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Conserved domains on  [gi|1958749301|ref|XP_038957728|]
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tissue factor isoform X3 [Rattus norvegicus]

Protein Classification

Tissue_fac and Interfer-bind domain-containing protein( domain architecture ID 10471435)

Tissue_fac and Interfer-bind domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 118-225 2.27e-26

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 99.34  E-value: 2.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749301 118 TKIGQPVIQKyEQDGTKLKVTVKDSFTlvrKNGTFLTLRQVFGnDLGYILTYRKDSSTGRKTNTTHTNEF--LIDVEKGV 195
Cdd:pfam09294   1 TIIGPPEVEL-EVEGGSLNVTVKDPET---REGKNLSLRDLYG-SLQYRVSYWKNSSNGEKKNTTSTNSFvvLSDLEPGT 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958749301 196 SYCFFVQAviFSRKTNHKSPESITKCTEQW 225
Cdd:pfam09294  76 TYCVSVQA--FSPLDNKSSQRSPPQCIRTT 103
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 1-90 1.73e-22

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 88.98  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749301   1 MGHPLFFTSTPPGKAFNLTWISTDFKTILEWQP---KPTNYTYTVQIS-DRSRNWK--YKCTGTTDTECDLTDEIVkDVN 74
Cdd:pfam01108  11 LALASAAGGPSLPAPQNVTFQSTNFKNILTWEPgpnSPPDVVYTVQYKiYGSGDWKnvPNCTNITRTECDLTDETS-DLT 89

                          90
                  ....*....|....*.
gi 1958749301  75 WTYEARVLSVpWRNST 90
Cdd:pfam01108  90 ETYYARVRAV-SGGGT 104
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 118-225 2.27e-26

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 99.34  E-value: 2.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749301 118 TKIGQPVIQKyEQDGTKLKVTVKDSFTlvrKNGTFLTLRQVFGnDLGYILTYRKDSSTGRKTNTTHTNEF--LIDVEKGV 195
Cdd:pfam09294   1 TIIGPPEVEL-EVEGGSLNVTVKDPET---REGKNLSLRDLYG-SLQYRVSYWKNSSNGEKKNTTSTNSFvvLSDLEPGT 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958749301 196 SYCFFVQAviFSRKTNHKSPESITKCTEQW 225
Cdd:pfam09294  76 TYCVSVQA--FSPLDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 1-90 1.73e-22

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 88.98  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749301   1 MGHPLFFTSTPPGKAFNLTWISTDFKTILEWQP---KPTNYTYTVQIS-DRSRNWK--YKCTGTTDTECDLTDEIVkDVN 74
Cdd:pfam01108  11 LALASAAGGPSLPAPQNVTFQSTNFKNILTWEPgpnSPPDVVYTVQYKiYGSGDWKnvPNCTNITRTECDLTDETS-DLT 89

                          90
                  ....*....|....*.
gi 1958749301  75 WTYEARVLSVpWRNST 90
Cdd:pfam01108  90 ETYYARVRAV-SGGGT 104
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 118-225 2.27e-26

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 99.34  E-value: 2.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749301 118 TKIGQPVIQKyEQDGTKLKVTVKDSFTlvrKNGTFLTLRQVFGnDLGYILTYRKDSSTGRKTNTTHTNEF--LIDVEKGV 195
Cdd:pfam09294   1 TIIGPPEVEL-EVEGGSLNVTVKDPET---REGKNLSLRDLYG-SLQYRVSYWKNSSNGEKKNTTSTNSFvvLSDLEPGT 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958749301 196 SYCFFVQAviFSRKTNHKSPESITKCTEQW 225
Cdd:pfam09294  76 TYCVSVQA--FSPLDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 1-90 1.73e-22

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 88.98  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749301   1 MGHPLFFTSTPPGKAFNLTWISTDFKTILEWQP---KPTNYTYTVQIS-DRSRNWK--YKCTGTTDTECDLTDEIVkDVN 74
Cdd:pfam01108  11 LALASAAGGPSLPAPQNVTFQSTNFKNILTWEPgpnSPPDVVYTVQYKiYGSGDWKnvPNCTNITRTECDLTDETS-DLT 89

                          90
                  ....*....|....*.
gi 1958749301  75 WTYEARVLSVpWRNST 90
Cdd:pfam01108  90 ETYYARVRAV-SGGGT 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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