPVTRPTFGSEEQVSLKQAVP 92
Cdd:PRK07003  386 RAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDE 465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  93 SKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGyPKQRTTAP 172
Cdd:PRK07003  466 RDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPT-PAAAAPAA 544


                  .
gi 1958669375 173 R 173
Cdd:PRK07003  545 R 545
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 181-483 3.15e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 181 DLQAREAERQLAQRLRDRCEWQARQLGLARRELKKAIQGFDAmavsakhffgKSERALAKEKELSIELANIRDEVAFNTA 260
Cdd:COG1196   240 ELEELEAELEELEAELEELEAELAELEAELEELRLELEELEL----------ELEEAQAEEYELLAELARLEQDIARLEE 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 261 KCEKLQKEKEalerrfeeelrrlgwqQQAEVQELQERLQQQFQAESARLQAEHQDQmlrmrcqhQEQVEDITASHEAALL 340
Cdd:COG1196   310 RRRELEERLE----------------ELEEELAELEEELEELEEELEELEEELEEA--------EEELEEAEAELAEAEE 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 341 EMENNHTVAITILQDDHDHKVQELMSTHE-FEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRAQRFEEALRKTTEEQL 419
Cdd:COG1196   366 ALLEAEAELAEAEEELEELAEELLEALRAaAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958669375 420 EIALAPYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQQQNEDLKA 483
Cdd:COG1196   446 EAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 50-180 3.52e-04

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 43.23  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  50 RSSSVSAVP-----STQSLDSAQQEQS----RPVTRPTFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLP 120
Cdd:pfam13254 196 RPNSFKEVTpvglmRSPAPGGHSKSPSvsgiSADSSPTKEEPSEEADTLSTDKEQSPAPTSASEPPPKTKELPKDSEEPA 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 121 APkstSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKP 180
Cdd:pfam13254 276 AP---SKSAEASTEKKEPDTESSPETSSEKSAPSLLSPVSKASIDKPLSSPDRDPLSPKP 332
motB PRK12799
flagellar motor protein MotB; Reviewed
 52-184 5.56e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 42.40  E-value: 5.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  52 SSVSAVPSTQSLDSAQQEQSRPVTRPTFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTSTPAGA 131
Cdd:PRK12799  279 NRALDIEKATGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDV 358

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958669375 132 KKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKPDLQA 184
Cdd:PRK12799  359 TLPGTVALPAAEPVNMQPQPMSTTETQQSSTGNITSTANGPTTSLPAAPASNI 411
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 181-487 6.52e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 6.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  181 DLQAREAERQLAQRLRDRCEWQARQLGLARRELKKAIQGFDAMAVSAKHFFGKSERALAKEKElsiELANIRDEVAFNTA 260
Cdd:TIGR02169  696 ELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKS---ELKELEARIEELEE 772

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  261 KCEKLQKEKEALERRFEEELRRLGWQQQAEVQELQERLQQQFQAESARLQAEHQD-QMLRMRCQH-QEQVEDITASHEAA 338
Cdd:TIGR02169  773 DLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkEYLEKEIQElQEQRIDLKEQIKSI 852

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  339 LLEMENNHTVAITILQ--DDHDHKVQELMSTHEFEKKELEENFEKLRlSLQDQVDTLTFQSQSLRDRAQRFEEALRKTTE 416
Cdd:TIGR02169  853 EKEIENLNGKKEELEEelEELEAALRDLESRLGDLKKERDELEAQLR-ELERKIEELEAQIEKKRKRLSELKAKLEALEE 931

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  417 EQLEIALAPYQHLEE-----DMQSLKQVLEMKNQQIHLQE----KKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQ 487
Cdd:TIGR02169  932 ELSEIEDPKGEDEEIpeeelSLEDVQAELQRVEEEIRALEpvnmLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEE 1011
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 95-189 7.12e-04

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 42.25  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  95 DTPKGAGRAAPASS-SNATPPRRSLLPAPKSTSTPAGAKKEPqkdPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPr 173
Cdd:PHA03291  189 ALPLSAPRLGPADVfVPATPRPTPRTTASPETTPTPSTTTSP---PSTTIPAPSTTIAAPQAGTTPEAEGTPAPPTPGG- 264

                          90
                  ....*....|....*.
gi 1958669375 174 NEVPPKPDLQAREAER 189
Cdd:PHA03291  265 GEAPPANATPAPEASR 280
Jnk-SapK_ap_N pfam09744
JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...
 417-521 7.46e-04

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.


Pssm-ID: 462875 [Multi-domain]  Cd Length: 150  Bit Score: 40.29  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 417 EQLEIALAPYQHLEEDMQSLKQvlemKNQQIHLQEKKIIELEKLVEKNiiLEEKIQVLQQQNEDLKARIDQNTVVTRQLS 496
Cdd:pfam09744  36 ELLESLASRNQEHNVELEELRE----DNEQLETQYEREKALRKRAEEE--LEEIEDQWEQETKDLLSQVESLEEENRRLE 109

                          90       100
                  ....*....|....*....|....*
gi 1958669375 497 EENANLQEyvEKETQEKKRLSRTNE 521
Cdd:pfam09744 110 ADHVSRLE--EKEAELKKEYSKLHE 132
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
374-534 7.74e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 7.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  374 ELEENFEKLR------LSLQDQVDTLtfqsQSLRDRAQRFEEALRKTTEEQLEIALAPYQHLEEDMQSLKQVLEmknqqi 447
Cdd:COG4913    229 ALVEHFDDLErahealEDAREQIELL----EPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELE------ 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  448 HLQEkkiiELEKLVEKNIILEEKIQVLQQQNEDLKARIDQNTVVTR-QLSEENANLqeyvEKETQEKKRLSRTNEELLWK 526
Cdd:COG4913    299 ELRA----ELARLEAELERLEARLDALREELDELEAQIRGNGGDRLeQLEREIERL----ERELEERERRRARLEALLAA 370


                   ....*...
gi 1958669375  527 LQTGDPTS 534
Cdd:COG4913    371 LGLPLPAS 378
PHA03381 PHA03381
tegument protein VP22; Provisional
 64-178 8.47e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 41.53  E-value: 8.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  64 DSAQQEQSRPVTRPTFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSllPAPKSTSTPAGAKK-EPQKDPEAK 142
Cdd:PHA03381   76 GSSSEDERPADPRPSRRPHAQPEASGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRGRKSaCADSAALLD 153

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958669375 143 KPAVSSPKRT---ASATTKLHSpgypkqrTTAPRNEVPP 178
Cdd:PHA03381  154 APAPAAPKRQktpAGLARKLHF-------STAPTSPTAP 185
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 360-524 8.58e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 8.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  360 KVQELMSTHEFEKKELEENFEKLRL---SLQDQVDTLTFQSQSLRDRAQRFEEALrktteeqleialapyQHLEEDMQSL 436
Cdd:TIGR02168  250 EAEEELEELTAELQELEEKLEELRLevsELEEEIEELQKELYALANEISRLEQQK---------------QILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  437 KQVLEMKNQQIHLQEKKIIELEKLVEKniiLEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEyvEKETQEKKRL 516
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAE---LEEKLEELKEELESLEAELEELEAELEELESRLEELEE--QLETLRSKVA 389


                   ....*...
gi 1958669375  517 SRTNEELL 524
Cdd:TIGR02168  390 QLELQIAS 397
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 29-204 1.20e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  29 GLRPPGYSRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSRPVTRPtfgseeqvslkqaVPSKDTPKGAGRAAPASS 108
Cdd:PRK14951  345 GLAPDEYAALTMVLLRLLAFKPAAAAEAAAPAEKKTPARPEAAAPAAAP-------------VAQAAAAPAPAAAPAAAA 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 109 SNATPPRRSLLPAPKS-----------TSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVP 177
Cdd:PRK14951  412 SAPAAPPAAAPPAPVAapaaaapaaapAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958669375 178 PKPD--------LQAREAERQLAQRL--------RDRCEWQAR 204
Cdd:PRK14951  492 EEGDvwhatvqqLAAAEAITALARELalqselvaRDGDQWLLR 534
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-161 1.46e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   31 RPPgySRLPAAKLAAFGFVRSSSVSA---VPSTQSLDSAQQEQSRP-----VTRPTFGSEEQVSLKQAVPSKDTPKGAGR 102
Cdd:PHA03247  2865 RPP--SRSPAAKPAAPARPPVRRLARpavSRSTESFALPPDQPERPpqpqaPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958669375  103 AAPASSSNATPPRRSLLPAPKSTSTPAGA-----KKEPQKDPEAKKPAVSSPKRTASATTKLHS 161
Cdd:PHA03247  2943 LAPTTDPAGAGEPSGAVPQPWLGALVPGRvavprFRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
31-203 1.47e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  31 RPPGYSRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSR-----------PVTRPTFGSEEQVSLKQAVPSKDTPKG 99
Cdd:PRK12323  401 APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARgpggapapapaPAAAPAAAARPAAAGPRPVAAAAAAAP 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 100 AGR---AAPASSSNATPPRRSLLPAPKSTS------TPAGAKKEPQKDPEAKKPavsSPKRTASATTKLHSPGYPKQRTT 170
Cdd:PRK12323  481 ARAapaAAPAPADDDPPPWEELPPEFASPApaqpdaAPAGWVAESIPDPATADP---DDAFETLAPAPAAAPAPRAAAAT 557

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958669375 171 APR-NEVPPK--------------PDLQAREAERQLAQRLRDRCEWQA 203
Cdd:PRK12323  558 EPVvAPRPPRasasglpdmfdgdwPALAARLPVRGLAQQLARQSELAG 605
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 371-523 1.74e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  371 EKKELEENFEKLRL-SLQDQVDTLTFQSQSLRDRAQRFEEALRKTTE--EQLEIALAP----YQHLEEDMQSLKQVLEMK 443
Cdd:TIGR02168  221 ELRELELALLVLRLeELREELEELQEELKEAEEELEELTAELQELEEklEELRLEVSEleeeIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  444 NQQI-HLQEKkiieLEKLVEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 522
Cdd:TIGR02168  301 EQQKqILRER----LANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE 376


                   .
gi 1958669375  523 L 523
Cdd:TIGR02168  377 L 377
PHA03247 PHA03247
large tegument protein UL36; Provisional
 23-184 1.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   23 SGLPKSGLRPPGYSRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSRPVTRPTFGSEEQVSLKQAVPSKDTPKGAG- 101
Cdd:PHA03247  2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSv 2856

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  102 -------RAAPASSSNATP-----PRRSLLPAPKSTSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRT 169
Cdd:PHA03247  2857 apggdvrRRPPSRSPAAKPaaparPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          170
                   ....*....|....*
gi 1958669375  170 TAPRNEVPPKPDLQA 184
Cdd:PHA03247  2937 PRPQPPLAPTTDPAG 2951
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 302-523 1.88e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  302 FQAESARLQAEhQDQMLRMRCQHQEQVEDITAS---HEAALLEMENNHTVA------ITILQDDHDHKVQELMSTHEFEK 372
Cdd:TIGR02168  237 LREELEELQEE-LKEAEEELEELTAELQELEEKleeLRLEVSELEEEIEELqkelyaLANEISRLEQQKQILRERLANLE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  373 KELE------ENFEKLRLSLQDQVDTLTFQSQSLRDRAQRFEEALrKTTEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQ 446
Cdd:TIGR02168  316 RQLEeleaqlEELESKLDELAEELAELEEKLEELKEELESLEAEL-EELEAELEELESRLEELEEQLETLRSKVAQLELQ 394

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958669375  447 IHLQEKKIIELEKLVEkniILEEKIQVLQQQNEDLKARIDQNTV--VTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 523
Cdd:TIGR02168  395 IASLNNEIERLEARLE---RLEDRRERLQQEIEELLKKLEEAELkeLQAELEELEEELEELQEELERLEEALEELREEL 470
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 368-528 3.12e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 3.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  368 HEFEKK--ELEENFEKL---RLSLQDQVDTLTFQSQslrdRAQRFEEALRKTTEEQLEIALAPYQHLEEDMQSLKQVLEM 442
Cdd:TIGR02168  175 KETERKleRTRENLDRLediLNELERQLKSLERQAE----KAERYKELKAELRELELALLVLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  443 KNQQIHLQEKKIIELE-KLVEKNII---LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSR 518
Cdd:TIGR02168  251 AEEELEELTAELQELEeKLEELRLEvseLEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330

                          170
                   ....*....|
gi 1958669375  519 TNEELLWKLQ 528
Cdd:TIGR02168  331 KLDELAEELA 340
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 13-198 3.27e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   13 KRASNSNAAKSGLPKSG--------LRPPGYSRLPAAKLAAfgfVRSSSVSAVPSTQSLDSAQQEQSRPVTRPTFGSEEQ 84
Cdd:PHA03307   232 AGASSSDSSSSESSGCGwgpenecpLPRPAPITLPTRIWEA---SGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPA 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   85 VSLKQAVPSKDTPKGAGRAAPASSSnatPPRRSLLPAPKSTSTPAGAkkePQKDPEAkkPAVSSPKRTASAttklhSPGY 164
Cdd:PHA03307   309 PSSPRASSSSSSSRESSSSSTSSSS---ESSRGAAVSPGPSPSRSPS---PSRPPPP--ADPSSPRKRPRP-----SRAP 375

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1958669375  165 PKQRTTAPRNEVppkpdlqaREAERQLAQRLRDR 198
Cdd:PHA03307   376 SSPAASAGRPTR--------RRARAAVAGRARRR 401
PHA03247 PHA03247
large tegument protein UL36; Provisional
 24-150 3.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   24 GLPKSglRPPGYSrlPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSrPVTRPTFGSEEQVSLKQAVPSKDTPKGAGRA 103
Cdd:PHA03247   350 GFPKR--RRPTWT--PPSSLEDLSAGRHHPKRASLPTRKRRSARHAAT-PFARGPGGDDQTRPAAPVPASVPTPAPTPVP 424

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958669375  104 APASSSNATPPRRSLLPAPKS-TSTPAGAKKEPQKDPEAKKPAVSSPK 150
Cdd:PHA03247   425 ASAPPPPATPLPSAEPGSDDGpAPPPERQPPAPATEPAPDDPDDATRK 472
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 187-524 4.31e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 4.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  187 AERQLAQRLRDRCEWQARQLGLARRELKKAIQGFDAMAVSAKHFFGKSERALAKEKELSIELANIRDEVAFNTAKCEKLQ 266
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE 750

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  267 KEKEALERRFeeelrrlgwQQQAEVQELQERLQQQFQAESARLQAEHQDQMLRMRCQHQEQVEDITASHEAALLEME--- 343
Cdd:TIGR02169  751 QEIENVKSEL---------KELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEqkl 821

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  344 NNHTVAITILQDDHDHKVQELMSTHEfEKKELEENFEKLRLSL----------QDQVDTLTFQSQSLRDRAQRFEEALRK 413
Cdd:TIGR02169  822 NRLTLEKEYLEKEIQELQEQRIDLKE-QIKSIEKEIENLNGKKeeleeeleelEAALRDLESRLGDLKKERDELEAQLRE 900

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  414 TTEEQLEIALApYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQNTVVTR 493
Cdd:TIGR02169  901 LERKIEELEAQ-IEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQ 979

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1958669375  494 QLSEENANLQEYVEKetqeKKRLSRTNEELL 524
Cdd:TIGR02169  980 EYEEVLKRLDELKEK----RAKLEEERKAIL 1006
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
96-187 5.00e-03

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 39.40  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  96 TPKGAGRAAPASSSNATPPRrsllPAPKSTS----TPAGAKKEPQKdpEAKKPAVSSPKRTASATTKLHSPGYPKQRTTA 171
Cdd:PRK12373  231 LAPWQGDAAPVPPSEAARPK----SADAETNaalkTPATAPKAAAK--NAKAPEAQPVSGTAAAEPAPKEAAKAAAAAAK 304

                          90
                  ....*....|....*.
gi 1958669375 172 PRNEVPPKPDLQAREA 187
Cdd:PRK12373  305 PALEDKPRPLGIARPG 320
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 321-477 6.10e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.85  E-value: 6.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  321 RCQHQEQVEDITASHeaallemennhtvaITILQDDHDH--KVQELMSTHEFEKKELEENFEKLRLSLQDQVDTLTFQSQ 398
Cdd:smart00787 138 RMKLLEGLKEGLDEN--------------LEGLKEDYKLlmKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDP 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  399 SLRDRAQrfeEALRKTtEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKN--------IILEEK 470
Cdd:smart00787 204 TELDRAK---EKLKKL-LQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCrgftfkeiEKLKEQ 279


                   ....*..
gi 1958669375  471 IQVLQQQ 477
Cdd:smart00787 280 LKLLQSL 286
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 40-178 6.56e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 39.16  E-value: 6.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  40 AAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSRPVTRPTFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLL 119
Cdd:PTZ00436  204 AAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAA 283

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958669375 120 PAPKSTSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPgyPKQRTTAPRNEVPP 178
Cdd:PTZ00436  284 PPAKAAAPPAKAAAAPAKAAAAPAKAAAAPAKAAAPPAKAAAP--PAKAATPPAKAAAP 340
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 362-529 6.60e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.67  E-value: 6.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  362 QELMSTHEFEKKELEENFEKLRlSLQDQVDTLTFQSQSLRDRAQRFEEALRKtteEQLEIAlAPYQHL-EEDMQSLKQVL 440
Cdd:TIGR02169  726 EQLEQEEEKLKERLEELEEDLS-SLEQEIENVKSELKELEARIEELEEDLHK---LEEALN-DLEARLsHSRIPEIQAEL 800

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  441 EMKNQQIHLQEKKIIELE----KLVEKNIILEEKIQVLQQQNEDLKARIDQN---------------------TVVTRQL 495
Cdd:TIGR02169  801 SKLEEEVSRIEARLREIEqklnRLTLEKEYLEKEIQELQEQRIDLKEQIKSIekeienlngkkeeleeeleelEAALRDL 880

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1958669375  496 SEENANLQEYVEKETQEKKRLSRTNEELLWKLQT 529
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEK 914
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 13-188 7.12e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.38  E-value: 7.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   13 KRASNSNAAKSGLPKSGLRPPgysRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSRPVTRPTFGSEEQVSLKQAVP 92
Cdd:PHA03307   746 ARASAWDITDALFSNPSLVPA---KLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSR 822

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375   93 SKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTK-LHSPGYPKQRTTA 171
Cdd:PHA03307   823 SHTPDGGSESSGPARPPGAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPpKAAAAAPPAGAPA 902

                          170
                   ....*....|....*..
gi 1958669375  172 PRNEVPPKPDLQAREAE 188
Cdd:PHA03307   903 PRPRPAPRVKLGPMPPG 919
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 363-529 7.28e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.23  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 363 ELMSTHEFE----KKELEENFEKLR------LSLQDQVDTLTFQSQSLRDRAQRFEEALRKTTEEQLEI--ALAPYQHLE 430
Cdd:TIGR04523 117 EQKNKLEVElnklEKQKKENKKNIDkflteiKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIqkNIDKIKNKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 431 EDMQSLKQVLEMKNQQIHLQEKKIIELEKlveKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKET 510
Cdd:TIGR04523 197 LKLELLLSNLKKKIQKNKSLESQISELKK---QNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                         170
                  ....*....|....*....
gi 1958669375 511 QEKKRLSRTNEELLWKLQT 529
Cdd:TIGR04523 274 KELEQNNKKIKELEKQLNQ 292
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
20-189 7.43e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.45  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  20 AAKSGLPKSGLRPPGYSRLPAAKLAAfGFVRSSSVSAVPSTQSLDSAQQEQSRPVTRPTFGSEEQVSLKQAVPSKDTPKG 99
Cdd:PRK07003  375 RVAGAVPAPGARAAAAVGASAVPAVT-AVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKA 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 100 AGRAAPASSSNATPPRRSLLPAPKST---STPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPRNEV 176
Cdd:PRK07003  454 NARASADSRCDERDAQPPADSGSASApasDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEAR 533

                         170
                  ....*....|...
gi 1958669375 177 PPKPDlQAREAER 189
Cdd:PRK07003  534 PPTPA-AAAPAAR 545
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 371-523 7.77e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.28  E-value: 7.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  371 EKKELE---ENFEKLRLSLQDQVDTLTFQSQSLRDRAQRFEEALRKTTEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQI 447
Cdd:TIGR02169  231 EKEALErqkEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSI 310

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958669375  448 HLQEKkiiELEKLVEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 523
Cdd:TIGR02169  311 AEKER---ELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAET 383
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
371-487 8.27e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.98  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 371 EKKELEENFEKLRL---SLQDQVDTLTFQSQsLRDRAQRFEEALRKTTE-----EQLEIALAPYQHLEEDMQSLKQVLEM 442
Cdd:COG4717    96 ELEELEEELEELEAeleELREELEKLEKLLQ-LLPLYQELEALEAELAElperlEELEERLEELRELEEELEELEAELAE 174

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958669375 443 KNQQIHLQEKK------------IIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQ 487
Cdd:COG4717   175 LQEELEELLEQlslateeelqdlAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231
PHA03378 PHA03378
EBNA-3B; Provisional
 31-184 8.39e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 39.28  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375  31 RPPGYSRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSRPV-TRPTFGSEEQVSLKQAVPSKDTPKGA--GRAAPAS 107
Cdd:PHA03378  699 RAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGrARPPAAAPGRARPPAAAPGRARPPAAapGAPTPQP 778

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 108 SSNATP-----PRRSLLPAPKSTSTPAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKPDL 182
Cdd:PHA03378  779 PPQAPPapqqrPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSP 858


                  ..
gi 1958669375 183 QA 184
Cdd:PHA03378  859 GS 860
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 429-523 8.64e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 8.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 429 LEEDMQSLKQV---LEMKNQQIHLQ-EKKIIELEKLVEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQE 504
Cdd:TIGR04523 340 LNEQISQLKKEltnSESENSEKQRElEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ 419

                          90
                  ....*....|....*....
gi 1958669375 505 YVEKETQEKKRLSRTNEEL 523
Cdd:TIGR04523 420 EKELLEKEIERLKETIIKN 438
PRK12704 PRK12704
phosphodiesterase; Provisional
 398-522 8.66e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 38.99  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669375 398 QSLRDRAQRFEEALRKTTEEQLEIALapyQHLEEDMQSLKQVLEmknQQIHLQEKKIIELEK-LVEKNIILEEKIQVLQQ 476
Cdd:PRK12704   34 KEAEEEAKRILEEAKKEAEAIKKEAL---LEAKEEIHKLRNEFE---KELRERRNELQKLEKrLLQKEENLDRKLELLEK 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958669375 477 QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSR-TNEE 522
Cdd:PRK12704  108 REEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGlTAEE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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