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Conserved domains on  [gi|1958807934|ref|XP_038955875|]
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zinc finger X-chromosomal protein isoform X3 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein; C2H2-type zinc finger protein; C2H2-type zinc finger protein; C2H2-type zinc finger protein; KRAB domain-containing zinc finger protein; C2H2-type zinc finger protein; KRAB domain-containing zinc finger protein; KRAB domain-containing zinc finger protein( domain architecture ID 12656255)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Mus musculus zinc finger protein 574 (ZNF574); Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens zinc finger protein 513 (ZNF513), a transcriptional regulator that plays a role in retinal development and maintenance; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Mus musculus zinc finger protein 574 (ZNF574); Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens zinc finger protein 648 (ZNF648); Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Mus musculus Krueppel-like factor 10 isoform 2, which suppresses TGFbeta-induced EMT, establishing a molecular basis for the dichotomy of TGFbeta function during tumor progression; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 71-354 2.18e-151

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 443.92  E-value: 2.18e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934  71 DVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVSHVEH 150
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 151 VVHDSvvEAEIVTDPLTADVVSEEVLVADCASEAVIDANGVPVNQQDEDKANCEDYLMISC------------------- 211
Cdd:pfam04704  81 VIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLddgekldhigstpltmsae 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 212 -------------------------------GTVDIVESEPENEHGVELLDPNNSMRVPREKMVYMAVNDTQQEEEELNV 260
Cdd:pfam04704 159 veqdsskldgfcpevikvyifkadpgeddlgGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLNV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 261 AEIADEVYMEVIVGEEDaaaaaAAAVHEQQVEDNEM-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAK 339
Cdd:pfam04704 239 AEIADEVYMEVIVGEED-----AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRLLK 313

                         330
                  ....*....|....*
gi 1958807934 340 QKPKKRRRPDSRQYQ 354
Cdd:pfam04704 314 QKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-530 5.99e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.99e-05
                          10        20
                  ....*....|....*....|....*
gi 1958807934 506 ELKKHMRIHTGEKPYECQYCEYRSA 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
487-624 7.39e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 487 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 564
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807934 565 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKH 624
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
ROS_MUCR super family cl19880
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 321-401 4.53e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


The actual alignment was detected with superfamily member pfam05443:

Pssm-ID: 473244  Cd Length: 122  Bit Score: 40.52  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 321 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 396
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 1958807934 397 KKKYR 401
Cdd:pfam05443  88 PEEYR 92
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-701 9.91e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.91e-04
                          10        20
                  ....*....|....*....|....*
gi 1958807934 677 ELKKHMKTHSGRKVYQCEYCEYSTT 701
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 663-685 1.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|...
gi 1958807934 663 FRCKRCRKGFRQQSELKKHMKTH 685
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 71-354 2.18e-151

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 443.92  E-value: 2.18e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934  71 DVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVSHVEH 150
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 151 VVHDSvvEAEIVTDPLTADVVSEEVLVADCASEAVIDANGVPVNQQDEDKANCEDYLMISC------------------- 211
Cdd:pfam04704  81 VIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLddgekldhigstpltmsae 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 212 -------------------------------GTVDIVESEPENEHGVELLDPNNSMRVPREKMVYMAVNDTQQEEEELNV 260
Cdd:pfam04704 159 veqdsskldgfcpevikvyifkadpgeddlgGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLNV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 261 AEIADEVYMEVIVGEEDaaaaaAAAVHEQQVEDNEM-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAK 339
Cdd:pfam04704 239 AEIADEVYMEVIVGEED-----AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRLLK 313

                         330
                  ....*....|....*
gi 1958807934 340 QKPKKRRRPDSRQYQ 354
Cdd:pfam04704 314 QKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-530 5.99e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.99e-05
                          10        20
                  ....*....|....*....|....*
gi 1958807934 506 ELKKHMRIHTGEKPYECQYCEYRSA 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
487-624 7.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 487 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 564
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807934 565 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKH 624
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 321-401 4.53e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.52  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 321 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 396
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 1958807934 397 KKKYR 401
Cdd:pfam05443  88 PEEYR 92
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-701 9.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.91e-04
                          10        20
                  ....*....|....*....|....*
gi 1958807934 677 ELKKHMKTHSGRKVYQCEYCEYSTT 701
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
rne PRK10811
ribonuclease E; Reviewed
 33-195 1.44e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.33  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934   33 VVEVQETVYVSDVVDSDITVHNYVPDDPDSVVIQDVIEDVVIEDVqcTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHC 112
Cdd:PRK10811   847 VVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAV--AEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPV 924

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934  113 TVPDDVLASDITSASISMPEHV--LTSESIHVSDVSHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANG 190
Cdd:PRK10811   925 TEQPQVITESDVAVAQEVAEHAepVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPA 1004


                   ....*
gi 1958807934  191 VPVNQ 195
Cdd:PRK10811  1005 QVPEA 1009
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 492-514 1.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|...
gi 1958807934 492 HICVECGKGFRHPSELKKHMRIH 514
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 663-685 1.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|...
gi 1958807934 663 FRCKRCRKGFRQQSELKKHMKTH 685
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 71-354 2.18e-151

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 443.92  E-value: 2.18e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934  71 DVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVSHVEH 150
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 151 VVHDSvvEAEIVTDPLTADVVSEEVLVADCASEAVIDANGVPVNQQDEDKANCEDYLMISC------------------- 211
Cdd:pfam04704  81 VIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLddgekldhigstpltmsae 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 212 -------------------------------GTVDIVESEPENEHGVELLDPNNSMRVPREKMVYMAVNDTQQEEEELNV 260
Cdd:pfam04704 159 veqdsskldgfcpevikvyifkadpgeddlgGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLNV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 261 AEIADEVYMEVIVGEEDaaaaaAAAVHEQQVEDNEM-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAK 339
Cdd:pfam04704 239 AEIADEVYMEVIVGEED-----AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRLLK 313

                         330
                  ....*....|....*
gi 1958807934 340 QKPKKRRRPDSRQYQ 354
Cdd:pfam04704 314 QKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-530 5.99e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.99e-05
                          10        20
                  ....*....|....*....|....*
gi 1958807934 506 ELKKHMRIHTGEKPYECQYCEYRSA 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
487-624 7.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 487 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 564
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807934 565 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC-DKGFHRPSELKKH 624
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 321-401 4.53e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.52  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 321 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 396
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 1958807934 397 KKKYR 401
Cdd:pfam05443  88 PEEYR 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
455-598 5.72e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 455 KEKGANKMHKCKFCEYETAEQGLLNRHLLAVH---SKNFPHICVE--CGKGFRHPSELKKHMRIHTGEKPYECQYC---- 525
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsss 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934 526 ------------------------EYRSADSSNLKTHVKTKHSKEMP----------FKCDICLLTFSDTKEVQQHALIH 571
Cdd:COG5048   362 kfspllnneppqslqqykdlkndkKSETLSNSCIRNFKRDSNLSLHIithlsfrpynCKNPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*..
gi 1958807934 572 QESKTHQCLHCDhKSSNSSDLKRHIIS 598
Cdd:COG5048   442 TNHAPLLCSILK-SFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-701 9.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.91e-04
                          10        20
                  ....*....|....*....|....*
gi 1958807934 677 ELKKHMKTHSGRKVYQCEYCEYSTT 701
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
rne PRK10811
ribonuclease E; Reviewed
 33-195 1.44e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.33  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934   33 VVEVQETVYVSDVVDSDITVHNYVPDDPDSVVIQDVIEDVVIEDVqcTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHC 112
Cdd:PRK10811   847 VVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAV--AEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPV 924

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807934  113 TVPDDVLASDITSASISMPEHV--LTSESIHVSDVSHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANG 190
Cdd:PRK10811   925 TEQPQVITESDVAVAQEVAEHAepVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPA 1004


                   ....*
gi 1958807934  191 VPVNQ 195
Cdd:PRK10811  1005 QVPEA 1009
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 492-514 1.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|...
gi 1958807934 492 HICVECGKGFRHPSELKKHMRIH 514
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 663-685 1.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|...
gi 1958807934 663 FRCKRCRKGFRQQSELKKHMKTH 685
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 369-391 9.25e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.25e-03
                          10        20
                  ....*....|....*....|...
gi 1958807934 369 YPCMICGKKFKSRGFLKRHMKNH 391
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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