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Conserved domains on  [gi|1958808050|ref|XP_038955919|]
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ankyrin repeat and SOCS box protein 12 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-204 3.43e-26

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 3.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050   5 DIAKIFSLLQPEKEEEDADTGEKQALNQAVYDNDSCTLDHLLHQERYkrfINSRSGWGipGTPLRLAASYGHLDCVKVLL 84
Cdd:COG0666    66 DLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNGNLEIVKLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  85 EHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANVKAKLPV 164
Cdd:COG0666   141 EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958808050 165 WasniascsgPLYLAAVYGHLDCFRLLLLYGADPDYNCID 204
Cdd:COG0666   221 T---------ALDLAAENGNLEIVKLLLEAGADLNAKDKD 251
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 267-306 2.17e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


:

Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.39  E-value: 2.17e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958808050 267 TPRSLLSQARLVIRRSLCRANqPQAIDQLDIPPVLISYLK 306
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-204 3.43e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 3.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050   5 DIAKIFSLLQPEKEEEDADTGEKQALNQAVYDNDSCTLDHLLHQERYkrfINSRSGWGipGTPLRLAASYGHLDCVKVLL 84
Cdd:COG0666    66 DLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNGNLEIVKLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  85 EHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANVKAKLPV 164
Cdd:COG0666   141 EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958808050 165 WasniascsgPLYLAAVYGHLDCFRLLLLYGADPDYNCID 204
Cdd:COG0666   221 T---------ALDLAAENGNLEIVKLLLEAGADLNAKDKD 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-159 6.05e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 6.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  68 LRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEagACPSGSIYNNCSPVLTASRDGAFAILQ 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 1958808050 148 ELLGHGAEANVK 159
Cdd:pfam12796  79 LLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-220 4.42e-14

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 72.59  E-value: 4.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEagaCPSGSIYNNCSPVL-TASRDGAFA 144
Cdd:PLN03192  560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYH---FASISDPHAAGDLLcTAAKRNDLT 636

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958808050 145 ILQELLGHGAEANVKAKLPVWAsniascsgpLYLAAVYGHLDCFRLLLLYGADpdyncIDQALLSRVPQPRTLLEI 220
Cdd:PLN03192  637 AMKELLKQGLNVDSEDHQGATA---------LQVAMAEDHVDMVRLLIMNGAD-----VDKANTDDDFSPTELREL 698
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 267-306 2.17e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.39  E-value: 2.17e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958808050 267 TPRSLLSQARLVIRRSLCRANqPQAIDQLDIPPVLISYLK 306
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 267-308 1.43e-06

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 44.38  E-value: 1.43e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958808050 267 TPRSLLSQARLVIRRSLCRaNQPQAIDQLDIPPVLISYLKHQ 308
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGK-RRLDLIDKLPLPPRLKDYLLYK 41
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 66-91 4.87e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 4.87e-05
                           10        20
                   ....*....|....*....|....*.
gi 1958808050   66 TPLRLAASYGHLDCVKVLLEHGADVD 91
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 269-308 6.83e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 39.31  E-value: 6.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958808050  269 RSLLSQARLVIRRSLcranqpQAIDQLDIPPVLISYLKHQ 308
Cdd:smart00969   1 RSLQHLCRLAIRRSL------GGIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-198 6.57e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  38 DSCTLD--HLLHQERykrfinsrsgwgIPGTPLRLAASYGHLDCVKVLLE-HGADVDSLDVKAQTPLFTAVSHGHLECVR 114
Cdd:cd22192     1 WAQMLDelHLLQQKR------------ISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAV 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 115 ILLEAG------ACPSgSIYNNCSPVLTASRDGAFAILQELLGHGAE-ANVKAKLPVWASNIASC----SGPLYLAAVYG 183
Cdd:cd22192    69 VLMEAApelvnePMTS-DLYQGETALHIAVVNQNLNLVRELIARGADvVSPRATGTFFRPGPKNLiyygEHPLSFAACVG 147

                         170
                  ....*....|....*
gi 1958808050 184 HLDCFRLLLLYGADP 198
Cdd:cd22192   148 NEEIVRLLIEHGADI 162
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-204 3.43e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 3.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050   5 DIAKIFSLLQPEKEEEDADTGEKQALNQAVYDNDSCTLDHLLHQERYkrfINSRSGWGipGTPLRLAASYGHLDCVKVLL 84
Cdd:COG0666    66 DLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDG--ETPLHLAAYNGNLEIVKLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  85 EHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANVKAKLPV 164
Cdd:COG0666   141 EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958808050 165 WasniascsgPLYLAAVYGHLDCFRLLLLYGADPDYNCID 204
Cdd:COG0666   221 T---------ALDLAAENGNLEIVKLLLEAGADLNAKDKD 251
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-208 2.33e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 2.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  55 INSRSGWGIpgTPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPV 134
Cdd:COG0666   146 VNAQDNDGN--TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958808050 135 LTASRDGAFAILQELLGHGAEANVKAKlpvwasniaSCSGPLYLAAVYGHLDCFRLLLLYGADPDYNCIDQALL 208
Cdd:COG0666   224 DLAAENGNLEIVKLLLEAGADLNAKDK---------DGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
66-266 5.43e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.01  E-value: 5.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAI 145
Cdd:COG0666    56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 146 LQELLGHGAEANVKAKlpvwasniaSCSGPLYLAAVYGHLDCFRLLLLYGADPDYncidqallsRVPQPRTLLEICLHHN 225
Cdd:COG0666   136 VKLLLEAGADVNAQDN---------DGNTPLHLAAANGNLEIVKLLLEAGADVNA---------RDNDGETPLHLAAENG 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958808050 226 CePEYIQLLIDFGAniylpslplDPTSQDDKGIKLLLQARA 266
Cdd:COG0666   198 H-LEIVKLLLEAGA---------DVNAKDNDGKTALDLAAE 228
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-159 6.05e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 6.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  68 LRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEagACPSGSIYNNCSPVLTASRDGAFAILQ 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 1958808050 148 ELLGHGAEANVK 159
Cdd:pfam12796  79 LLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-220 4.42e-14

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 72.59  E-value: 4.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEagaCPSGSIYNNCSPVL-TASRDGAFA 144
Cdd:PLN03192  560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYH---FASISDPHAAGDLLcTAAKRNDLT 636

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958808050 145 ILQELLGHGAEANVKAKLPVWAsniascsgpLYLAAVYGHLDCFRLLLLYGADpdyncIDQALLSRVPQPRTLLEI 220
Cdd:PLN03192  637 AMKELLKQGLNVDSEDHQGATA---------LQVAMAEDHVDMVRLLIMNGAD-----VDKANTDDDFSPTELREL 698
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 78-202 2.20e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.91  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  78 DCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEAN 157
Cdd:PHA02874  105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958808050 158 VKAklpvwaSNIAScsgPLYLAAVYGHLDCFRLLLLYGADPDYNC 202
Cdd:PHA02874  185 VKD------NNGES---PLHNAAEYGDYACIKLLIDHGNHIMNKC 220
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-117 1.04e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.13  E-value: 1.04e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILL 117
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 70-214 1.20e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.22  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  70 LAASyGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQEL 149
Cdd:PTZ00322   89 LAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958808050 150 LGHGAEanvkaklpvwASNIASCSGPLYLAAVYGHLDcfrLLLLYGADPDYncidqallSRVPQP 214
Cdd:PTZ00322  168 SRHSQC----------HFELGANAKPDSFTGKPPSLE---DSPISSHHPDF--------SAVPQP 211
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 80-242 2.08e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.22  E-value: 2.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  80 VKVLLEHGADVDSLDVKAQTPLFTAVSH--GHLECVRILLEAGA--CPSGSIYNNCSPVLTASRDGAFAILQELLGHGAE 155
Cdd:PHA03100   89 VKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGAnvNIKNSDGENLLHLYLESNKIDLKILKLLIDKGVD 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 156 ANVKAKL--------PVWASNIASCSgPLYLAAVYGHLDCFRLLLLYGADPDYncidqallsrvpqpRTLLEI-CLHH-- 224
Cdd:PHA03100  169 INAKNRVnyllsygvPINIKDVYGFT-PLHYAVYNNNPEFVKYLLDLGANPNL--------------VNKYGDtPLHIai 233

                         170
                  ....*....|....*....
gi 1958808050 225 -NCEPEYIQLLIDFGANIY 242
Cdd:PHA03100  234 lNNNKEIFKLLLNNGPSIK 252
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 25-197 1.29e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.46  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  25 GEKQALNQAVYDNDSCTLDHLLHQERYKRFINSRSGwgipGTPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTA 104
Cdd:PHA02875   67 DIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDG----MTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLA 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 105 VSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANVKAKLPvwasniasCSGPLYLAAVYGH 184
Cdd:PHA02875  143 VMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG--------CVAALCYAIENNK 214

                         170
                  ....*....|...
gi 1958808050 185 LDCFRLLLLYGAD 197
Cdd:PHA02875  215 IDIVRLFIKRGAD 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 66-231 4.49e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.20  E-value: 4.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGAcpSGSIYNNC--SPV-LTASRDGA 142
Cdd:PHA02878  170 TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA--STDARDKCgnTPLhISVGYCKD 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 143 FAILQELLGHGAEANVKaklpvwaSNIASCSgPLYLAavYGHLDCFRLLLLYGADPD-YNCIDQALLSRVPQPRTLLEIC 221
Cdd:PHA02878  248 YDILKLLLEHGVDVNAK-------SYILGLT-ALHSS--IKSERKLKLLLEYGADINsLNSYKLTPLSSAVKQYLCINIG 317

                         170
                  ....*....|...
gi 1958808050 222 ---LHHNCEPEYI 231
Cdd:PHA02878  318 rilISNICLLKRI 330
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 66-161 7.31e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.51  E-value: 7.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAI 145
Cdd:PHA02874  126 TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                          90
                  ....*....|....*.
gi 1958808050 146 LQELLGHGAEANVKAK 161
Cdd:PHA02874  206 IKLLIDHGNHIMNKCK 221
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-240 1.08e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 52.69  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGA--DVDSLDVKaqTPLFTAVSHGHLECVRILLEAGACPSGSIYNN-CSPVLTASRDGA 142
Cdd:PHA02875   37 SPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIE--SELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKK 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 143 FAILQELLGHGAEANVKAK-------LPVWA---------------SNIASCSG--PLYLAAVYGHLDCFRLLLLYGADP 198
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTdkfsplhLAVMMgdikgiellidhkacLDIEDCCGctPLIIAMAKGDIAICKMLLDSGANI 194

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958808050 199 DYncidqalLSRVPQPrTLLEICLHHNcEPEYIQLLIDFGAN 240
Cdd:PHA02875  195 DY-------FGKNGCV-AALCYAIENN-KIDIVRLFIKRGAD 227
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-158 1.80e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVL-TASRDGAFA 144
Cdd:PHA02875  137 SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKID 216

                          90
                  ....*....|....
gi 1958808050 145 ILQELLGHGAEANV 158
Cdd:PHA02875  217 IVRLFIKRGADCNI 230
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 267-306 2.17e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.39  E-value: 2.17e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958808050 267 TPRSLLSQARLVIRRSLCRANqPQAIDQLDIPPVLISYLK 306
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRR-LGAIDKLPLPPLLKDYLL 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 66-124 5.92e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 5.92e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPS 124
Cdd:PTZ00322  117 TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHF 175
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 66-241 8.03e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.45  E-value: 8.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  66 TPLRLAASYGHLD-CVKVLLEHGADVDSLDVKAQTPLFTAVSHGH-LECVRILLEAGA--CPSGSIYNncSPVLTASR-D 140
Cdd:PHA02876  275 TPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGAdvNAADRLYI--TPLHQASTlD 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 141 GAFAILQELLGHGAEANVKAKLPvwasniascSGPLYLAAVYGHLDCFRLLLLYGADPD-------------------YN 201
Cdd:PHA02876  353 RNKDIVITLLELGANVNARDYCD---------KTPIHYAAVRNNVVIINTLLDYGADIEalsqkigtalhfalcgtnpYM 423

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958808050 202 CIdQALLSR---VPQPRTLLEICLHH----NCEPEYIQLLIDFGANI 241
Cdd:PHA02876  424 SV-KTLIDRganVNSKNKDLSTPLHYackkNCKLDVIEMLLDNGADV 469
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 267-308 1.43e-06

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 44.38  E-value: 1.43e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958808050 267 TPRSLLSQARLVIRRSLCRaNQPQAIDQLDIPPVLISYLKHQ 308
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGK-RRLDLIDKLPLPPRLKDYLLYK 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 80-158 2.74e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 2.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958808050  80 VKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANV 158
Cdd:PHA03100  175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 98-205 2.82e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  98 QTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANVKA----------------- 160
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpdieselhdaveegdvk 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958808050 161 ------KLPVWASNIASCSG--PLYLAAVYGHLDCFRLLLLYGADPDYNCIDQ 205
Cdd:PHA02875   83 aveellDLGKFADDVFYKDGmtPLHLATILKKLDIMKLLIARGADPDIPNTDK 135
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 66-139 3.81e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 47.67  E-value: 3.81e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQ-TPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASR 139
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 266-308 9.55e-06

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 42.10  E-value: 9.55e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958808050 266 ATPRSLLSQARLVIRRSLCRaNQPQAIDQLDIPPVLISYLKHQ 308
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGR-RRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-94 9.90e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 9.90e-06
                          10        20
                  ....*....|....*....|....*....
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLD 94
Cdd:pfam12796  63 TALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
99-150 2.38e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 2.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958808050  99 TPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELL 150
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 66-94 3.44e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 3.44e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958808050  66 TPLRLAA-SYGHLDCVKVLLEHGADVDSLD 94
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 80-268 4.23e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 4.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  80 VKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSP---------VLTASRDgafaILQELL 150
Cdd:PHA03100   18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPlhylsnikyNLTDVKE----IVKLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 151 GHGAEANVKaklpvwasNIASCSgPLYLAAVY--GHLDCFRLLLLYGADPD------YNCIDQALLSrvpqPRTLLEIcl 222
Cdd:PHA03100   94 EYGANVNAP--------DNNGIT-PLLYAISKksNSYSIVEYLLDNGANVNiknsdgENLLHLYLES----NKIDLKI-- 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958808050 223 hhncepeyIQLLIDFGANI-------YLPSLPLDPTSQDDKG---------------IKLLLQARATP 268
Cdd:PHA03100  159 --------LKLLIDKGVDInaknrvnYLLSYGVPINIKDVYGftplhyavynnnpefVKYLLDLGANP 218
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 66-91 4.87e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 4.87e-05
                           10        20
                   ....*....|....*....|....*.
gi 1958808050   66 TPLRLAASYGHLDCVKVLLEHGADVD 91
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 65-133 6.31e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 6.31e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  65 GTPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGA-CPSGSIYNNCSP 133
Cdd:PLN03192  623 GDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAdVDKANTDDDFSP 692
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 269-308 6.83e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 39.31  E-value: 6.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958808050  269 RSLLSQARLVIRRSLcranqpQAIDQLDIPPVLISYLKHQ 308
Cdd:smart00969   1 RSLQHLCRLAIRRSL------GGIDKLPLPPRLKDYLLYY 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 23-137 1.25e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  23 DTGEKQALNQAVYDNDSCTLDHLLhqeRYKRFINSRSGWGipGTPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLF 102
Cdd:PHA02874  121 DAELKTFLHYAIKKGDLESIKMLF---EYGADVNIEDDNG--CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958808050 103 TAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTA 137
Cdd:PHA02874  196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 66-121 1.43e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.12  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGA 121
Cdd:PHA03100  194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_5 pfam13857
Ankyrin repeats (many copies);
66-101 4.41e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 4.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPL 101
Cdd:pfam13857  18 TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-198 6.57e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  38 DSCTLD--HLLHQERykrfinsrsgwgIPGTPLRLAASYGHLDCVKVLLE-HGADVDSLDVKAQTPLFTAVSHGHLECVR 114
Cdd:cd22192     1 WAQMLDelHLLQQKR------------ISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAV 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 115 ILLEAG------ACPSgSIYNNCSPVLTASRDGAFAILQELLGHGAE-ANVKAKLPVWASNIASC----SGPLYLAAVYG 183
Cdd:cd22192    69 VLMEAApelvnePMTS-DLYQGETALHIAVVNQNLNLVRELIARGADvVSPRATGTFFRPGPKNLiyygEHPLSFAACVG 147

                         170
                  ....*....|....*
gi 1958808050 184 HLDCFRLLLLYGADP 198
Cdd:cd22192   148 NEEIVRLLIEHGADI 162
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 80-241 7.43e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 7.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  80 VKVLLEHGADVDSLDV-KAQTPLFTAVSHGHLECVRILLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANV 158
Cdd:PHA02878  150 TKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 159 KAKlpvwasniasC-SGPLYLAAVY-GHLDCFRLLLLYGADPDyncIDQALLSRVPqprtlLEICLHhncEPEYIQLLID 236
Cdd:PHA02878  230 RDK----------CgNTPLHISVGYcKDYDILKLLLEHGVDVN---AKSYILGLTA-----LHSSIK---SERKLKLLLE 288


                  ....*
gi 1958808050 237 FGANI 241
Cdd:PHA02878  289 YGADI 293
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 66-91 7.48e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958808050  66 TPLRLAASYGHLDCVKVLLEHGADVD 91
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
83-121 9.05e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 9.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958808050  83 LLEHG-ADVDSLDVKAQTPLFTAVSHGHLECVRILLEAGA 121
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV 40
PHA03095 PHA03095
ankyrin-like protein; Provisional
 55-155 1.22e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  55 INSRSGWGIpgTPLRLAASYGH-LDCVKVLLEHGADVDSLDVKAQTPLftavsHGHL-------ECVRILLEAGACPSGS 126
Cdd:PHA03095   76 VNAPERCGF--TPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPL-----HVYLsgfninpKVIRLLLRKGADVNAL 148

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958808050 127 IYNNCSP--VLTASRDGAFAILQELLGHGAE 155
Cdd:PHA03095  149 DLYGMTPlaVLLKSRNANVELLRLLIDAGAD 179
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 99-121 1.53e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.53e-03
                           10        20
                   ....*....|....*....|...
gi 1958808050   99 TPLFTAVSHGHLECVRILLEAGA 121
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGA 26
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 268-308 1.76e-03

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 35.61  E-value: 1.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958808050 268 PRSLLSQARLVIRRSLCRaNQPQAIDQLDIPPVLISYLKHQ 308
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGI-NRIKLIDTLPLPPRLIRYLNHQ 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 70-242 2.31e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.24  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  70 LAASYGHLDCVKVLLEHGADVDSLDVKAQTPLFTAVSHGHLEC---VRILLEAGACPSGSIYNNCSPV-LTASRDGAFAI 145
Cdd:PHA03095   20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050 146 LQELLGHGAEANVKAKLpvwASNIAScsgpLYLAAVYGHLDCFRLLLLYGADP------DYNCIDqALLSRvpqprtlle 219
Cdd:PHA03095  100 IKLLIKAGADVNAKDKV---GRTPLH----VYLSGFNINPKVIRLLLRKGADVnaldlyGMTPLA-VLLKS--------- 162

                         170       180
                  ....*....|....*....|...
gi 1958808050 220 iclhHNCEPEYIQLLIDFGANIY 242
Cdd:PHA03095  163 ----RNANVELLRLLIDAGADVY 181
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 175-200 2.43e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 2.43e-03
                           10        20
                   ....*....|....*....|....*.
gi 1958808050  175 PLYLAAVYGHLDCFRLLLLYGADPDY 200
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 67-162 3.07e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 38.88  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  67 PLRLAASYGHLDCVKVLLEHGADVDSLDVKAQTPLF--TAVSHGHLECVRILLEAGACPSGSI-YNNCSPVLtASRDGAF 143
Cdd:PHA02946   75 PLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYylSGTDDEVIERINLLVQYGAKINNSVdEEGCGPLL-ACTDPSE 153

                          90
                  ....*....|....*....
gi 1958808050 144 AILQELLGHGAEANVKAKL 162
Cdd:PHA02946  154 RVFKKIMSIGFEARIVDKF 172
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 66-121 3.15e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.28  E-value: 3.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958808050  66 TPLRLAASYG-HLDCVKVLLEHGADVDSLDVKAQTPLFTAVshGHLECVRILLEAGA 121
Cdd:PHA02876  444 TPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA 498
PHA03095 PHA03095
ankyrin-like protein; Provisional
 76-199 4.86e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 4.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958808050  76 HLDCVKVLLEHGADVDSLDVKAQTPLFTAV-SHG-HLECVRILLEAGACPSGSIYNNCSPV---LTASRDGAfAILQELL 150
Cdd:PHA03095  131 NPKVIRLLLRKGADVNALDLYGMTPLAVLLkSRNaNVELLRLLIDAGADVYAVDDRFRSLLhhhLQSFKPRA-RIVRELI 209

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958808050 151 GHG---AEANVKAKLPV-WASNIASCSG----------------------PLYLAAVYGHLDCFRLLLLYGADPD 199
Cdd:PHA03095  210 RAGcdpAATDMLGNTPLhSMATGSSCKRslvlplliagisinarnrygqtPLHYAAVFNNPRACRRLIALGADIN 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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