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Conserved domains on  [gi|1958768273|ref|XP_038963032|]
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alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2 [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 2-196 2.48e-149

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23989:

Pssm-ID: 480271  Cd Length: 272  Bit Score: 415.38  E-value: 2.48e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGT 81
Cdd:cd23989    78 SGCGQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 EPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPISH 161
Cdd:cd23989   158 DPSLRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISH 237

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958768273 162 HYYDNVLPFSGFHAMPEEFLQLWYLHKMGALRMQL 196
Cdd:cd23989   238 HYYDNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 2-196 2.48e-149

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 415.38  E-value: 2.48e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGT 81
Cdd:cd23989    78 SGCGQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 EPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPISH 161
Cdd:cd23989   158 DPSLRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISH 237

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958768273 162 HYYDNVLPFSGFHAMPEEFLQLWYLHKMGALRMQL 196
Cdd:cd23989   238 HYYDNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 2-191 4.64e-79

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 236.73  E-value: 4.64e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFS 76
Cdd:pfam00777  58 SGCGKEIDSHDFVIRCNLAPTK-GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  77 MKTGTEPSLRVYYTLKDAGANQT---VLFANPNFLRNIGKFW-KGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsv 152
Cdd:pfam00777 137 TKGNVSRSLRVLYTLKEVKIPVDpdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF-- 214

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958768273 153 nMQGEPISHHYYDNVLP----FSGFHAMPEEFLQLWYLHKMGA 191
Cdd:pfam00777 215 -LDSRGNSHHYYDNVLMkkggFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 2-196 2.48e-149

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 415.38  E-value: 2.48e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGT 81
Cdd:cd23989    78 SGCGQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 EPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPISH 161
Cdd:cd23989   158 DPSLRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISH 237

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958768273 162 HYYDNVLPFSGFHAMPEEFLQLWYLHKMGALRMQL 196
Cdd:cd23989   238 HYYDNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 2-196 2.94e-128

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 361.96  E-value: 2.94e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSseYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGT 81
Cdd:cd23971    79 SSCGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNT 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 EPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPISH 161
Cdd:cd23971   157 EPSLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISH 236

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958768273 162 HYYDNVLPFSGFHAMPEEFLQLWYLHKMGALRMQL 196
Cdd:cd23971   237 HYYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 2-196 2.16e-91

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 268.93  E-value: 2.16e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGT 81
Cdd:cd23991    79 SSCGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNT 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 EPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPISH 161
Cdd:cd23991   159 ALSFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISH 238

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958768273 162 HYYDNVLPFSGFHAMPEEFLQLWYLHKMGALRMQL 196
Cdd:cd23991   239 HYYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 2-196 1.04e-85

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 254.49  E-value: 1.04e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKT 79
Cdd:cd23963    78 SGCGKEIDSHDFVIRCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKS 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  80 GTEPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIhAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPI 159
Cdd:cd23963   157 STNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPV 235

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958768273 160 SHHYYDNVLP--FSGFHAMPEEFLQLWYLHKMGALRMQL 196
Cdd:cd23963   236 PYHYYDDLSPstKNKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 2-191 4.64e-79

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 236.73  E-value: 4.64e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFS 76
Cdd:pfam00777  58 SGCGKEIDSHDFVIRCNLAPTK-GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  77 MKTGTEPSLRVYYTLKDAGANQT---VLFANPNFLRNIGKFW-KGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsv 152
Cdd:pfam00777 137 TKGNVSRSLRVLYTLKEVKIPVDpdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF-- 214

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958768273 153 nMQGEPISHHYYDNVLP----FSGFHAMPEEFLQLWYLHKMGA 191
Cdd:pfam00777 215 -LDSRGNSHHYYDNVLMkkggFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 2-194 2.15e-76

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 230.88  E-value: 2.15e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGT 81
Cdd:cd23990    79 SKCGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNT 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 EPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPISH 161
Cdd:cd23990   159 DVSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITH 238

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958768273 162 HYYDNVLPFSGFHAMPEEFLQLWYLHKMGALRM 194
Cdd:cd23990   239 HYYDNVKPRPGFHAMPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 2-195 2.08e-55

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 177.22  E-value: 2.08e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLLWS--RKKFVDNMKIYNHSYIYMPAFSMKT 79
Cdd:cd23969    79 SGCGQEIDSHDFVIRCNLAPVE-GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFVSKG 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  80 GTEpslRVYYTL---KDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQG 156
Cdd:cd23969   158 GEE---HVQWTNeiiLKHKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNG 234

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958768273 157 EPISHHYYDNvLPFS---GFHAMPEEFLQLWYLHKMGALRMQ 195
Cdd:cd23969   235 RAVKYHYYDN-RKYLttaRPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 2-196 1.08e-54

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 175.66  E-value: 1.08e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKT 79
Cdd:cd23970    83 SQCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFHT 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  80 GTePSLR--VYYTLKDAGaNQTVLFANP-NFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQG 156
Cdd:cd23970   162 SA-TVTRtlVDFFVEHRG-QLKVQLAWPgNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTG 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958768273 157 EPISHHYYDN-----VLPFSGFHAMPEEFLQLWYLHKMGALRMQL 196
Cdd:cd23970   240 TPLPYHYYDKkgtkfTTKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 2-194 1.04e-48

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 160.10  E-value: 1.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL---WsRKKFVDNMKIYNHSYIYMPAFSMK 78
Cdd:cd23987    79 SGCGREIDSHDFVIRCNLAPVE-EYAKDVGTKTDLVTMNPSVVQRAFEDLVnetW-KEKFLQRLQSLNGSILWIPAFMAK 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  79 TGTEPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEP 158
Cdd:cd23987   157 GGEERVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNP 236

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958768273 159 ISHHYYDNV----LPFSGFHAMPEEFLQLWYLHKMGALRM 194
Cdd:cd23987   237 VKYHYYDSLkygyTSQASPHTMPLEFKALKNLHQQGALKL 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 2-194 9.57e-44

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 147.41  E-value: 9.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKT 79
Cdd:cd23988    79 SGCGKEIDSHDFVIRCNLAPVV-EFAADVGTKSDFITMNPSVVQRAFGGFRneSDREKFVHRLSMLNDSVLWIPAFMVKG 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  80 GTEPSLRV-YYTLKDAGANQTVlFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEP 158
Cdd:cd23988   158 GEKHVEWVnALILKNKLKVRTA-YPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNP 236

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958768273 159 ISHHYYDNV----LPFSGFHAMPEEFLQLWYLHKMGALRM 194
Cdd:cd23988   237 VKYHYYDDLkyryFSNAGPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 2-172 1.50e-18

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 79.71  E-value: 1.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYnhsYIYMPAFsmktgT 81
Cdd:cd19952    13 SEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPLEEEVV---LILSRAA-----A 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 EPSLRVYYTLKDAGANQT-VLFANPNF-------LRNIGKFWKGRGIHAkrlSTGLFLVSAALGLCEEVSIYGFWPFSVN 153
Cdd:cd19952    84 ADFKRLKRRKKRHDNAVLlLTDPAPDLlsyvrkrLEKLGLKSFFGGNAP---SSGLLAVLLALQLCDSVDLYGFGVDSGH 160

                         170
                  ....*....|....*....
gi 1958768273 154 MQGEPisHHYYDNVLPFSG 172
Cdd:cd19952   161 APKVP--YHYYDLVEAEEG 177
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 2-193 2.07e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 72.68  E-value: 2.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPpLSSEYTRDVGSKTQLVTANP--SIIRQRFENLLWSRKKFVDNM-KIYnhSYIYMPAFS-- 76
Cdd:cd23964    97 SGKGKEIDAHDYVFRVNHA-LTKGFEKDVGTKTSFYTFFPesLHNSLLKHVPQDKDTKYLFIPfKIR--DYDYLDAVLsg 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  77 --MKTGTEPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFW-KGRGIHakRLSTGLFLVSAALGLCEEVSIYGF---WPF 150
Cdd:cd23964   174 kpVPDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWlNSSTSY--RPTTGALMLLTALHTCDQVSVYGFgydPRF 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958768273 151 SVnmqgepishHYYDN----VLPFSGFHAMPEEfLQLW-YLHKMGALR 193
Cdd:cd23964   252 SL---------HYYDKtfvkFTVFYANHDFTNE-RKLWrKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 2-194 7.56e-10

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 56.91  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPsiirQRFENLLWSRKKFVDNMKIYNHSYIyMPAFSMKTGT 81
Cdd:cd23966    92 SRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTTHHFMYP----ESAVDLDPGVHLVLVPFKVLDLQWL-ISALTTGEIT 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  82 epslRVYYTLKDA-GANQT-VLFANPNFLRNIGKFWKGRgiHAKRLSTGLFLVSAALGLCEEVSIYGF-------Wpfsv 152
Cdd:cd23966   166 ----RTYTPVKRFiKADKDkVLVINPAFIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFGFgadskgnW---- 235

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958768273 153 nmqgepisHHYYDNVLPFSGF-----HAMPEEFLQLWYLHKMGALRM 194
Cdd:cd23966   236 --------HHYWEKNRSAGAFrktgvHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 2-169 2.45e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 55.26  E-value: 2.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQL-VTANPS---IIRQRFENLLWSRKKFV------DNMK------IY 65
Cdd:cd23976    30 SNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSiqrILRNRNELLNVSQGTVFifwgpsNYMRrdgkglVY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  66 NHsyiympaFSMKTGTEPSLRVYYTLKdaganQTVLFANPNFLRNIGKfwkGRGIHAKRLSTGLFLVSAALGLCEEVSIY 145
Cdd:cd23976   109 NN-------LQLMNQILPKLKVYTITR-----HKMLQFDELFKRETGK---DRKISNTWLSTGWFTMIIALELCDRINVY 173

                         170       180
                  ....*....|....*....|....*.
gi 1958768273 146 GFWP--FSVNMQGEPISHHYYDNVLP 169
Cdd:cd23976   174 GMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 5-166 1.26e-08

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 53.73  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   5 GRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFEN--LLWSRKKFVDNMKIY--------NHSYIYMPA 74
Cdd:cd23980    99 GPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNvsMILVPFKTLDLEWVIsatttgtiSHTYVPVPR 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  75 fsmktgtepSLRVyytlkdagANQTVLFANPNFLRNIGKFWKGRgiHAKRLSTGLFLVSAALGLCEEVSIYGfwpFSVNM 154
Cdd:cd23980   178 ---------KIKV--------KKEKILIYHPAFIKYVFDRWLQG--HGRYPSTGILSVIFSLHVCDEVDLYG---FGADS 235

                         170
                  ....*....|..
gi 1958768273 155 QGEpiSHHYYDN 166
Cdd:cd23980   236 KGN--WHHYWEN 245
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 5-165 2.31e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 52.55  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   5 GRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRqrfenLLWSRKKFVDnmKIYNHSYIYM-PAFSMKTGTE 82
Cdd:cd23978    19 GPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSVYR-----VLRRPQEFLN--RTPETTLIFWgPPNKMQKDGK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  83 PSL-RVYYTLKDAGANQTVLFANPNFLRNIGKFWKG-----RGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPF---SVN 153
Cdd:cd23978    91 SNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGetgrdRKKSHSWLSTGWFTMVIAVELCDNVHVYGMVPPnycSKR 170

                         170
                  ....*....|..
gi 1958768273 154 MQGEPISHHYYD 165
Cdd:cd23978   171 PTPKKMPYHYYE 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 2-165 4.63e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 51.40  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLV----TANPSIIRQR---FEN------LLWSRKKFVDNMKiynhS 68
Cdd:cd23977    16 SGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRvvshTSVPLLLRNQgyfFQQsrdtkyVIWGPERNMDRDG----G 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  69 YIYMPAFSMKTGTEPSLRVYYTLKDAGANQTVLFANPNflrnigkfWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFW 148
Cdd:cd23977    91 GKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNET--------GKNRMKSGSFLSTGWFTMILALELCEEILVYGMV 162

                         170
                  ....*....|....*....
gi 1958768273 149 PFSV--NMQGEPISHHYYD 165
Cdd:cd23977   163 SDSYcrNKNHSSVPYHYYE 181
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 2-194 7.82e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 51.29  E-value: 7.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFEN-----------LLWSRKKFVDNmkiYNHSYI 70
Cdd:cd23974    99 SRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngppqSKETRYIFLPD---HDRDYL 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  71 YMPAFSMKT----GTEPSLR-VYYTLKDAGANQTVLFaNPNFLRNI-GKFWKGRGIHAK-----RLSTGLFLVSAALGLC 139
Cdd:cd23974   175 LVKAALTHTpidrGRDKSKRpSKYFGKDVTAEKFKIY-HPDFIRYLrNRFLWSPILNTKqrdiyRPSTGAVMLLAALHTC 253

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768273 140 EEVSIYGFWPFSVNMqgepISHHYYDNVLPFSGF---HAMPEEfLQLWY-LHKMGALRM 194
Cdd:cd23974   254 DQVSAYGFMTPDYGK----YSDHYYDKTYHKVVFyanHDLRLE-MQLWQkLHKAGLIKL 307
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 2-166 1.09e-07

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 50.64  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT----------QLVTANPSIIRQRFE--NLLWsrkkFVDNMKIYNHSY 69
Cdd:cd23979    95 SGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTthhfmypesaKNLPANVSFVLVPFKtlDLLW----ITSALSTGQIRF 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  70 IYMPafsmktgTEPSLRVyytlkdagANQTVLFANPNFLRNIGKFWKGRgiHAKRLSTGLFLVSAALGLCEEVSIYGfwp 149
Cdd:cd23979   170 TYAP-------VKQFLRV--------DKDKVQIYNPAFFKYIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYG--- 229

                         170
                  ....*....|....*..
gi 1958768273 150 FSVNMQGEpiSHHYYDN 166
Cdd:cd23979   230 FGADSRGN--WHHYWEN 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 2-165 8.69e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 47.62  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRQRFEN-LLWSRKKFVDNM-------KIYNHSYIYM 72
Cdd:cd23965    16 SGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSLPRLLRNAiLLLAGTRAPTVVvfwgpetKMNKDGAGKY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  73 PAFSMKTGTEPSLRVYYTlkdagANQTVLFANPNFLRNIGK------FWkgrgihakrLSTGLFLVSAALGLCEEVSIYG 146
Cdd:cd23965    95 NLLRSLSKKYPDVEFYSL-----TPEKMDYADELFEKETGKsriksgTW---------LSTGWFTMLLALDVCDEIKVYG 160

                         170       180
                  ....*....|....*....|.
gi 1958768273 147 FWP--FSVNMQGEPISHHYYD 165
Cdd:cd23965   161 MVPenYCREHPNSKVPYHYYE 181
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 2-179 2.33e-06

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 46.88  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKT-------QLVTAN-----PSIIRQRFENLLWSRKKFVDNMKI--YNH 67
Cdd:cd23968    60 SKLGKEIDSHDAVLRFNDAPTK-GFEKDVGSKTtlrlinsQILSKPefnflTDPLYRNVTLLVWDPSSYNVNLEKwyKKP 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  68 SYIYMPAFSMKTGTEPSLRVYytlkdaganqtvlFANPNFLRN----IGKFWKGRgIHAKRLSTGLFLVSAALGLCEEVS 143
Cdd:cd23968   139 DFDFFPNYIKYRRRHPEEPFY-------------LIDPRFLWRlwdiLQEYTPEK-IKPNPPSSGFIGIVLMLHLCDWVD 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958768273 144 IYGFWPfSVnmqGEPISHHYYDNVL----PFSGFHAMPEE 179
Cdd:cd23968   205 VYEYVP-SV---RQTDRCHYYDVEKdlacTLGAWHPLAAE 240
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 5-194 3.29e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 46.74  E-value: 3.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   5 GRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLV-----TANPSIIRqrFENLLWSRKKFVDNMKiynhsYIYMPAfsmkt 79
Cdd:cd23972   100 GRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFYgftvnTMKNSLIS--YWNLGFTRTPQGQDLQ-----YIFIPS----- 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  80 gtepSLRVYYTLK------------DAGANQTVLFA-----------NPNFLRNI-GKFWKGRGI-----HAKRLSTGLF 130
Cdd:cd23972   167 ----DIRDYVMLRsailgvpvpeglDKGDRPHKYFGpeasakkfkllHPDFISYLtDRFLKSKLLnthygHLYMPSTGAL 242

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768273 131 LVSAALGLCEEVSIYGFwpfsVNMQGEPISHHYYDNV---LPFSGFHAMPEEfLQLW-YLHKMGALRM 194
Cdd:cd23972   243 MLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKkkpLVFYANHDMLLE-AALWrRLHKAGILQL 305
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 2-189 6.84e-06

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 44.98  E-value: 6.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SIIRQRFEN---------------LLW-----SRKKFVD 60
Cdd:cd23967    17 KSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYPeSAFRDPEEYdsdwllvlvpfksmdLLWlqaviKGKKPNG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  61 NmkiynhsyiympAFSMKtgtEPSLRVYYTLKDaganqtVLFANPNFLR----NIGKFWKGRGIHAKRLSTGLFLVSAAL 136
Cdd:cd23967    96 K------------GGFWK---KIATSVPKPPKK------IRILNPYILQeaafDLIGLPMNGKQGKNVPTTGIIAIVMAL 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768273 137 GLCEEVSIYGFwPFSVNMQGEPIshHYYDNVL----PFSGFHAMPEEFLqlwYLHKM 189
Cdd:cd23967   155 HYCDEVDIAGF-GYDPSDPNAPL--HYYDSLTmkaiKRSWTHNVTKEKK---YLKKL 205
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 2-194 2.85e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 43.59  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLlwsRKKFVDNMKIYNH-SYIYMPAfsmktg 80
Cdd:cd23973    98 SKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFYVHTAHSITSSLMIL---QKRGFKNIPQDKDiKYILFPE------ 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  81 tepSLRVYYTLKDAGANQTV-----------------------LFANPNFLRNI-GKFWKGRGIHAK-----RLSTGLFL 131
Cdd:cd23973   168 ---GPRDYQWLEALLKNKTIpsgayygrrprsyfsgdftedkyLVLHPDFLRYVkNRFLRSKTLKGKywaiyRPTTGAFL 244

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768273 132 VSAALGLCEEVSIYGFwpfsVNMQGEPISHHYYDNV---LPFSGFHAMPEEfLQLW-YLHKMGALRM 194
Cdd:cd23973   245 LLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKktkLVFYINHDFRLE-KKLWkRLHDEKIIKL 306
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 2-168 9.93e-05

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 41.57  E-value: 9.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQL-------VTANPSIIRQRFENLLWSRKKFVDNMKIYNhsyiympa 74
Cdd:cd23982    17 SSLGDVIDSYDVVIRLNDAPVR-GFEKDVGSKTTIrlfypesAQFDPGIENDPDTLLVLVPFKPLDFYWLYE-------- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768273  75 fsMKTGTEPSLRVYYT----LKDAGANQT-VLfaNPNFLRNIG-KFWKGRGIHAK--RLSTGLFLVSAALGLCEEVSIYG 146
Cdd:cd23982    88 --ILSNEKRVRKGFWKqpprIWDANPKQIrIL--NPYYTYVAAtKLLQVPGQRKKkqKPTTGLLAITLALHLCDEVHIAG 163

                         170       180
                  ....*....|....*....|...
gi 1958768273 147 F-WPFSVNmQGEPIshHYYDNVL 168
Cdd:cd23982   164 FgYPDNGN-SNQPI--HYYNQIT 183
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 2-38 5.72e-03

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 36.61  E-value: 5.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958768273   2 SGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT-------QLVT 38
Cdd:cd23985    60 SGLGREIDSHDAVLRFNGAP-TAGFQQDVGTKTtirlinsQLVT 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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