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Conserved domains on  [gi|1958669619|ref|XP_038945701|]
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N-lysine methyltransferase KMT5A isoform X5 [Rattus norvegicus]

Protein Classification

SET domain-containing protein( domain architecture ID 14410543)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones; similar to vertebrate N-lysine methyltransferase KMT5A that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 192-331 1.02e-88

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


:

Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 262.51  E-value: 1.02e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 192 SEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLS 271
Cdd:cd10528     1 KEKKKEIEELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958669619 272 KTYCVDATQETNRLGRLINHSKC-GNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd10528    81 KTYCVDATKESGRLGRLINHSKKkPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDYGDR 141
 
Name Accession Description Interval E-value
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 192-331 1.02e-88

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 262.51  E-value: 1.02e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 192 SEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLS 271
Cdd:cd10528     1 KEKKKEIEELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958669619 272 KTYCVDATQETNRLGRLINHSKC-GNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd10528    81 KTYCVDATKESGRLGRLINHSKKkPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDYGDR 141
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 216-333 3.03e-28

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 106.26  E-value: 3.03e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619  216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYfqyLSKTYCVDATQETNrLGRLINHSKCG 295
Cdd:smart00317   9 PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFD---IDSDLCIDARRKGN-LARFINHSCEP 84

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958669619  296 NCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSK 333
Cdd:smart00317  85 NCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 219-329 1.81e-27

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 104.14  E-value: 1.81e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHG-DLIEITDAKKREALYAQDPSTGCYMYYFQYLSK--TYCVDAT-QETNRLGRLINHSKC 294
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEvLLITKEEADKRELLYYDKLELRLWGPYLFTLDEdsEYCIDARaLYYGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958669619 295 GNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYG 329
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
216-330 2.13e-20

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 85.78  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREalyaqDPSTGCYMYYFQYLSKTYcVDATQETNrLGRLINHSKCG 295
Cdd:COG2940    14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERRE-----PHKEPLHTYLFELDDDGV-IDGALGGN-PARFINHSCDP 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958669619 296 NCQTKLHDidgvPHLILIASRDIAAGEELLYDYGD 330
Cdd:COG2940    87 NCEADEED----GRIFIVALRDIAAGEELTYDYGL 117
 
Name Accession Description Interval E-value
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 192-331 1.02e-88

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 262.51  E-value: 1.02e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 192 SEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLS 271
Cdd:cd10528     1 KEKKKEIEELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958669619 272 KTYCVDATQETNRLGRLINHSKC-GNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd10528    81 KTYCVDATKESGRLGRLINHSKKkPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDYGDR 141
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 219-328 6.79e-30

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 111.53  E-value: 6.79e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHGDLI--EITDakKREALYAQDPSTGCYMYYfqyLSKTYCVDATQETNRlGRLINHSKCGN 296
Cdd:cd10518    25 GWGLFAKRPIAAGEMVIEYVGEVIrpIVAD--KREKRYDEEGGGGTYMFR---IDEDLVIDATKKGNI-ARFINHSCDPN 98

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958669619 297 CQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd10518    99 CYAKIITVDGEKHIVIFAKRDIAPGEELTYDY 130
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 216-333 3.03e-28

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 106.26  E-value: 3.03e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619  216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYfqyLSKTYCVDATQETNrLGRLINHSKCG 295
Cdd:smart00317   9 PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFD---IDSDLCIDARRKGN-LARFINHSCEP 84

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958669619  296 NCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSK 333
Cdd:smart00317  85 NCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 219-329 1.81e-27

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 104.14  E-value: 1.81e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHG-DLIEITDAKKREALYAQDPSTGCYMYYFQYLSK--TYCVDAT-QETNRLGRLINHSKC 294
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEvLLITKEEADKRELLYYDKLELRLWGPYLFTLDEdsEYCIDARaLYYGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958669619 295 GNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYG 329
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 210-330 5.65e-23

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 92.70  E-value: 5.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 210 MKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGcymYYFQYLSKTYCVDATQETNrLGRLI 289
Cdd:cd10531     2 LELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSN---FYILSLSDDVVIDATRKGN-LSRFI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958669619 290 NHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGD 330
Cdd:cd10531    78 NHSCEPNCETQKWIVNGEYRIGIFALRDIPAGEELTFDYNF 118
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 219-328 9.96e-23

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 92.45  E-value: 9.96e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaQDPSTGCYMYYfqyLSKTYCVDATQETNRlGRLINHSKCGNCQ 298
Cdd:cd19170    25 GRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYY-ESKGIGCYMFR---IDDDEVVDATMHGNA-ARFINHSCEPNCY 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958669619 299 TKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19170   100 SRVVNIDGKKHIVIFALRRILRGEELTYDY 129
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 219-330 4.32e-21

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 86.91  E-value: 4.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTgcymYYFQyLSKTYCVDATQETNRLgRLINHSKCGNCQ 298
Cdd:cd10519    12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSS----YLFN-LNDQFVVDATRKGNKI-RFANHSSNPNCY 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958669619 299 TKLHDIDGVPHLILIASRDIAAGEELLYDYGD 330
Cdd:cd10519    86 AKVMMVNGDHRIGIFAKRDIEAGEELFFDYGY 117
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
216-330 2.13e-20

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 85.78  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREalyaqDPSTGCYMYYFQYLSKTYcVDATQETNrLGRLINHSKCG 295
Cdd:COG2940    14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERRE-----PHKEPLHTYLFELDDDGV-IDGALGGN-PARFINHSCDP 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958669619 296 NCQTKLHDidgvPHLILIASRDIAAGEELLYDYGD 330
Cdd:COG2940    87 NCEADEED----GRIFIVALRDIAAGEELTYDYGL 117
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 218-328 2.47e-19

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 83.25  E-value: 2.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 218 KGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaQDPSTGCYMYYfqyLSKTYCVDATqETNRLGRLINHSKCGNC 297
Cdd:cd19171    24 QGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIY-ESQNRGIYMFR---IDNDWVIDAT-MTGGPARYINHSCNPNC 98

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958669619 298 QTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19171    99 VAEVVTFDKEKKIIIISNRRIAKGEELTYDY 129
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 218-328 2.70e-18

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 80.32  E-value: 2.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 218 KGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDpstGCYMYYFQYLSKTYCVDATQETNrLGRLINHSKCGNC 297
Cdd:cd19172    12 KGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYARE---GNRHYYFMALKSDEIIDATKKGN-LSRFINHSCEPNC 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958669619 298 QTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19172    88 ETQKWTVNGELRVGFFAKRDIPAGEELTFDY 118
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 219-328 2.41e-17

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 78.14  E-value: 2.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaQDPSTGCYMYYfqyLSKTYCVDATQETNRlGRLINHSKCGNCQ 298
Cdd:cd19206    25 GRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYY-DSKGIGCYMFR---IDDSEVVDATMHGNA-ARFINHSCEPNCY 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958669619 299 TKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19206   100 SRVINIDGQKHIVIFAMRKIYRGEELTYDY 129
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 217-329 3.23e-17

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 79.34  E-value: 3.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 217 GKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaqDPSTGCY---MYYFQYLSKT---YCVDATQETNrLGRLIN 290
Cdd:cd10538    98 KKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIY--DKSGGSYlfdLDEFSDSDGDgeeLCVDATFCGN-VSRFIN 174

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958669619 291 HSKCGNCQTKLHDIDG----VPHLILIASRDIAAGEELLYDYG 329
Cdd:cd10538   175 HSCDPNLFPFNVVIDHddlrYPRIALFATRDILPGEELTFDYG 217
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 211-331 4.37e-17

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 76.23  E-value: 4.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 211 KIDLIDGKGRGVIATKRFSRGDFVVEYHGdliEITDAKKREA--LYAQDPStgcYMYYFQYLSktYCVDATQETNrLGRL 288
Cdd:cd10522     6 MIPNLSHNGLGLFAAETIAKGEFVGEYTG---EVLDRWEEDRdsVYHYDPL---YPFDLNGDI--LVIDAGKKGN-LTRF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958669619 289 INHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd10522    77 INHSDQPNLELIVRTLKGEQHIGFVAIRDIKPGEELFISYGPK 119
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 201-338 5.21e-17

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 79.26  E-value: 5.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 201 LIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKReaLYAQDPSTGCYMYYFQ-YLS-----KTY 274
Cdd:cd10544    83 VVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRR--TKSQTKGDMNYIIVLReHLSsgkvlETF 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958669619 275 cVDATQETNrLGRLINHSkcgnCQTKLH----DIDG-VPHLILIASRDIAAGEELLYDYGDRSKASIEA 338
Cdd:cd10544   161 -VDPTYIGN-IGRFLNHS----CEPNLFmvpvRVDSmVPKLALFAARDIVAGEELSFDYSGEFSNSVES 223
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 211-328 2.90e-16

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 74.38  E-value: 2.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 211 KIDLIDGK--GRGVIATKRFSRGDFVVEYHGDLIEitDAKKREALYAQDpSTGCYMYYFQYLSKTYCVDATQETNrLGRL 288
Cdd:cd19175     1 KMKLVKTEkcGWGLVADEDINAGEFIIEYVGEVID--DKTCEERLWDMK-HKGEKNFYMCEIDKDMVIDATFKGN-LSRF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958669619 289 INHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19175    77 INHSCDPNCELQKWQVDGETRIGVFAIRDIKKGEELTYDY 116
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 216-328 5.81e-16

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 73.87  E-value: 5.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKR-EALYAQDPStgcymYYFQYLSKTYCVDATQETNrLGRLINHSKC 294
Cdd:cd19174     8 EDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRmIEQYHNHSH-----HYCLNLDSGMVIDGYRMGN-EARFVNHSCD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958669619 295 GNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19174    82 PNCEMQKWSVNGVYRIGLFALKDIPAGEELTYDY 115
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 219-331 1.92e-15

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 71.84  E-value: 1.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaqdpstGCYMYYFQY-LSKTYCVDATQETNrLGRLINH----SK 293
Cdd:cd19168    13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRR------GDVSYLYLFeEQEGIWVDAAIYGN-LSRYINHatdkVK 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958669619 294 CGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd19168    86 TGNCMPKIMYVNHEWRIKFTAIKDIKIGEELFFNYGDN 123
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 215-329 3.76e-15

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 69.20  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 215 IDGKGRGVIATKRFSRGDFVVeyhgdlieitdakkrealyaqdpstgcymyyfqylsktycvdatqetnrLGRLINHSKC 294
Cdd:cd08161     7 IPGAGFGLFATRDIPKGEVIG-------------------------------------------------LARFINHSCE 37

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958669619 295 GNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYG 329
Cdd:cd08161    38 PNCEFEEVYVGGKPRVFIVALRDIKAGEELTVDYG 72
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 216-328 1.95e-14

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 69.65  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREAlYAQDpsTGCYMYYFQYLSKTYCVDATQETNrLGRLINHSKCG 295
Cdd:cd19173    10 GDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLK-KAHE--NNITNFYMLTLDKDRIIDAGPKGN-LSRFMNHSCQP 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958669619 296 NCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19173    86 NCETQKWTVNGDTRVGLFAVRDIPAGEELTFNY 118
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 210-331 5.97e-14

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 70.45  E-value: 5.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 210 MKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREalyaqDPStgcymYYFQYLSK---TYCVDATQETNrLG 286
Cdd:cd10543    93 LQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSRE-----DDS-----YLFDLDNKdgeTYCIDARRYGN-IS 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958669619 287 RLINHSkcgnCQTKL--------HDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd10543   162 RFINHL----CEPNLipvrvfveHQDLRFPRIAFFASRDIKAGEELGFDYGEK 210
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 209-328 6.88e-14

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 67.25  E-value: 6.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 209 GMKIDLI----DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQdpstgcYMYYFQY-LSKTYCVDATQETN 283
Cdd:cd19218     1 GSKKHLLlapsDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK------YMCSFLFnLNNDFVVDATRKGN 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958669619 284 RLgRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19218    75 KI-RFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY 118
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 221-328 8.82e-14

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 67.83  E-value: 8.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 221 GVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDpstGCYMYYFQYLSKTYCVDATQETNrLGRLINHSKCGNCQTK 300
Cdd:cd20072    26 GLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQ---GIGSSYLFRIDDDTVVDATKKGN-IARFINHCCDPNCTAK 101

                          90       100
                  ....*....|....*....|....*...
gi 1958669619 301 LHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd20072   102 IIKVEGEKRIVIYAKRDIAAGEELTYDY 129
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 221-328 1.73e-13

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 66.98  E-value: 1.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 221 GVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYfqyLSKTYCVDATQETNrLGRLINHSKCGNCQTK 300
Cdd:cd19169    26 GLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFR---VDDDTIIDATKCGN-LARFINHSCNPNCYAK 101

                          90       100
                  ....*....|....*....|....*...
gi 1958669619 301 LHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19169   102 IITVESQKKIVIYSKRPIAVNEEITYDY 129
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 211-328 5.64e-13

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 65.40  E-value: 5.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 211 KIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYfqyLSKTYCVDATQETNrLGRLIN 290
Cdd:cd19211     5 KIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLT---IDKDRIIDAGPKGN-YSRFMN 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958669619 291 HSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19211    81 HSCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNY 118
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 219-328 5.89e-13

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 65.82  E-value: 5.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 219 GRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaQDPSTGCYMYYFQYLSktyCVDATQETNRlGRLINHSKCGNCQ 298
Cdd:cd19207    25 GRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFY-DSKGIGCYMFRIDDFD---VVDATMHGNA-ARFINHSCEPNCY 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958669619 299 TKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19207   100 SRVIHVEGQKHIVIFALRKIYRGEELTYDY 129
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 216-328 8.08e-13

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 67.32  E-value: 8.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTgcYMY---YFQYLSKtYCVDATQETNrLGRLINHS 292
Cdd:cd10542    96 NGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRT--YLFdldYNDDDCE-YTVDAAYYGN-ISHFINHS 171

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958669619 293 kC----------GNCqtklHDIDgVPHLILIASRDIAAGEELLYDY 328
Cdd:cd10542   172 -CdpnlavyavwINH----LDPR-LPRIAFFAKRDIKAGEELTFDY 211
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 207-328 2.48e-12

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 66.07  E-value: 2.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 207 EEGMKIDLI-----DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTgcYMYYFQYLSKTYCVDATQE 281
Cdd:cd10525    81 QKGIQYDLCifrtdNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGAT--YLFDLDYVEDVYTVDAAYY 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958669619 282 TNrLGRLINHSKCGNCQTKLHDIDGV----PHLILIASRDIAAGEELLYDY 328
Cdd:cd10525   159 GN-ISHFVNHSCDPNLQVYNVFIDNLderlPRIALFATRTIRAGEELTFDY 208
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 216-343 4.51e-12

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 64.91  E-value: 4.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTgcYMYYFQYLSKTYCVDATQETNrLGRLINHSKCG 295
Cdd:cd10532    93 NGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGIT--YLFDLDYESDEFTVDAARYGN-VSHFVNHSCDP 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958669619 296 NCQTKLHDIDG----VPHLILIASRDIAAGEELLYDY-----GDRSKASIEAYPWLK 343
Cdd:cd10532   170 NLQVFNVFIDNldtrLPRIALFSTRTIKAGEELTFDYqmkgsGDLSSDSIDNSPAKK 226
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 207-328 6.98e-12

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 62.39  E-value: 6.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 207 EEGMKIDLI----DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQdpstgcYMYYFQY-LSKTYCVDATQE 281
Cdd:cd19217     1 QRGLKKHLLlapsDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDK------YMSSFLFnLNNDFVVDATRK 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958669619 282 TNRLgRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19217    75 GNKI-RFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDY 120
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 218-328 1.99e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 61.64  E-value: 1.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 218 KGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaQDPSTGCYMYYfqyLSKTYCVDATQeTNRLGRLINHSKCGNC 297
Cdd:cd19209    26 QGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIY-EEQNRGIYMFR---INNEHVIDATL-TGGPARYINHSCAPNC 100

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958669619 298 QTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19209   101 VAEVVTFDKEDKIIIISSRRIPKGEELTYDY 131
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 216-328 1.31e-10

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 58.78  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYfqyLSKTYCVDATQETNrLGRLINHSKCG 295
Cdd:cd19212    10 ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLT---VTKDRIIDAGPKGN-YSRFMNHSCNP 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958669619 296 NCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19212    86 NCETQKWTVNGDVRVGLFALCDIPAGMELTFNY 118
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 199-331 6.60e-10

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 58.41  E-value: 6.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 199 DELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREA---LYAQDPSTGcymyyfqylsKTYC 275
Cdd:cd10535    82 NRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEdsyLFDLDNKDG----------EVYC 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958669619 276 VDATQETNrLGRLINHskcgNCQTKL--------HDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd10535   152 IDARFYGN-VSRFINH----HCEPNLvpvrvfmaHQDLRFPRIAFFSTRLIEAGEQLGFDYGER 210
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 199-331 8.14e-10

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 58.49  E-value: 8.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 199 DELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREalyaqDPStgcymYYFQYLSK---TYC 275
Cdd:cd10533    82 NRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE-----DDS-----YLFDLDNKdgeVYC 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958669619 276 VDATQETNrLGRLINHSkcgnCQTK--------LHDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd10533   152 IDARYYGN-ISRFINHL----CDPNiipvrvfmLHQDLRFPRIAFFSSRDIRTGEELGFDYGDR 210
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 218-328 9.46e-10

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 56.56  E-value: 9.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 218 KGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYaQDPSTGCYMYYfqyLSKTYCVDATQeTNRLGRLINHSKCGNC 297
Cdd:cd19208    25 QGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLY-ESQNRGVYMFR---IDNDHVIDATL-TGGPARYINHSCAPNC 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958669619 298 QTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19208   100 VAEVVTFEKGHKIIISSSRRIQKGEELCYDY 130
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 216-337 2.96e-09

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 54.31  E-value: 2.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 216 DGKGRGVIATKRFSRGDFV------VEYHGDLIEITDakkrealyaQDPSTGCYMYyfqylsktycvdatqetnRLGRLI 289
Cdd:cd20071     7 GSKGRGLVATRDIEPGELIlvekplVSVPSNSFSLTD---------GLNEIGVGLF------------------PLASLL 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958669619 290 NHSKCGNCqtkLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIE 337
Cdd:cd20071    60 NHSCDPNA---VVVFDGNGTLRVRALRDIKAGEELTISYIDPLLPRTE 104
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 217-328 5.95e-09

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 54.16  E-value: 5.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 217 GKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKReALYAQDPSTGcyMYYFQYLSKTYCVDATQETNRlGRLINHSKCGN 296
Cdd:cd19210    11 GRGWGLRCKTDIKKGEFVNEYVGELIDEEECRAR-IRYAQEHDIT--NFYMLTLDKDRIIDAGPKGNY-ARFMNHCCQPN 86

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958669619 297 CQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19210    87 CETQKWTVNGDTRVGLFALCDIKAGTELTFNY 118
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 220-324 6.36e-09

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 53.43  E-value: 6.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 220 RGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQ-DPSTgcyMYYFQYLSKTYCVDATQETNrLGRLINHSKCGNCQ 298
Cdd:cd10529    17 KGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFKRpSPFV---FFYDGFEGLPLCVDARKYGN-EARFIRRSCRPNAE 92

                          90       100
                  ....*....|....*....|....*....
gi 1958669619 299 tkLH---DIDGVPHLILIASRDIAAGEEL 324
Cdd:cd10529    93 --LRhvvVSNGELRLFIFALKDIRKGTEI 119
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 215-333 9.18e-09

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 52.64  E-value: 9.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 215 IDGKGRGVIATKRFSRGDFVVEYHgdLIEITDAKkrealYAQDPSTGCYMYYFQYLSKTYCVDATqetnrLGRLINHSKC 294
Cdd:cd10540     7 STLKGRGVFATRPIKKGEVIEEAP--VIVLPKEE-----YQHLCKTVLDHYVFSWGDGCLALALG-----YGSMFNHSYT 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958669619 295 GNCQTKLHDIDGVphLILIASRDIAAGEELLYDYGDRSK 333
Cdd:cd10540    75 PNAEYEIDFENQT--IVFYALRDIEAGEELTINYGDDLW 111
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 218-330 5.40e-08

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 51.13  E-value: 5.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 218 KGRGVIATKRFSRGDFVVEYHGDLIEITDAKKrealyaQDPSTGCYMYYFQYLSKtycvdatQETNRL----GRLINHSK 293
Cdd:cd10524    18 YGAKIIATKPIKKGEKIHELCGCIAELSEEEE------ALLRPGGNDFSVMYSSR-------KKCSQLwlgpAAFINHDC 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958669619 294 CGNCQTKLHDIDGVphlILIASRDIAAGEELLYDYGD 330
Cdd:cd10524    85 RPNCKFVPTGKSTA---CVKVLRDIEPGEEITVYYGD 118
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 199-331 5.76e-08

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 52.96  E-value: 5.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 199 DELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTgcYMYYFQY----LSKTY 274
Cdd:cd20073    84 NRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVT--YLFDLDLfedqVDEYY 161

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958669619 275 CVDAtQETNRLGRLINHSKCGNCQTKL----HDIDGVPHLILIASRDIAAGEELLYDYGDR 331
Cdd:cd20073   162 TVDA-QYCGDVTRFINHSCDPNLAIYSvlrdKSDSKIYDLAFFAIKDIPALEELTFDYSGR 221
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 221-328 7.82e-08

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 51.18  E-value: 7.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 221 GVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYfqyLSKTYCVDATQETNrLGRLINHSKCGNCQTK 300
Cdd:cd19204    27 GLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIGSSYLFR---VDHDTIIDATKCGN-LARFINHCCTPNCYAK 102

                          90       100
                  ....*....|....*....|....*...
gi 1958669619 301 LHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19204   103 VITIESQKKIVIYSKQPIGVNEEITYDY 130
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 288-332 5.55e-07

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 49.76  E-value: 5.55e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958669619 288 LINHS-KCGNCQtkLHDIDGVPHLILIASRDIAAGEELLYDYGDRS 332
Cdd:cd10527   182 MLNHSpDAPNVR--YEYDEDEGSFVLVATRDIAAGEEVFISYGPKS 225
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 199-329 1.40e-06

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 48.69  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 199 DELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDpstgcymyYFQYLSK----TY 274
Cdd:cd10541    83 NRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLEMGDE--------YFANLDHieesCY 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 275 CVDATQETNrLGRLINHSKCGNCQTK-----LHDIDgVPHLILIASRDIAAGEELLYDYG 329
Cdd:cd10541   155 IIDAKLEGN-LGRYLNHSCSPNLFVQnvfvdTHDLR-FPWVAFFASKRIKAGTELTWDYN 212
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 222-328 4.16e-06

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 45.86  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 222 VIATKRFSRGDFVVEYHGDLIEITDAKK------REALYAQDPSTGCYMyyfqylsktyCVDatqETNRLGRLI----NH 291
Cdd:cd10539    18 VEADGFIKDLTIIAEYTGDVDYIRNREFddndsiMTLLLAGDPSKSLVI----------CPD---KRGNIARFIsginNH 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958669619 292 SKCG----NCQTKLHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd10539    85 TKDGkkkqNCKCVRYSINGEARVLLVATRDIAKGERLYYDY 125
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 218-329 5.34e-06

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 47.01  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 218 KGRGVIATKRFSRGDFVVEYHGDLIEITDAKKR---------------------EALYAQDPSTGCYMYYFQYLSKTYCV 276
Cdd:cd10545    96 RGWGVRSWDSIPAGSFICEYVGELLDTSEADTRsgnddylfdidnrqtnrgwdgGQRLDVGMSDGERSSAEDEESSEFTI 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958669619 277 DATQETNrLGRLINHSkcgnCQTKL---------HDIDgVPHLILIASRDIAAGEELLYDYG 329
Cdd:cd10545   176 DAGSFGN-VARFINHS----CSPNLfvqcvlydhNDLR-LPRVMLFAADNIPPLQELTYDYG 231
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 221-328 5.65e-06

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 45.82  E-value: 5.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 221 GVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSktyCVDATQETNrLGRLINHSKCGNCQTK 300
Cdd:cd19205    27 GLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDT---IIDATKCGN-FARFINHSCNPNCYAK 102

                          90       100
                  ....*....|....*....|....*...
gi 1958669619 301 LHDIDGVPHLILIASRDIAAGEELLYDY 328
Cdd:cd19205   103 VITVESQKKIVIYSKQHINVNEEITYDY 130
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 221-329 1.64e-05

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 44.70  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 221 GVIATKRFSRGDFVVEYHGDLieitdakKREALYAQDPSTgcyMYYFQYLSKTY---------CVDaTQETNRLGRLINH 291
Cdd:cd19183    15 GLFADRPIPAGDPIQELLGEI-------GLQSEYIADPEN---QYQILGAPKPHvffhpqsplYID-TRRSGSVARFIRR 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958669619 292 SKCGNCQ--TKLHDIDGVPHLILIASRDIAAGEELLYDYG 329
Cdd:cd19183    84 SCRPNAElvTVASDSGSVLKFVLYASRDISPGEEITIGWD 123
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 240-329 6.24e-05

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 44.20  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 240 DLIEITDAKKREalYAQDPSTGCYMyyfqylsktycVDATQETNrLGRLINHSKCGNCQT-----KLHDIDgVPHLILIA 314
Cdd:cd10517   184 DYIEVVEKLKEG--YESDVEEHCYI-----------IDAKSEGN-LGRYLNHSCSPNLFVqnvfvDTHDLR-FPWVAFFA 248

                          90
                  ....*....|....*
gi 1958669619 315 SRDIAAGEELLYDYG 329
Cdd:cd10517   249 SRYIRAGTELTWDYN 263
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 218-329 7.68e-04

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 40.59  E-value: 7.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958669619 218 KGRGVIATKRFSRGDFVVEYHGDLI------EITDAKKREALYAQDPSTGCYMYYFQYLSK----TYCVDATQETNrLGR 287
Cdd:cd10523   118 KGWGVRCLDDIDKGTFVCIYAGRVLsrarspTEPLPPKLELPSENEVEVVTSWLILSKKRKlrenVCFLDASKEGN-VGR 196

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958669619 288 LINHSKCGN--CQ---TKLHDiDGVPHLILIASRDIAAGEELLYDYG 329
Cdd:cd10523   197 FLNHSCCPNlfVQnvfVDTHD-KNFPWVAFFTNRVVKAGTELTWDYS 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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