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Conserved domains on  [gi|1958777279|ref|XP_038966217|]
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EF-hand calcium-binding domain-containing protein 7 isoform X2 [Rattus norvegicus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144950)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
104-168 2.87e-11

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.19  E-value: 2.87e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958777279 104 KADLLKSFKQLDVNDDGSILHSDLHKYLTK--RGEKMTQEEVNAVISLADVNANGKFDYVKFCKLYM 168
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 407-467 3.97e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 35.99  E-value: 3.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958777279 407 LSEIFEIIDLDGNGLISLEEYNFFeLRTSGEKCDEDAW-AVCREnFDTKKN-ELTRQGFMDLH 467
Cdd:cd00051     2 LREAFRLFDKDGDGTISADELKAA-LKSLGEGLSEEEIdEMIRE-VDKDGDgKIDFEEFLELM 62
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
104-168 2.87e-11

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.19  E-value: 2.87e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958777279 104 KADLLKSFKQLDVNDDGSILHSDLHKYLTK--RGEKMTQEEVNAVISLADVNANGKFDYVKFCKLYM 168
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00184 PTZ00184
calmodulin; Provisional
 68-169 1.97e-10

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 59.39  E-value: 1.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777279  68 GRNPS----QKTINKYWTPQTAKLNFDDFCIILS-KEKPT-SKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQE 141
Cdd:PTZ00184   41 GQNPTeaelQDMINEVDADGNGTIDFPEFLTLMArKMKDTdSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGEKLTDE 120

                          90       100
                  ....*....|....*....|....*...
gi 1958777279 142 EVNAVISLADVNANGKFDYVKFCKLYMA 169
Cdd:PTZ00184  121 EVDEMIREADVDGDGQINYEEFVKMMMS 148
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 106-166 5.21e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 52.55  E-value: 5.21e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958777279 106 DLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQEEVNAVISLADVNANGKFDYVKFCKL 166
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLEL 61
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-166 2.86e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.62  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777279  81 TPQTAKLNFDDFC-IILSKEKPTSKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGekMTQEEVNAVISLADVNANGKFD 159
Cdd:COG5126    44 TDGDGRISREEFVaGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALG--VSEEEADELFARLDTDGDGKIS 121


                  ....*..
gi 1958777279 160 YVKFCKL 166
Cdd:COG5126   122 FEEFVAA 128
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 407-467 3.97e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.99  E-value: 3.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958777279 407 LSEIFEIIDLDGNGLISLEEYNFFeLRTSGEKCDEDAW-AVCREnFDTKKN-ELTRQGFMDLH 467
Cdd:cd00051     2 LREAFRLFDKDGDGTISADELKAA-LKSLGEGLSEEEIdEMIRE-VDKDGDgKIDFEEFLELM 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
391-426 8.10e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 8.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958777279 391 RDETGELSLtSEFRSTLS----------EIFEIIDLDGNGLISLEE 426
Cdd:COG5126    80 TDGDGKISA-DEFRRLLTalgvseeeadELFARLDTDGDGKISFEE 124
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
104-168 2.87e-11

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.19  E-value: 2.87e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958777279 104 KADLLKSFKQLDVNDDGSILHSDLHKYLTK--RGEKMTQEEVNAVISLADVNANGKFDYVKFCKLYM 168
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00184 PTZ00184
calmodulin; Provisional
 68-169 1.97e-10

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 59.39  E-value: 1.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777279  68 GRNPS----QKTINKYWTPQTAKLNFDDFCIILS-KEKPT-SKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQE 141
Cdd:PTZ00184   41 GQNPTeaelQDMINEVDADGNGTIDFPEFLTLMArKMKDTdSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGEKLTDE 120

                          90       100
                  ....*....|....*....|....*...
gi 1958777279 142 EVNAVISLADVNANGKFDYVKFCKLYMA 169
Cdd:PTZ00184  121 EVDEMIREADVDGDGQINYEEFVKMMMS 148
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 106-166 5.21e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 52.55  E-value: 5.21e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958777279 106 DLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQEEVNAVISLADVNANGKFDYVKFCKL 166
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLEL 61
PTZ00183 PTZ00183
centrin; Provisional
 59-163 1.53e-08

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 54.31  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777279  59 QLYLALQHAGRNPSQKTINKYW----TPQTAKLNFDDFCIILSKE--KPTSKADLLKSFKQLDVNDDGSILHSDLHKYLT 132
Cdd:PTZ00183   38 ELKVAMRSLGFEPKKEEIKQMIadvdKDGSGKIDFEEFLDIMTKKlgERDPREEILKAFRLFDDDKTGKISLKNLKRVAK 117

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958777279 133 KRGEKMTQEEVNAVISLADVNANGKFDYVKF 163
Cdd:PTZ00183  118 ELGETITDEELQEMIDEADRNGDGEISEEEF 148
EFh_CREC_cab45 cd16225
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also ...
 104-157 2.57e-03

EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.


Pssm-ID: 320023 [Multi-domain]  Cd Length: 278  Bit Score: 40.36  E-value: 2.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958777279 104 KADLLKSFKQ-LDVNDDGSILHSDLHKYLTKRGEKMTQEEVNAVISLADVNANGK 157
Cdd:cd16225   210 KKERKKEFEEvIDLNHDGKVTKEELEEYMDPRNERHALNEAKQLIAVADENKDGK 264
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-166 2.86e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.62  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777279  81 TPQTAKLNFDDFC-IILSKEKPTSKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGekMTQEEVNAVISLADVNANGKFD 159
Cdd:COG5126    44 TDGDGRISREEFVaGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALG--VSEEEADELFARLDTDGDGKIS 121


                  ....*..
gi 1958777279 160 YVKFCKL 166
Cdd:COG5126   122 FEEFVAA 128
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 407-467 3.97e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.99  E-value: 3.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958777279 407 LSEIFEIIDLDGNGLISLEEYNFFeLRTSGEKCDEDAW-AVCREnFDTKKN-ELTRQGFMDLH 467
Cdd:cd00051     2 LREAFRLFDKDGDGTISADELKAA-LKSLGEGLSEEEIdEMIRE-VDKDGDgKIDFEEFLELM 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
391-426 8.10e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 8.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958777279 391 RDETGELSLtSEFRSTLS----------EIFEIIDLDGNGLISLEE 426
Cdd:COG5126    80 TDGDGKISA-DEFRRLLTalgvseeeadELFARLDTDGDGKISFEE 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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