hematopoietic SH2 domain-containing protein isoform X2 [Rattus norvegicus]
Protein Classification
SH2 domain-containing protein( domain architecture ID 61889)
SH2 (Src homology 2) domain-containing protein may act as an intracellular signal-transducing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SH2 super family | cl15255 | Src homology 2 (SH2) domain; In general, SH2 domains are involved in signal transduction; they ... |
1-47 | 4.23e-22 | ||
Src homology 2 (SH2) domain; In general, SH2 domains are involved in signal transduction; they bind pTyr-containing polypeptide ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. They are present in a wide array of proteins including: adaptor proteins (Nck1, Crk, Grb2), scaffolds (Slp76, Shc, Dapp1), kinases (Src, Syk, Fps, Tec), phosphatases (Shp-1, Shp-2), transcription factors (STAT1), Ras signaling molecules (Ras-Gap), ubiquitination factors (c-Cbl), cytoskeleton regulators (Tensin), signal regulators (SAP), and phospholipid second messengers (PLCgamma), amongst others. The actual alignment was detected with superfamily member cd09946: Pssm-ID: 472789 Cd Length: 102 Bit Score: 87.64 E-value: 4.23e-22
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| Name | Accession | Description | Interval | E-value | ||
| SH2_HSH2_like | cd09946 | Src homology 2 domain found in hematopoietic SH2 (HSH2) protein; HSH2 is thought to function ... |
1-47 | 4.23e-22 | ||
Src homology 2 domain found in hematopoietic SH2 (HSH2) protein; HSH2 is thought to function as an adapter protein involved in tyrosine kinase signaling. It may also be involved in regulating cytokine signaling and cytoskeletal reorganization in hematopoietic cells. HSH2 contains several putative protein-binding motifs, SH3-binding proline-rich regions, and phosphotyrosine sites, but lacks enzymatic motifs. HSH2 was found to interact with cytokine-regulated tyrosine kinase c-FES and an activated Cdc42-associated tyrosine kinase ACK1. HSH2 binds c-FES through both its C-terminal region and its N-terminal region including the SH2 domain and binds ACK1 via its N-terminal proline-rich region. Both kinases bound and tyrosine-phosphorylated HSH2 in mammalian cells. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. Pssm-ID: 198199 Cd Length: 102 Bit Score: 87.64 E-value: 4.23e-22
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| Name | Accession | Description | Interval | E-value | ||
| SH2_HSH2_like | cd09946 | Src homology 2 domain found in hematopoietic SH2 (HSH2) protein; HSH2 is thought to function ... |
1-47 | 4.23e-22 | ||
Src homology 2 domain found in hematopoietic SH2 (HSH2) protein; HSH2 is thought to function as an adapter protein involved in tyrosine kinase signaling. It may also be involved in regulating cytokine signaling and cytoskeletal reorganization in hematopoietic cells. HSH2 contains several putative protein-binding motifs, SH3-binding proline-rich regions, and phosphotyrosine sites, but lacks enzymatic motifs. HSH2 was found to interact with cytokine-regulated tyrosine kinase c-FES and an activated Cdc42-associated tyrosine kinase ACK1. HSH2 binds c-FES through both its C-terminal region and its N-terminal region including the SH2 domain and binds ACK1 via its N-terminal proline-rich region. Both kinases bound and tyrosine-phosphorylated HSH2 in mammalian cells. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. Pssm-ID: 198199 Cd Length: 102 Bit Score: 87.64 E-value: 4.23e-22
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| SH2_SH2D7 | cd10417 | Src homology 2 domain found in the SH2 domain containing protein 7 (SH2D7); SH2D7 contains a ... |
6-45 | 3.24e-05 | ||
Src homology 2 domain found in the SH2 domain containing protein 7 (SH2D7); SH2D7 contains a single SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. Pssm-ID: 199832 Cd Length: 102 Bit Score: 41.80 E-value: 3.24e-05
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| SH2_SH2D4A | cd10350 | Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A); SH2D4A contains ... |
4-47 | 5.18e-03 | ||
Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A); SH2D4A contains a single SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites. Pssm-ID: 198213 Cd Length: 103 Bit Score: 35.68 E-value: 5.18e-03
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