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Conserved domains on  [gi|1958653119|ref|XP_038956825|]
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zinc finger protein ZFP2 isoform X3 [Rattus norvegicus]

Protein Classification

KRAB_A-box and COG5048 domain-containing protein( domain architecture ID 12017141)

protein containing domains KRAB_A-box, COG5048, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-66 2.25e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.25e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958653119  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSV 66
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-758 3.45e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 356 TPFICDICGKAFLRKSELTSHKQSHSGEKPYKCND--CGKSFKFPSQLKVHRQIHTGEKPYECR-ECGKSFSKTAKLKVH 432
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 433 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 505
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 506 SFNFPCELKVHYQNHTGEKPYKcrecwKLFSKMSQLKAHYRVhtgerPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 585
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-----IPSSSSDQNLENSSS-----SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 586 ECGKAFSSRSSFRKHQLIHT-------KEKPFVSQKCETGL-QESTLTPHQQ--LHIGE--KPYKCP--DCGKLFNYPSQ 651
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFsRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 652 LKSHYQIHTGEKPCKCPDCGKSFSKTSQLKA-------HSRIHTGERPYVCSV--CGKAFKQLSTLSRHEKIHMVEKPYK 722
Cdd:COG5048   339 LKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1958653119 723 CNF--CGKSFCSPSELKVHLLIHTGERPYkCNSCWKAF 758
Cdd:COG5048   419 CKNppCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSF 455
zf-H2C2_2 pfam13465
Zinc-finger double domain;
764-788 5.16e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*
gi 1958653119 764 LQEHERIHTGERPYVCTHCGKAFRS 788
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 3.61e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.61e-03
                          10        20
                  ....*....|....*....|....*
gi 1958653119 316 ALQQHEQIHTEEKPYVCTLCGKAFS 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-66 2.25e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.25e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958653119  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSV 66
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
27-67 6.95e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.10  E-value: 6.95e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958653119   27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSVE 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 1.67e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.67e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958653119  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLS 65
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-758 3.45e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 356 TPFICDICGKAFLRKSELTSHKQSHSGEKPYKCND--CGKSFKFPSQLKVHRQIHTGEKPYECR-ECGKSFSKTAKLKVH 432
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 433 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 505
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 506 SFNFPCELKVHYQNHTGEKPYKcrecwKLFSKMSQLKAHYRVhtgerPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 585
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-----IPSSSSDQNLENSSS-----SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 586 ECGKAFSSRSSFRKHQLIHT-------KEKPFVSQKCETGL-QESTLTPHQQ--LHIGE--KPYKCP--DCGKLFNYPSQ 651
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFsRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 652 LKSHYQIHTGEKPCKCPDCGKSFSKTSQLKA-------HSRIHTGERPYVCSV--CGKAFKQLSTLSRHEKIHMVEKPYK 722
Cdd:COG5048   339 LKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1958653119 723 CNF--CGKSFCSPSELKVHLLIHTGERPYkCNSCWKAF 758
Cdd:COG5048   419 CKNppCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSF 455
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-453 2.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.20e-04
                          10        20
                  ....*....|....*....|....*
gi 1958653119 429 LKVHQRIHTGEKPYVCSQCGKAFNQ 453
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
764-788 5.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*
gi 1958653119 764 LQEHERIHTGERPYVCTHCGKAFRS 788
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 3.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.61e-03
                          10        20
                  ....*....|....*....|....*
gi 1958653119 316 ALQQHEQIHTEEKPYVCTLCGKAFS 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-66 2.25e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.25e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958653119  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSV 66
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
27-67 6.95e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.10  E-value: 6.95e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958653119   27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSVE 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 1.67e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.67e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958653119  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLS 65
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-758 3.45e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 356 TPFICDICGKAFLRKSELTSHKQSHSGEKPYKCND--CGKSFKFPSQLKVHRQIHTGEKPYECR-ECGKSFSKTAKLKVH 432
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 433 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 505
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 506 SFNFPCELKVHYQNHTGEKPYKcrecwKLFSKMSQLKAHYRVhtgerPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 585
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-----IPSSSSDQNLENSSS-----SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 586 ECGKAFSSRSSFRKHQLIHT-------KEKPFVSQKCETGL-QESTLTPHQQ--LHIGE--KPYKCP--DCGKLFNYPSQ 651
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFsRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 652 LKSHYQIHTGEKPCKCPDCGKSFSKTSQLKA-------HSRIHTGERPYVCSV--CGKAFKQLSTLSRHEKIHMVEKPYK 722
Cdd:COG5048   339 LKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1958653119 723 CNF--CGKSFCSPSELKVHLLIHTGERPYkCNSCWKAF 758
Cdd:COG5048   419 CKNppCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-712 3.36e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 300 DPYKCSSCEESFCTEAALQQHEQIHTEEKPYVCTL--CGKAFSDGSAFYEHELIHKNHTPFICDICGKafLRKSELTSHK 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 378 QSHSGEKPYKCNDCgkSFKFPSQLKVHRQIHTGEKPYECRECG--KSFSKTAKLKVHQRIHtGEKPYVCSQCGKAFNQKS 455
Cdd:COG5048   110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPlpGNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 456 ILdrHEKLHPGEKPYKCSDCGKSFNYPSQLKVHCHSHTGEKPYKCHECgkSFNFPCELKVHYQNHTGEKPYKCRECWKLF 535
Cdd:COG5048   187 LI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 536 S----KMSQLKAHYRVHTGER-----PYKCSHCGKAFSTKEQVQEHER--IHTGE--KPFVCTE--CGKAFSSRSSFRKH 600
Cdd:COG5048   263 SslptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 601 QLIHTKEKPF---------VSQKCETGLQESTLTPHQQLHIgEKPYKCPDCGKLFNYPSQ--LKSHYQIHTGEKP--CKC 667
Cdd:COG5048   343 ILLHTSISPAkekllnsssKFSPLLNNEPPQSLQQYKDLKN-DKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPynCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1958653119 668 PDCGKSFSKTSQLKAHSRIHTGERPYVCSVCGKAFKQLSTLSRHE 712
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
552-832 2.23e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 552 RPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT--ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCetGLQESTLTPHQQ 629
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKS--LPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 630 L----HIGEKPYKCPDCGKLFNYPSQLKSHYQIHTGEKPCKCPDCGKSFSKTSQ----------------------LKAH 683
Cdd:COG5048   110 LssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 684 SRIHTGERPYVCSVCGKAFKQLSTLSRHEKIHMVEKPYKCNFCG----------------------------------KS 729
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssasesprsslptAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 730 FCSPSELKVHLLIHTGER-PYKCNSCWKAFCTKVQLQEHER--IHTGE--RPYVCTH--CGKAFRSRSVFSKHKLIHRKV 802
Cdd:COG5048   270 SQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1958653119 803 TPFIC--ERCGKVFLQKSELTSHLQTHIEDKP 832
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQQYKDL 381
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 632-713 1.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 632 IGEKPYKCP--DCGKLFNYPSQLKSH-YQIHTGEKPCKCPDCGKsfsktsqlkaHSRIHTGERPYVCSVCGKAFKQLSTL 708
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*
gi 1958653119 709 SRHEK 713
Cdd:COG5189   415 KYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-453 2.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.20e-04
                          10        20
                  ....*....|....*....|....*
gi 1958653119 429 LKVHQRIHTGEKPYVCSQCGKAFNQ 453
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
708-730 4.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.86e-04
                          10        20
                  ....*....|....*....|...
gi 1958653119 708 LSRHEKIHMVEKPYKCNFCGKSF 730
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
764-788 5.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*
gi 1958653119 764 LQEHERIHTGERPYVCTHCGKAFRS 788
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
680-704 7.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.06e-04
                          10        20
                  ....*....|....*....|....*
gi 1958653119 680 LKAHSRIHTGERPYVCSVCGKAFKQ 704
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
570-593 7.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.13e-04
                          10        20
                  ....*....|....*....|....
gi 1958653119 570 QEHERIHTGEKPFVCTECGKAFSS 593
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-481 7.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1958653119 457 LDRHEKLHPGEKPYKCSDCGKSFNY 481
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-508 9.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.48e-04
                          10        20
                  ....*....|....*....|....
gi 1958653119 485 LKVHCHSHTGEKPYKCHECGKSFN 508
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-425 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1958653119 401 LKVHRQIHTGEKPYECRECGKSFSK 425
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-565 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1958653119 541 LKAHYRVHTGERPYKCSHCGKAFST 565
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
372-396 1.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.79e-03
                          10        20
                  ....*....|....*....|....*
gi 1958653119 372 ELTSHKQSHSGEKPYKCNDCGKSFK 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 405-492 2.26e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 405 RQIHTGEKPYECR--ECGKSFSKTAKLKVHqRIHtgekpyvcSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKSFNYP 482
Cdd:COG5189   341 MLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNL 411

                          90
                  ....*....|.
gi 1958653119 483 SQLKVH-CHSH 492
Cdd:COG5189   412 NGLKYHrKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 3.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.61e-03
                          10        20
                  ....*....|....*....|....*
gi 1958653119 316 ALQQHEQIHTEEKPYVCTLCGKAFS 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 386-408 3.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|...
gi 1958653119 386 YKCNDCGKSFKFPSQLKVHRQIH 408
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 662-739 4.96e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958653119 662 EKPCKCPDCGKSFSKTSQLKAH---SRIHT-GERPYVCSV--CGKAFKQLSTLSRHEK-------------------IHM 716
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSA 394

                          90       100
                  ....*....|....*....|...
gi 1958653119 717 VEKPYKCNFCGKSFCSPSELKVH 739
Cdd:COG5189   395 KDKPYRCEVCDKRYKNLNGLKYH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 721-743 8.59e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.59e-03
                          10        20
                  ....*....|....*....|...
gi 1958653119 721 YKCNFCGKSFCSPSELKVHLLIH 743
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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