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Conserved domains on  [gi|1958734618|ref|XP_038952372|]
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kelch-like protein 3 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
96-352 4.19e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 181.89  E-value: 4.19e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  96 WDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASM-QERRSTLGAAVLNDLLYAVGGFDG- 173
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 174 ---STGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRqcLSTVEQYNPATNEWIYVADMSTRRS 250
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 251 GAGVGVL-SGQLYATGGHDGplvrksvevyDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPV 329
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|...
gi 1958734618 330 TDKWTLLPtNMSTGRSYAGVAVI 352
Cdd:COG3055   229 TNTWTALG-ELPTPRHGHAAVLT 250
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 1-45 2.94e-28

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18513:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 130  Bit Score: 107.07  E-value: 2.94e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 45
Cdd:cd18513    86 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
Kelch smart00612
Kelch domain;
71-116 1.34e-06

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 1.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958734618   71 VMIVVGGQAPK-AIRSVECYDFEEGRWDQIAELPSRRCRAGVVFMAG 116
Cdd:smart00612   1 KIYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
96-352 4.19e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 181.89  E-value: 4.19e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  96 WDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASM-QERRSTLGAAVLNDLLYAVGGFDG- 173
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 174 ---STGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRqcLSTVEQYNPATNEWIYVADMSTRRS 250
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 251 GAGVGVL-SGQLYATGGHDGplvrksvevyDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPV 329
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|...
gi 1958734618 330 TDKWTLLPtNMSTGRSYAGVAVI 352
Cdd:COG3055   229 TNTWTALG-ELPTPRHGHAAVLT 250
PHA03098 PHA03098
kelch-like protein; Provisional
 88-335 4.29e-40

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 148.38  E-value: 4.29e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  88 CYDFEEGRWDQIAELPSRRCrAGVVFMAGHVYAVGGFNGS-LRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLY 166
Cdd:PHA03098  268 TNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIY 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 167 AVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG---YDgasrQCLSTVEQYNPATNEWIYVA 243
Cdd:PHA03098  347 VIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskND----ELLKTVECFSLNTNKWSKGS 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 244 DMSTRRSGAGVGVLSGQLYATGGH---DGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 320
Cdd:PHA03098  423 PLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYI 502

                         250
                  ....*....|....*
gi 1958734618 321 ASVEYYNPVTDKWTL 335
Cdd:PHA03098  503 NEIEVYDDKTNTWTL 517
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 1-45 2.94e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 107.07  E-value: 2.94e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 45
Cdd:cd18513    86 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
Kelch smart00612
Kelch domain;
260-306 5.54e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.35  E-value: 5.54e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958734618  260 QLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNG 306
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 296-340 1.35e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.47  E-value: 1.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958734618 296 RRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNM 340
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
71-116 1.34e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 1.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958734618   71 VMIVVGGQAPK-AIRSVECYDFEEGRWDQIAELPSRRCRAGVVFMAG 116
Cdd:smart00612   1 KIYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 1-23 7.26e-04

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 38.68  E-value: 7.26e-04
                          10        20
                  ....*....|....*....|...
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVE 23
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 59-103 1.65e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958734618  59 RTKPRTPVSLPKVMIVVGGQ-APKAIRSVECYDFEEGRWDQIAELP 103
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFdGNQSLNSVEVYDPETNTWSKLPSMP 46
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 204-290 7.14e-03

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 38.07  E-value: 7.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 204 GVG-VVEGKLYAVGGYDGASRQCLSTveqyNPATNEWIYVADMST-RRSGAGVGVLSGQLYATGG-----HDGPL-VRKS 275
Cdd:TIGR03547  11 GTGaIIGDKVYVGLGSAGTSWYKLDL----KKPSKGWQKIADFPGgPRNQAVAAAIDGKLYVFGGigkanSEGSPqVFDD 86

                          90
                  ....*....|....*
gi 1958734618 276 VEVYDPGTNTWKQVA 290
Cdd:TIGR03547  87 VYRYDPKKNSWQKLD 101
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
96-352 4.19e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 181.89  E-value: 4.19e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  96 WDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASM-QERRSTLGAAVLNDLLYAVGGFDG- 173
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 174 ---STGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRqcLSTVEQYNPATNEWIYVADMSTRRS 250
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 251 GAGVGVL-SGQLYATGGHDGplvrksvevyDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPV 329
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|...
gi 1958734618 330 TDKWTLLPtNMSTGRSYAGVAVI 352
Cdd:COG3055   229 TNTWTALG-ELPTPRHGHAAVLT 250
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
74-313 1.28e-49

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 167.64  E-value: 1.28e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  74 VVGGQAP-KAIRSVECYDFEEGRWDQIAELP-SRRCRAGVVFMAGHVYAVGGFNGSLRVRT----VDVYDGVKDQWTSIA 147
Cdd:COG3055    27 VAGGLSGgSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSSTplndVYVYDPATNTWTKLA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 148 SMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVV-EGKLYAVGGYDGasrqcl 226
Cdd:COG3055   107 PMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG------ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 227 stveqyNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLvrKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNG 306
Cdd:COG3055   181 ------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252


                  ....*..
gi 1958734618 307 LLYVVGG 313
Cdd:COG3055   253 KVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
74-280 8.28e-42

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 147.22  E-value: 8.28e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  74 VVGG-----QAPKAIRSVECYDFEEGRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIAS 148
Cdd:COG3055    75 VFGGftganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 149 MQERRSTLGAAVL-NDLLYAVGGFDGSTGlasveaysykTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASrqclS 227
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS----D 220

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958734618 228 TVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKS----VEVYD 280
Cdd:COG3055   221 EVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPlvtsAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 88-335 4.29e-40

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 148.38  E-value: 4.29e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  88 CYDFEEGRWDQIAELPSRRCrAGVVFMAGHVYAVGGFNGS-LRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLY 166
Cdd:PHA03098  268 TNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIY 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 167 AVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG---YDgasrQCLSTVEQYNPATNEWIYVA 243
Cdd:PHA03098  347 VIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskND----ELLKTVECFSLNTNKWSKGS 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 244 DMSTRRSGAGVGVLSGQLYATGGH---DGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 320
Cdd:PHA03098  423 PLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYI 502

                         250
                  ....*....|....*
gi 1958734618 321 ASVEYYNPVTDKWTL 335
Cdd:PHA03098  503 NEIEVYDDKTNTWTL 517
PHA03098 PHA03098
kelch-like protein; Provisional
 136-356 3.78e-31

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 123.34  E-value: 3.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 136 YDGVKDQWTSIASMQERRStLGAAVLNDLLYAVGGFDGS-TGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYA 214
Cdd:PHA03098  269 NYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYV 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 215 VGGYDGASRqcLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG-HDGPLVRKSVEVYDPGTNTWKQVADMN 293
Cdd:PHA03098  348 IGGIYNSIS--LNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLP 425

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958734618 294 McrRNAGVCAV--NGLLYVVGG---DDGSCNLASVEYYNPVTDKWTLLPTnMSTGRSYAGVAVIHKSL 356
Cdd:PHA03098  426 I--SHYGGCAIyhDGKIYVIGGisyIDNIKVYNIVESYNPVTNKWTELSS-LNFPRINASLCIFNNKI 490
PHA03098 PHA03098
kelch-like protein; Provisional
 78-291 5.36e-29

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 117.18  E-value: 5.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  78 QAPKAIRSVECYDFEEGRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLG 157
Cdd:PHA03098  305 KNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPC 384

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 158 AAVLNDLLYAVGG-FDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASR-QCLSTVEQYNPA 235
Cdd:PHA03098  385 VVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNiKVYNIVESYNPV 464

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958734618 236 TNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVAD 291
Cdd:PHA03098  465 TNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 1-45 2.94e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 107.07  E-value: 2.94e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 45
Cdd:cd18513    86 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 1-45 1.17e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 94.71  E-value: 1.17e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 45
Cdd:cd18512    86 MAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
70-233 8.36e-23

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 96.38  E-value: 8.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  70 KVMIVVGGQAPKAIRSVECYDFEEGRWDQIAELPSRRCR-AGVVFMAGHVYAVGGFNGSlrvrtvdvydGVKDQWTSIAS 148
Cdd:COG3055   123 KIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGS----------GFSNTWTTLAP 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 149 MQERRSTLGAAVLNDLLYAVGGFDGStgLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD--GASRQCL 226
Cdd:COG3055   193 LPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETkpGVRTPLV 270


                  ....*..
gi 1958734618 227 STVEQYN 233
Cdd:COG3055   271 TSAEVYD 277
Kelch smart00612
Kelch domain;
260-306 5.54e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.35  E-value: 5.54e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958734618  260 QLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNG 306
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
164-210 1.81e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.81  E-value: 1.81e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958734618  164 LLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEG 210
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
211-259 5.87e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 65.27  E-value: 5.87e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958734618  211 KLYAVGGYDGAsrQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSG 259
Cdd:smart00612   1 KIYVVGGFDGG--QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PLN02193 PLN02193
nitrile-specifier protein
 94-289 1.05e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 71.91  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  94 GRW---DQIAELPSRRCRAGVVFMAGHVYAVGG-FNGSLRV-RTVDVYDGVKDQWtSIASMQ---ERRSTLGAAVLN--D 163
Cdd:PLN02193  151 GKWikvEQKGEGPGLRCSHGIAQVGNKIYSFGGeFTPNQPIdKHLYVFDLETRTW-SISPATgdvPHLSCLGVRMVSigS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 164 LLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMN---TRRSSVGVGVVEGKLYAVGGYDGASRqcLSTVEQYNPATNEWI 240
Cdd:PLN02193  230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATAR--LKTLDSYNIVDKKWF 307

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958734618 241 YVA---DMSTRRSGAGVGVLSGQLYATGGHDGPLVrKSVEVYDPGTNTWKQV 289
Cdd:PLN02193  308 HCStpgDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQV 358
Kelch smart00612
Kelch domain;
307-354 1.18e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.50  E-value: 1.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958734618  307 LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPtNMSTGRSYAGVAVIHK 354
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
117-163 7.14e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.19  E-value: 7.14e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958734618  117 HVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLND 163
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 296-340 1.35e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.47  E-value: 1.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958734618 296 RRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNM 340
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 199-246 3.18e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 60.70  E-value: 3.18e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958734618 199 RRSSVGVGVVEGKLYAVGGYDGasRQCLSTVEQYNPATNEWIYVADMS 246
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG--NQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 1-29 3.74e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 62.25  E-value: 3.74e-12
                          10        20
                  ....*....|....*....|....*....
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVEEEALIK 29
Cdd:cd18445    86 LAELLEHVRLPLLSPEYLVQRVEEEELIK 114
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 248-293 7.07e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.55  E-value: 7.07e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958734618 248 RRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMN 293
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 152-197 3.32e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.62  E-value: 3.32e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958734618 152 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMN 197
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 105-150 7.52e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.47  E-value: 7.52e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958734618 105 RRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQ 150
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PHA02713 PHA02713
hypothetical protein; Provisional
 183-354 1.30e-10

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 62.72  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 183 YSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDgASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLY 262
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYN-FNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIY 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 263 ATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY----------------- 325
Cdd:PHA02713  356 AIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVHHmnsidmeedthssnkvi 435

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958734618 326 -YNPVTDKWTLLPtNMSTGRSYAGVaVIHK 354
Cdd:PHA02713  436 rYDTVNNIWETLP-NFWTGTIRPGV-VSHK 463
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
285-353 4.41e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 59.78  E-value: 4.41e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958734618 285 TWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIH 353
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQD 70
PLN02153 PLN02153
epithiospecifier protein
 153-354 2.49e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 58.07  E-value: 2.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 153 RSTLGAAVLNDLLYAVGGFDGSTGLASVEAY--SYKTNEWFfVAPMN---TRRSSVGVGVVE--GKLYAVGGYDgaSRQC 225
Cdd:PLN02153   23 RCSHGIAVVGDKLYSFGGELKPNEHIDKDLYvfDFNTHTWS-IAPANgdvPRISCLGVRMVAvgTKLYIFGGRD--EKRE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 226 LSTVEQYNPATNEWIYVADMSTR-----RSGAGVGVLSGQLYATGG------HDGPLVRKSVEVYDPGTNTWKQVAD--M 292
Cdd:PLN02153  100 FSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYNIADGKWVQLPDpgE 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958734618 293 NMCRRN-AGVCAVNGLLYVV----------GGDDGSCNlaSVEYYNPVTDKWTLLPTNMS--TGRSYAGVAVIHK 354
Cdd:PLN02153  180 NFEKRGgAGFAVVQGKIWVVygfatsilpgGKSDYESN--AVQFFDPASGKWTEVETTGAkpSARSVFAHAVVGK 252
PLN02153 PLN02153
epithiospecifier protein
 93-289 2.83e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 57.69  E-value: 2.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  93 EGRWDQIAEL----PSRRCRAGVVFMAGHVYAVGG-FNGSLRV-RTVDVYDGVKDQWtSIASMQ---ERRSTLGA--AVL 161
Cdd:PLN02153    6 QGGWIKVEQKggkgPGPRCSHGIAVVGDKLYSFGGeLKPNEHIdKDLYVFDFNTHTW-SIAPANgdvPRISCLGVrmVAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 162 NDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTR-----RSSVGVGVVEGKLYAVGGYDGASRQC----LSTVEQY 232
Cdd:PLN02153   85 GTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGGLMKtperFRTIEAY 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958734618 233 NPATNEWIYVADMS---TRRSGAGVGVLSGQLYATGGHDGPLV--------RKSVEVYDPGTNTWKQV 289
Cdd:PLN02153  165 NIADGKWVQLPDPGenfEKRGGAGFAVVQGKIWVVYGFATSILpggksdyeSNAVQFFDPASGKWTEV 232
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 1-48 4.88e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 54.33  E-value: 4.88e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 48
Cdd:cd18452    86 LPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133
PHA02790 PHA02790
Kelch-like protein; Provisional
 118-335 2.50e-08

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 55.43  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 118 VYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTglaSVEAYSYKTNEWFFVAPMN 197
Cdd:PHA02790  274 VYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPT---SVERWFHGDAAWVNMPSLL 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 198 TRRSSVGVGVVEGKLYAVGGYDGASrqclSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYatgghdgpLVRKSVE 277
Cdd:PHA02790  351 KPRCNPAVASINNVIYVIGGHSETD----TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLF--------LVGRNAE 418

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958734618 278 VYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTL 335
Cdd:PHA02790  419 FYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
PLN02193 PLN02193
nitrile-specifier protein
 89-270 5.29e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 54.19  E-value: 5.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  89 YDFEEGRWD---QIAELPSRRCrAGV--VFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQE---RRSTLGAAV 160
Cdd:PLN02193  198 FDLETRTWSispATGDVPHLSC-LGVrmVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAA 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 161 LNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVA-PMN--TRRSSVGVGVVEGKLYAVGGYDGASrqcLSTVEQYNPATN 237
Cdd:PLN02193  277 DEENVYVFGGVSATARLKTLDSYNIVDKKWFHCStPGDsfSIRGGAGLEVVQGKVWVVYGFNGCE---VDDVHYYDPVQD 353

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1958734618 238 EWIYVADMSTR---RSGAGVGVLSGQLYATGG--------HDGP 270
Cdd:PLN02193  354 KWTQVETFGVRpseRSVFASAAVGKHIVIFGGeiamdplaHVGP 397
Kelch smart00612
Kelch domain;
71-116 1.34e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 1.34e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958734618   71 VMIVVGGQAPK-AIRSVECYDFEEGRWDQIAELPSRRCRAGVVFMAG 116
Cdd:smart00612   1 KIYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02713 PHA02713
hypothetical protein; Provisional
 101-170 2.61e-06

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 49.24  E-value: 2.61e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958734618 101 ELP---SRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGG 170
Cdd:PHA02713  334 ELPpmiKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
PHA02713 PHA02713
hypothetical protein; Provisional
 149-217 5.48e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.00  E-value: 5.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958734618 149 MQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG 217
Cdd:PHA02713  338 MIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 199-245 5.79e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 40.01  E-value: 5.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958734618 199 RRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADM 245
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEVPRL 47
Kelch_6 pfam13964
Kelch motif;
207-249 7.26e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 7.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958734618 207 VVEGKLYAVGGYDGASRQcLSTVEQYNPATNEWIYVADMSTRR 249
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPA-LNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
209-254 1.56e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.81  E-value: 1.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958734618 209 EGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGV 254
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSA 46
PLN02153 PLN02153
epithiospecifier protein
 238-336 2.57e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 42.67  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 238 EWIYVADMSTR----RSGAGVGVLSGQLYATGGHDGP--LVRKSVEVYDPGTNTWkQVADMN-----MCRRNAGVCAVNG 306
Cdd:PLN02153    8 GWIKVEQKGGKgpgpRCSHGIAVVGDKLYSFGGELKPneHIDKDLYVFDFNTHTW-SIAPANgdvprISCLGVRMVAVGT 86

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958734618 307 LLYVVGGDDGSCNLASVEYYNPVTDKWTLL 336
Cdd:PLN02153   87 KLYIFGGRDEKREFSDFYSYDTVKNEWTFL 116
Kelch_3 pfam13415
Galactose oxidase, central domain;
259-304 4.94e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.65  E-value: 4.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958734618 259 GQLYATGG--HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAV 304
Cdd:pfam13415   2 DKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 1-23 7.26e-04

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 38.68  E-value: 7.26e-04
                          10        20
                  ....*....|....*....|...
gi 1958734618   1 MAKLMEHVRLPLLPRDYLVQTVE 23
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
Kelch_6 pfam13964
Kelch motif;
295-344 8.93e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.93  E-value: 8.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958734618 295 CRRNAGVCAVNGLLYVVGGDDGSCN-LASVEYYNPVTDKWTLLPtNMSTGR 344
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELP-PLPTPR 50
PRK14131 PRK14131
N-acetylneuraminate epimerase;
204-313 1.35e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.38  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 204 GVG-VVEGKLYaVG-GYDGASRQCLSTveqyNPATNEWIYVADM-STRRSGAGVGVLSGQLYATGG-----HDGPL-VRK 274
Cdd:PRK14131   32 GTGaIDNNTVY-VGlGSAGTSWYKLDL----NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSPqVFD 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958734618 275 SVEVYDPGTNTWKQVadmnMCRR------NAGVCAVNGLLYVVGG 313
Cdd:PRK14131  107 DVYKYDPKTNSWQKL----DTRSpvglagHVAVSLHNGKAYITGG 147
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 59-103 1.65e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958734618  59 RTKPRTPVSLPKVMIVVGGQ-APKAIRSVECYDFEEGRWDQIAELP 103
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFdGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
259-293 2.13e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.77  E-value: 2.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958734618 259 GQLYATGGHDGPLVRKS-VEVYDPGTNTWKQVADMN 293
Cdd:pfam13964  12 GYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPLP 47
PRK14131 PRK14131
N-acetylneuraminate epimerase;
286-338 2.46e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 39.61  E-value: 2.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 286 WKQVADMNMCRRNAGVCA-VNGLLYVVGG-----DDGSCNLASVEY-YNPVTDKWTLLPT 338
Cdd:PRK14131   64 WTKIAAFPGGPREQAVAAfIDGKLYVFGGigktnSEGSPQVFDDVYkYDPKTNSWQKLDT 123
PLN02153 PLN02153
epithiospecifier protein
 80-170 2.61e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 39.20  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618  80 PKAIRSVECYDFEEGRWDQI---AELPSRRCRAGVVFMAGHVYAVGGFNGSL--------RVRTVDVYDGVKDQWTSIAS 148
Cdd:PLN02153  155 PERFRTIEAYNIADGKWVQLpdpGENFEKRGGAGFAVVQGKIWVVYGFATSIlpggksdyESNAVQFFDPASGKWTEVET 234

                          90       100
                  ....*....|....*....|....*
gi 1958734618 149 MQER---RSTLGAAVLNDLLYAVGG 170
Cdd:PLN02153  235 TGAKpsaRSVFAHAVVGKYIIIFGG 259
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 248-292 3.44e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 3.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958734618 248 RRSGAGVGVLSGQLYATGGHD--GPLVRKSVEVYDPGTNTWKQVADM 292
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWTEVPRL 47
Kelch_6 pfam13964
Kelch motif;
158-200 5.70e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 5.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958734618 158 AAVLNDLLYAVGGF-DGSTGLASVEAYSYKTNEWFFVAPMNTRR 200
Cdd:pfam13964   7 VVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
305-352 6.66e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.19  E-value: 6.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958734618 305 NGLLYVVGGDDGSCNLASVEY--YNPVTDKWTLLPTnMSTGRSYAGVAVI 352
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLyvYDLDTNTWTQIGD-LPPPRSGHSATYI 49
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 204-290 7.14e-03

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 38.07  E-value: 7.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 204 GVG-VVEGKLYAVGGYDGASRQCLSTveqyNPATNEWIYVADMST-RRSGAGVGVLSGQLYATGG-----HDGPL-VRKS 275
Cdd:TIGR03547  11 GTGaIIGDKVYVGLGSAGTSWYKLDL----KKPSKGWQKIADFPGgPRNQAVAAAIDGKLYVFGGigkanSEGSPqVFDD 86

                          90
                  ....*....|....*
gi 1958734618 276 VEVYDPGTNTWKQVA 290
Cdd:TIGR03547  87 VYRYDPKKNSWQKLD 101
WD40 COG2319
WD40 repeat [General function prediction only];
210-317 7.40e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.97  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734618 210 GKLYAVGGYDGasrqclsTVEQYNPATNEWIyvadmsTRRSGAGVGVLS------GQLYATGGHDGplvrkSVEVYDPGT 283
Cdd:COG2319   216 GKLLASGSADG-------TVRLWDLATGKLL------RTLTGHSGSVRSvafspdGRLLASGSADG-----TVRLWDLAT 277

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958734618 284 NTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGS 317
Cdd:COG2319   278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311
Kelch_6 pfam13964
Kelch motif;
106-153 7.44e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 7.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958734618 106 RCRAGVVFMAGHVYAVGGF-NGSLRVRTVDVYDGVKDQWTSIASMQERR 153
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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