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Conserved domains on  [gi|1958644405|ref|XP_038963935|]
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p53-induced death domain-containing protein 1 isoform X4 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-300 2.32e-38

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 2.32e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 128 DLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSLSTLQRLDLS 207
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 208 ENLLDTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLLTSVPpGLAHLPLITRLDLRDNQLRDLP--A 285
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPplA 269

                         170
                  ....*....|....*
gi 1958644405 286 ELLDAPFVRLQGNPL 300
Cdd:COG4886   270 NLTNLKTLDLSNNQL 284
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 428-460 9.23e-11

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


:

Pssm-ID: 463098  Cd Length: 34  Bit Score: 56.77  E-value: 9.23e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958644405 428 WNDLETHLEEEAPKRR-WARCQVPHFSWFLVVLR 460
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
ZU5 super family cl02517
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 330-403 6.30e-07

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


The actual alignment was detected with superfamily member pfam00791:

Pssm-ID: 470600  Cd Length: 97  Bit Score: 47.91  E-value: 6.30e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958644405 330 SFLVTPHGCSVTLA-CGVRLQFPAGATTTPITIHYRLWLP--EPGLVSLGPHDFLLSGVLELQPHGVAFQQNVSLWL 403
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGTRIECYLAVNrdESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEV 78
ZU5 super family cl02517
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 471-544 4.38e-05

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


The actual alignment was detected with superfamily member pfam00791:

Pssm-ID: 470600  Cd Length: 97  Bit Score: 42.51  E-value: 4.38e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958644405 471 EGALLCSSgHPGVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLsqsGPP--SFLQPVTVQLP 544
Cdd:pfam00791   8 RGGRLVLP-NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-300 2.32e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 2.32e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 128 DLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSLSTLQRLDLS 207
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 208 ENLLDTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLLTSVPpGLAHLPLITRLDLRDNQLRDLP--A 285
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPplA 269

                         170
                  ....*....|....*
gi 1958644405 286 ELLDAPFVRLQGNPL 300
Cdd:COG4886   270 NLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 129-288 3.92e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.04  E-value: 3.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 129 LACLAHLDLSFNRLE-TLPTCVLELHSLDALLLSHNCLS-ELPEALGALPTLTFLTVTHN-LLERLPPTLGSLSTLQRLD 205
Cdd:PLN00113  139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNqLVGQIPRELGQMKSLKWIY 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 206 LS-ENLLDTIPSEIGDLSSLRELNLASNRLQ-HLPASLAGLRSLRLLVLHSNLLT-SVPPGLAHLPLITRLDLRDNQLRD 282
Cdd:PLN00113  219 LGyNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG 298


                  ....*.
gi 1958644405 283 LPAELL 288
Cdd:PLN00113  299 EIPELV 304
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 134-300 2.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 134 HLDLS---FNRLETLPTCvlelHSLDALLLSHNCLSELpEALGALPTLTFLTVTHNLLERLPPtLGSLSTLQRLDLSENL 210
Cdd:cd21340     6 HLYLNdknITKIDNLSLC----KNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 211 LDTIpSEIGDLSSLRELNLASNRLQH------LPASLAGL-RSLRLLVLHSNLLTSVPPgLAHLPLITRLDLRDNQLRDL 283
Cdd:cd21340    80 ISVV-EGLENLTNLEELHIENQRLPPgekltfDPRSLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL 157

                         170       180
                  ....*....|....*....|....
gi 1958644405 284 pAELLDA----PFVR---LQGNPL 300
Cdd:cd21340   158 -EELLDLlsswPSLReldLTGNPV 180
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 428-460 9.23e-11

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


Pssm-ID: 463098  Cd Length: 34  Bit Score: 56.77  E-value: 9.23e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958644405 428 WNDLETHLEEEAPKRR-WARCQVPHFSWFLVVLR 460
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
LRR_8 pfam13855
Leucine rich repeat;
222-280 8.32e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 8.32e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958644405 222 SSLRELNLASNRLQHL-PASLAGLRSLRLLVLHSNLLTSVPPG-LAHLPLITRLDLRDNQL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 330-403 6.30e-07

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 47.91  E-value: 6.30e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958644405 330 SFLVTPHGCSVTLA-CGVRLQFPAGATTTPITIHYRLWLP--EPGLVSLGPHDFLLSGVLELQPHGVAFQQNVSLWL 403
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGTRIECYLAVNrdESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEV 78
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 471-544 4.38e-05

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 42.51  E-value: 4.38e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958644405 471 EGALLCSSgHPGVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLsqsGPP--SFLQPVTVQLP 544
Cdd:pfam00791   8 RGGRLVLP-NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 482-544 2.58e-04

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 40.80  E-value: 2.58e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958644405  482 GVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLSQSGpPSFLQPVTVQLP 544
Cdd:smart00218  22 GVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHG-ALFLRPVILEVP 83
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-300 2.32e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 146.62  E-value: 2.32e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 128 DLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSLSTLQRLDLS 207
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 208 ENLLDTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLLTSVPpGLAHLPLITRLDLRDNQLRDLP--A 285
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPplA 269

                         170
                  ....*....|....*
gi 1958644405 286 ELLDAPFVRLQGNPL 300
Cdd:COG4886   270 NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
119-301 1.36e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.31  E-value: 1.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 119 LTTLPASMRDLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSL 198
Cdd:COG4886   125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 199 STLQRLDLSENLLDTIPSEIGDLSSLRELNLASNRLQHLPaSLAGLRSLRLLVLHSNLLTSVPPgLAHLPLITRLDLRDN 278
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNN 282

                         170       180
                  ....*....|....*....|...
gi 1958644405 279 QLRDLPAELLDAPFVRLQGNPLG 301
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLL 305
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
118-284 1.24e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.14  E-value: 1.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 118 TLTTLPASMRDLACLAHLDLSFNRLetlptcVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGS 197
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGN 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 198 LSTLQRLDLSENLLDTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLLTSVPPGLAHLPLITRLDLRD 277
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSN 237


                  ....*..
gi 1958644405 278 NQLRDLP 284
Cdd:COG4886   238 NQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-287 4.22e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.24  E-value: 4.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 132 LAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNllerlpPTLGSLSTLQRLDLSENLL 211
Cdd:COG4886    52 LLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQL 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958644405 212 DTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLLTSVPPGLAHLPLITRLDLRDNQLRDLPAEL 287
Cdd:COG4886   126 TDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPL 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
119-289 6.69e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 6.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 119 LTTLPASMRDLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSL 198
Cdd:COG4886   148 LTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 199 STLQRLDLSENLLDTIP---------------------SEIGDLSSLRELNLASNRLQHLP----ASLAGLRSLRLLVLH 253
Cdd:COG4886   228 TNLETLDLSNNQLTDLPelgnltnleeldlsnnqltdlPPLANLTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLL 307

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958644405 254 SNLLTSVPPGLAHLPLITRLDLRDNQLRDLPAELLD 289
Cdd:COG4886   308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 129-288 3.92e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.04  E-value: 3.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 129 LACLAHLDLSFNRLE-TLPTCVLELHSLDALLLSHNCLS-ELPEALGALPTLTFLTVTHN-LLERLPPTLGSLSTLQRLD 205
Cdd:PLN00113  139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNqLVGQIPRELGQMKSLKWIY 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 206 LS-ENLLDTIPSEIGDLSSLRELNLASNRLQ-HLPASLAGLRSLRLLVLHSNLLT-SVPPGLAHLPLITRLDLRDNQLRD 282
Cdd:PLN00113  219 LGyNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSG 298


                  ....*.
gi 1958644405 283 LPAELL 288
Cdd:PLN00113  299 EIPELV 304
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 134-300 2.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 134 HLDLS---FNRLETLPTCvlelHSLDALLLSHNCLSELpEALGALPTLTFLTVTHNLLERLPPtLGSLSTLQRLDLSENL 210
Cdd:cd21340     6 HLYLNdknITKIDNLSLC----KNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 211 LDTIpSEIGDLSSLRELNLASNRLQH------LPASLAGL-RSLRLLVLHSNLLTSVPPgLAHLPLITRLDLRDNQLRDL 283
Cdd:cd21340    80 ISVV-EGLENLTNLEELHIENQRLPPgekltfDPRSLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL 157

                         170       180
                  ....*....|....*....|....
gi 1958644405 284 pAELLDA----PFVR---LQGNPL 300
Cdd:cd21340   158 -EELLDLlsswPSLReldLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
119-271 2.78e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 119 LTTLPASMRDLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLP------ 192
Cdd:COG4886   171 LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPelgnlt 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 193 ---------------PTLGSLSTLQRLDLSENLLDTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLL 257
Cdd:COG4886   251 nleeldlsnnqltdlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330

                         170
                  ....*....|....
gi 1958644405 258 TSVPPGLAHLPLIT 271
Cdd:COG4886   331 KGLLVTLTTLALSL 344
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-287 3.63e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.81  E-value: 3.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 119 LTTLPASMRDlaCLAHLDLSFNRLETLPTCVLElhSLDALLLSHNCLSELPEalgALPtltfltvthnllerlpptlgsl 198
Cdd:PRK15370  232 LTSIPATLPD--TIQEMELSINRITELPERLPS--ALQSLDLFHNKISCLPE---NLP---------------------- 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 199 STLQRLDLSENLLDTIPSEIGdlSSLRELNLASNRLQHLPASLAglRSLRLLVLHSNLLTSVPPGLAhlPLITRLDLRDN 278
Cdd:PRK15370  283 EELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKN 356


                  ....*....
gi 1958644405 279 QLRDLPAEL 287
Cdd:PRK15370  357 QITVLPETL 365
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-261 3.05e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 3.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 129 LACLAHLDLSFNRLETLptCVLE-LHSLDALLLSHNCLSELpEALGALPTLTFLTVTHNlleRLPP---------TLGSL 198
Cdd:cd21340    45 LTNLTHLYLQNNQIEKI--ENLEnLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ---RLPPgekltfdprSLAAL 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958644405 199 S-TLQRLDLSENLLDTIpSEIGDLSSLRELNLASNRLQHLPA---SLAGLRSLRLLVLHSNLLTSVP 261
Cdd:cd21340   119 SnSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
Peptidase_S68 pfam10461
Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex ...
 428-460 9.23e-11

Peptidase S68; This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.


Pssm-ID: 463098  Cd Length: 34  Bit Score: 56.77  E-value: 9.23e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958644405 428 WNDLETHLEEEAPKRR-WARCQVPHFSWFLVVLR 460
Cdd:pfam10461   1 WSDLPTQLRRGSKSRKcVARCSVPHFSWFMVVSR 34
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-287 1.45e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 1.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 122 LPASMRDLACLAHLDLSFNRLET-LPTCVLELHSLDALLLSHNCLS-ELPEALGALPTLTFLTVTHNLLE---------- 189
Cdd:PLN00113  372 IPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdm 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 190 ---------------RLPPTLGSlSTLQRLDLSENLLD-TIPSEIGDLSSLRELNLASNRLQ-HLPASLAGLRSLRLLVL 252
Cdd:PLN00113  452 pslqmlslarnkffgGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDL 530

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958644405 253 -HSNLLTSVPPGLAHLPLITRLDLRDNQLR-DLPAEL 287
Cdd:PLN00113  531 sHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
LRR_8 pfam13855
Leucine rich repeat;
222-280 8.32e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 8.32e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958644405 222 SSLRELNLASNRLQHL-PASLAGLRSLRLLVLHSNLLTSVPPG-LAHLPLITRLDLRDNQL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 160-262 1.78e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 1.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 160 LSHNCLS-ELPEALGALP-TLTFLTVTHNLLERLPPTlGSLSTLQRLDLSENLLD-TIPSEIGDLSSLRELNLASNRLQ- 235
Cdd:PLN00113  100 LSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVg 178

                          90       100
                  ....*....|....*....|....*..
gi 1958644405 236 HLPASLAGLRSLRLLVLHSNLLTSVPP 262
Cdd:PLN00113  179 KIPNSLTNLTSLEFLTLASNQLVGQIP 205
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-300 1.89e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 122 LPASMRDLACLAHLDLSFNRLE-TLPTCVLELHSLDALLLSHNCLS-ELPEALGALPTLTFLTVTHNLLE-RLPPTLGSL 198
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQL 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 199 STLQRLDL-SENLLDTIPSEIGDLSSLRELNLASNRLQ-HLPASLAGLRSLRLLVLHSNLLTS-VPPGLAHLPLITRLDL 275
Cdd:PLN00113  308 QNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLIL 387

                         170       180
                  ....*....|....*....|....*....
gi 1958644405 276 RDNQLRD-LPAELLDAPF---VRLQGNPL 300
Cdd:PLN00113  388 FSNSLEGeIPKSLGACRSlrrVRLQDNSF 416
LRR_8 pfam13855
Leucine rich repeat;
199-257 3.83e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.83e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958644405 199 STLQRLDLSENLLDTIPSEI-GDLSSLRELNLASNRLQHL-PASLAGLRSLRLLVLHSNLL 257
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 155-244 7.37e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.67  E-value: 7.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 155 LDALLLSHNCL-SELPEALGALPTLTFLTVTHNLLE-RLPPTLGSLSTLQRLDLSENLLD-TIPSEIGDLSSLRELNLAS 231
Cdd:PLN03150  420 IDGLGLDNQGLrGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNG 499

                          90
                  ....*....|....
gi 1958644405 232 NRLQ-HLPASLAGL 244
Cdd:PLN03150  500 NSLSgRVPAALGGR 513
LRR_8 pfam13855
Leucine rich repeat;
176-234 2.10e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.10e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958644405 176 PTLTFLTVTHNLLERLPP-TLGSLSTLQRLDLSENLLDTI-PSEIGDLSSLRELNLASNRL 234
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 191-278 9.09e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 191 LPPTLGSLSTLQRLDLSENLLD-TIPSEIGDLSSLRELNLASNRLQ-HLPASLAGLRSLRLLVLHSNLLTS-VPPGLAHL 267
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAALGGR 513

                          90
                  ....*....|..
gi 1958644405 268 PLI-TRLDLRDN 278
Cdd:PLN03150  514 LLHrASFNFTDN 525
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 330-403 6.30e-07

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 47.91  E-value: 6.30e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958644405 330 SFLVTPHGCSVTLA-CGVRLQFPAGATTTPITIHYRLWLP--EPGLVSLGPHDFLLSGVLELQPHGVAFQQNVSLWL 403
Cdd:pfam00791   2 SGLVDSRGGRLVLPnSGVSLLIPPGAIPEGTRIECYLAVNrdESSRPPLEEGETLLSPVVECGPPGLKFLKPVILEV 78
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
118-291 9.98e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.09  E-value: 9.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 118 TLTTLPASMRDLAclahldLSFNRLETLPTCVLELHSLDALllsHNCLSELPealgALPT-LTFLTVTHNLLERLPptlg 196
Cdd:PRK15387  336 SLPTLPSGLQELS------VSDNQLASLPTLPSELYKLWAY---NNRLTSLP----ALPSgLKELIVSGNRLTSLP---- 398

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 197 slstlqrldlsenlldTIPSEigdlssLRELNLASNRLQHLPASLAGLRSLRllvLHSNLLTSVPPGLAHLPLITRLDLR 276
Cdd:PRK15387  399 ----------------VLPSE------LKELMVSGNRLTSLPMLPSGLLSLS---VYRNQLTRLPESLIHLSSETTVNLE 453

                         170
                  ....*....|....*....
gi 1958644405 277 DNQL--RDLPA--ELLDAP 291
Cdd:PRK15387  454 GNPLseRTLQAlrEITSAP 472
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
118-292 4.71e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 4.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 118 TLTTLPASMRdlACLAHLDLSFNRLETLPTCVL-ELHSLDallLSHNCLSELPEALGalPTLTFLTVTHNLLERLPPTLG 196
Cdd:PRK15370  315 SLTALPETLP--PGLKTLEAGENALTSLPASLPpELQVLD---VSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 197 slSTLQRLDLSENLLDTIPSEIGDLSS--------LRELNLASNR----LQHLPASLA--GLRSLRLLVLHSNLLTSVPP 262
Cdd:PRK15370  388 --AALQIMQASRNNLVRLPESLPHFRGegpqptriIVEYNPFSERtiqnMQRLMSSVGyqGPRVLFAMGDFSIVRVTRPL 465

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958644405 263 GLAHLPLITRLDLRD-NQLRDLPAELLDAPF 292
Cdd:PRK15370  466 HQAVQGWLTNLEEEDvNQWRAFETEVNAAAF 496
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 132-295 5.54e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 5.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 132 LAHLDLSFNRLETLPT----CVLE--LHSLDALLLSHNCLS-----ELPEALGALPTLTFLTVTHN-----LLERLPPTL 195
Cdd:cd00116   110 LQELKLNNNGLGDRGLrllaKGLKdlPPALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNgigdaGIRALAEGL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 196 GSLSTLQRLDLSENLLDtiPSEIGDLS-------SLRELNLASNRL-----QHL-PASLAGLRSLRLLVLHSNLLT---- 258
Cdd:cd00116   190 KANCNLEVLDLNNNGLT--DEGASALAetlaslkSLEVLNLGDNNLtdagaAALaSALLSPNISLLTLSLSCNDITddga 267

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958644405 259 -SVPPGLAHLPLITRLDLRDNQL----RDLPAELLDAPFVRL 295
Cdd:cd00116   268 kDLAEVLAEKESLLELDLRGNKFgeegAQLLAESLLEPGNEL 309
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 121-216 3.07e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 121 TLPASMRDLACLAHLDLSFNRL-----ETLPTCVlELHSLDallLSHNCLS-ELPEALGALPTLTFLTVTHNLLE-RLPP 193
Cdd:PLN00113  490 AVPRKLGSLSELMQLKLSENKLsgeipDELSSCK-KLVSLD---LSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPK 565

                          90       100
                  ....*....|....*....|....
gi 1958644405 194 TLGSLSTLQRLDLSENLLD-TIPS 216
Cdd:PLN00113  566 NLGNVESLVQVNISHNHLHgSLPS 589
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-290 3.27e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 3.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 110 ALGACLHGtlttlpasMRDLACLAHLDLSFNRL-----ETLPTCvLELHSLDALLLSHNCLSELPEAL--GAL----PTL 178
Cdd:cd00116    69 GLQSLLQG--------LTKGCGLQELDLSDNALgpdgcGVLESL-LRSSSLQELKLNNNGLGDRGLRLlaKGLkdlpPAL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 179 TFLTVTHNLLERlpptlgslstlqrlDLSENLLDTIPSeigdLSSLRELNLASNRL-----QHLPASLAGLRSLRLLVLH 253
Cdd:cd00116   140 EKLVLGRNRLEG--------------ASCEALAKALRA----NRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLN 201

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958644405 254 SNLLTS-----VPPGLAHLPLITRLDLRDNQLRDLP-AELLDA 290
Cdd:cd00116   202 NNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGaAALASA 244
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
165-285 4.27e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 46.69  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 165 LSELPEALGAlpTLTFLTVTHNLLERLPPTLGSLSTLQrldLSENLLDTIPSEIgdlSSLRELNLASNRLQHLPASLAGL 244
Cdd:PRK15387  213 LTTLPDCLPA--HITTLVIPDNNLTSLPALPPELRTLE---VSGNQLTSLPVLP---PGLLELSIFSNPLTHLPALPSGL 284

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958644405 245 RSLRLLVLHSNLLTSVPPGLahlpliTRLDLRDNQLRDLPA 285
Cdd:PRK15387  285 CKLWIFGNQLTSLPVLPPGL------QELSVSDNQLASLPA 319
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 471-544 4.38e-05

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 42.51  E-value: 4.38e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958644405 471 EGALLCSSgHPGVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLsqsGPP--SFLQPVTVQLP 544
Cdd:pfam00791   8 RGGRLVLP-NSGVSLLIPPGAIPEGTRIECYLAVNRDESSRPPLEEGETLLSPVVEC---GPPglKFLKPVILEVP 79
LRR_8 pfam13855
Leucine rich repeat;
132-188 6.87e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 6.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958644405 132 LAHLDLSFNRLETLPTCVLE-LHSLDALLLSHNCLSEL-PEALGALPTLTFLTVTHNLL 188
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
119-302 9.81e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.54  E-value: 9.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 119 LTTLPASMRDLACLahlDLSFNRLETLPtcVLELHSLDALLLShNCLSELPEALGALPTLTFLTVTHNLLERLPPTLgsl 198
Cdd:PRK15387  234 LTSLPALPPELRTL---EVSGNQLTSLP--VLPPGLLELSIFS-NPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGL--- 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 199 stlQRLDLSENLLDTIPSEIGDL-----------------SSLRELNLASNRLQHLP----------------ASLAGLR 245
Cdd:PRK15387  305 ---QELSVSDNQLASLPALPSELcklwaynnqltslptlpSGLQELSVSDNQLASLPtlpselyklwaynnrlTSLPALP 381

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958644405 246 S-LRLLVLHSNLLTSVP--PG-----------LAHLPLIT----RLDLRDNQLRDLPAELL---DAPFVRLQGNPLGE 302
Cdd:PRK15387  382 SgLKELIVSGNRLTSLPvlPSelkelmvsgnrLTSLPMLPsgllSLSVYRNQLTRLPESLIhlsSETTVNLEGNPLSE 459
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-186 1.35e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.35e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958644405 123 PASMRDLA-CLAHLDLSFNRLETLpTCVLELHSLDALLLSHNCLS---ELPEALGALPTLTFLTVTHN 186
Cdd:cd21340   112 PRSLAALSnSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 208-287 1.62e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 208 ENLLDTIPSEIGDLSSLRELNLASNRLQ-HLPASLAGLRSLRLLVLHSNLLT-SVPPGLAHLPLITRLDLRDNQLR-DLP 284
Cdd:PLN03150  428 QGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVP 507


                  ...
gi 1958644405 285 AEL 287
Cdd:PLN03150  508 AAL 510
ZU5 smart00218
Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.
 482-544 2.58e-04

Domain present in ZO-1 and Unc5-like netrin receptors; Domain of unknown function.


Pssm-ID: 128514  Cd Length: 104  Bit Score: 40.80  E-value: 2.58e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958644405  482 GVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLSQSGpPSFLQPVTVQLP 544
Cdd:smart00218  22 GVRLIIPPGAIPQGTRYTCYLVVHKTLSTPPPLEEGETLLSPVVECGPHG-ALFLRPVILEVP 83
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 151-300 4.68e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 151 ELHSLDALLLSHNCLS-----ELPEALGALPTLTFLTVTHNLL-----ERLPPTLGSLSTLQRLDLSENlldtipsEIGD 220
Cdd:COG5238   234 GNKSLTTLDLSNNQIGdegviALAEALKNNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVN-------RIGD 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 221 ------------LSSLRELNLASNRL-----QHLPASLAGLRSLRLLVLHSNLLT-SVPPGLAHL----PLITRLDLRDN 278
Cdd:COG5238   307 egaialaeglqgNKTLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIGdEGAIALAKYlegnTTLRELNLGKN 386

                         170       180
                  ....*....|....*....|...
gi 1958644405 279 QLRDLPAE-LLDApfvrLQGNPL 300
Cdd:COG5238   387 NIGKQGAEaLIDA----LQTNRL 405
PLN03150 PLN03150
hypothetical protein; Provisional
 122-176 8.65e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 8.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958644405 122 LPASMRDLACLAHLDLSFNRLE-TLPTCVLELHSLDALLLSHNCLS-ELPEALGALP 176
Cdd:PLN03150  458 IPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
154-287 5.03e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 154 SLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSLSTLQRLDLSENLLDTIPSEIGDLSSLRELNLASNR 233
Cdd:COG4886     5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958644405 234 LQHLPASLAGLRSLRLLVLHSNlltsvpPGLAHLPLITRLDLRDNQLRDLPAEL 287
Cdd:COG4886    85 LLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEEL 132
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 132-258 5.78e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405 132 LAHLDLSFNRL-----ETLPTCVLELHSLDALLLSHNCLSE-----LPEALGALPTLTFLTVTHNLL-----ERLPPTLG 196
Cdd:COG5238   266 VETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIgaqgaIALAKALQ 345

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958644405 197 SLSTLQRLDLSENLLDTIPSE-----IGDLSSLRELNLASNRL-----QHLPASLAGLRsLRLLVLHSNLLT 258
Cdd:COG5238   346 ENTTLHSLDLSDNQIGDEGAIalakyLEGNTTLRELNLGKNNIgkqgaEALIDALQTNR-LHTLILDGNLIG 416
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 118-240 6.04e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 6.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644405  118 TLTTLPASMRDLACLAHLDLSFNR-LETLPTCVlELHSLDALLLSH---------------------NCLSELPEALGAL 175
Cdd:PLN03210   790 SLVELPSSIQNLHKLEHLEIENCInLETLPTGI-NLESLESLDLSGcsrlrtfpdistnisdlnlsrTGIEEVPWWIEKF 868

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958644405  176 PTLTFLTVTH-NLLERLPPTLGSLSTLQRLD------LSENLLDTIPSEIGdlsslrelNLASNRLQHLPAS 240
Cdd:PLN03210   869 SNLSFLDMNGcNNLQRVSLNISKLKHLETVDfsdcgaLTEASWNGSPSEVA--------MATDNIHSKLPST 932
LRR_8 pfam13855
Leucine rich repeat;
245-289 7.51e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958644405 245 RSLRLLVLHSNLLTSVPPG-LAHLPLITRLDLRDNQLRDLPAELLD 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFS 46
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 132-194 8.35e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 8.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958644405 132 LAHLDLSFNRLE-TLPTCVLELHSLDALLLSHNCLS-ELPEALGALPTLTFLTVTHNLLE-RLPPT 194
Cdd:PLN00113  525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPST 590
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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