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Conserved domains on  [gi|1958777283|ref|XP_038966219|]
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EF-hand calcium-binding domain-containing protein 7 isoform X4 [Rattus norvegicus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
123-187 7.18e-12

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.96  E-value: 7.18e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958777283 123 KADLLKSFKQLDVNDDGSILHSDLHKYLTK--RGEKMTQEEVNAVISLADVNANGKFDYVKFCKLYM 187
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
123-187 7.18e-12

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.96  E-value: 7.18e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958777283 123 KADLLKSFKQLDVNDDGSILHSDLHKYLTK--RGEKMTQEEVNAVISLADVNANGKFDYVKFCKLYM 187
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00184 PTZ00184
calmodulin; Provisional
 87-188 3.27e-11

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 60.55  E-value: 3.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777283  87 GRNPS----QKTINKYWTPQTAKLNFDDFCIILS-KEKPT-SKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQE 160
Cdd:PTZ00184   41 GQNPTeaelQDMINEVDADGNGTIDFPEFLTLMArKMKDTdSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGEKLTDE 120

                          90       100
                  ....*....|....*....|....*...
gi 1958777283 161 EVNAVISLADVNANGKFDYVKFCKLYMA 188
Cdd:PTZ00184  121 EVDEMIREADVDGDGQINYEEFVKMMMS 148
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 125-185 1.39e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 53.32  E-value: 1.39e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958777283 125 DLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQEEVNAVISLADVNANGKFDYVKFCKL 185
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLEL 61
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
100-185 1.33e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.62  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777283 100 TPQTAKLNFDDFC-IILSKEKPTSKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGekMTQEEVNAVISLADVNANGKFD 178
Cdd:COG5126    44 TDGDGRISREEFVaGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALG--VSEEEADELFARLDTDGDGKIS 121


                  ....*..
gi 1958777283 179 YVKFCKL 185
Cdd:COG5126   122 FEEFVAA 128
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
123-187 7.18e-12

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 59.96  E-value: 7.18e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958777283 123 KADLLKSFKQLDVNDDGSILHSDLHKYLTK--RGEKMTQEEVNAVISLADVNANGKFDYVKFCKLYM 187
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKleEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00184 PTZ00184
calmodulin; Provisional
 87-188 3.27e-11

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 60.55  E-value: 3.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777283  87 GRNPS----QKTINKYWTPQTAKLNFDDFCIILS-KEKPT-SKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQE 160
Cdd:PTZ00184   41 GQNPTeaelQDMINEVDADGNGTIDFPEFLTLMArKMKDTdSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGEKLTDE 120

                          90       100
                  ....*....|....*....|....*...
gi 1958777283 161 EVNAVISLADVNANGKFDYVKFCKLYMA 188
Cdd:PTZ00184  121 EVDEMIREADVDGDGQINYEEFVKMMMS 148
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 125-185 1.39e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 53.32  E-value: 1.39e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958777283 125 DLLKSFKQLDVNDDGSILHSDLHKYLTKRGEKMTQEEVNAVISLADVNANGKFDYVKFCKL 185
Cdd:cd00051     1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLEL 61
PTZ00183 PTZ00183
centrin; Provisional
 78-182 5.17e-09

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 54.31  E-value: 5.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777283  78 QLYLALQHAGRNPSQKTINKYW----TPQTAKLNFDDFCIILSKE--KPTSKADLLKSFKQLDVNDDGSILHSDLHKYLT 151
Cdd:PTZ00183   38 ELKVAMRSLGFEPKKEEIKQMIadvdKDGSGKIDFEEFLDIMTKKlgERDPREEILKAFRLFDDDKTGKISLKNLKRVAK 117

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958777283 152 KRGEKMTQEEVNAVISLADVNANGKFDYVKF 182
Cdd:PTZ00183  118 ELGETITDEELQEMIDEADRNGDGEISEEEF 148
EFh_CREC_cab45 cd16225
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also ...
 123-176 4.27e-04

EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.


Pssm-ID: 320023 [Multi-domain]  Cd Length: 278  Bit Score: 41.52  E-value: 4.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958777283 123 KADLLKSFKQ-LDVNDDGSILHSDLHKYLTKRGEKMTQEEVNAVISLADVNANGK 176
Cdd:cd16225   210 KKERKKEFEEvIDLNHDGKVTKEELEEYMDPRNERHALNEAKQLIAVADENKDGK 264
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
100-185 1.33e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.62  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777283 100 TPQTAKLNFDDFC-IILSKEKPTSKADLLKSFKQLDVNDDGSILHSDLHKYLTKRGekMTQEEVNAVISLADVNANGKFD 178
Cdd:COG5126    44 TDGDGRISREEFVaGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALG--VSEEEADELFARLDTDGDGKIS 121


                  ....*..
gi 1958777283 179 YVKFCKL 185
Cdd:COG5126   122 FEEFVAA 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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