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Conserved domains on  [gi|1958645829|ref|XP_038968973|]
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high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X6 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAS super family cl43642
PAS domain [Signal transduction mechanisms];
213-318 4.84e-13

PAS domain [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG2202:

Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 68.90  E-value: 4.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGD 292
Cdd:COG2202    15 ALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGS 94

                          90       100
                  ....*....|....*....|....*.
gi 1958645829 293 NIQQNVKIIPVIGQGGKIRHYVSIIR 318
Cdd:COG2202    95 LFWVELSISPVRDEDGEITGFVGIAR 120
PDE8 super family cl07304
PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. ...
 1-24 2.89e-04

PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. It is found with pfam00233.


The actual alignment was detected with superfamily member pfam08629:

Pssm-ID: 400795  Cd Length: 52  Bit Score: 38.62  E-value: 2.89e-04
                          10        20
                  ....*....|....*....|....
gi 1958645829   1 MGCAPSIHISDNRVSNPSDSDGED 24
Cdd:pfam08629   1 MGCAPSIHISDSGVIYHSCKDSDD 24
PleD super family cl34659
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 76-164 9.93e-04

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


The actual alignment was detected with superfamily member COG3706:

Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 39.89  E-value: 9.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829  76 VLLVftkEDSQCNGFY--RACEKAGFKCTVTKEVQTVLACFQDKLHDIIIIDHRNPrQMDAEAMCRSIRSSKLSENTVIV 153
Cdd:COG3706     4 ILVV---DDDPTNRKLlrRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMP-DMDGLELCRRLRADPRTADIPII 79

                          90
                  ....*....|.
gi 1958645829 154 GVVRRVDKEEV 164
Cdd:COG3706    80 FLTALDDEEDR 90
 
Name Accession Description Interval E-value
PAS COG2202
PAS domain [Signal transduction mechanisms];
213-318 4.84e-13

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 68.90  E-value: 4.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGD 292
Cdd:COG2202    15 ALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGS 94

                          90       100
                  ....*....|....*....|....*.
gi 1958645829 293 NIQQNVKIIPVIGQGGKIRHYVSIIR 318
Cdd:COG2202    95 LFWVELSISPVRDEDGEITGFVGIAR 120
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 228-318 2.82e-10

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 56.70  E-value: 2.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 228 DHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAInsCVTIDKEWQGVYHTQKKNGDNIQQNVKIIPVIGQG 307
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREA--LREGKAVREFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|.
gi 1958645829 308 GKIRHYVSIIR 318
Cdd:pfam13426  79 GELVGIIAILR 89
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 224-318 1.60e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 49.17  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 224 ITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGDNIQQNVKIIPV 303
Cdd:cd00130     7 VLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVLVSLTPI 86

                          90
                  ....*....|....*
gi 1958645829 304 IGQGGKIRHYVSIIR 318
Cdd:cd00130    87 RDEGGEVIGLLGVVR 101
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 213-318 2.31e-06

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 46.52  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVpineKKGDLLDAINSCV--TIDKEWQGVYHT---Q 287
Cdd:TIGR00229   7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLEL----IPEEDREEVRERIerRLEGEPEPVSEErrvR 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958645829 288 KKNGDNIQQNVKIIPVIGQGGkIRHYVSIIR 318
Cdd:TIGR00229  83 RKDGSEIWVEVSVSPIRTNGG-ELGVVGIVR 112
PDE8 pfam08629
PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. ...
 1-24 2.89e-04

PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. It is found with pfam00233.


Pssm-ID: 400795  Cd Length: 52  Bit Score: 38.62  E-value: 2.89e-04
                          10        20
                  ....*....|....*....|....
gi 1958645829   1 MGCAPSIHISDNRVSNPSDSDGED 24
Cdd:pfam08629   1 MGCAPSIHISDSGVIYHSCKDSDD 24
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 213-257 4.76e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 38.53  E-value: 4.76e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958645829  213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQV 257
Cdd:smart00091   5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLEL 49
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 76-164 9.93e-04

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 39.89  E-value: 9.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829  76 VLLVftkEDSQCNGFY--RACEKAGFKCTVTKEVQTVLACFQDKLHDIIIIDHRNPrQMDAEAMCRSIRSSKLSENTVIV 153
Cdd:COG3706     4 ILVV---DDDPTNRKLlrRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMP-DMDGLELCRRLRADPRTADIPII 79

                          90
                  ....*....|.
gi 1958645829 154 GVVRRVDKEEV 164
Cdd:COG3706    80 FLTALDDEEDR 90
 
Name Accession Description Interval E-value
PAS COG2202
PAS domain [Signal transduction mechanisms];
213-318 4.84e-13

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 68.90  E-value: 4.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGD 292
Cdd:COG2202    15 ALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGS 94

                          90       100
                  ....*....|....*....|....*.
gi 1958645829 293 NIQQNVKIIPVIGQGGKIRHYVSIIR 318
Cdd:COG2202    95 LFWVELSISPVRDEDGEITGFVGIAR 120
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 228-318 2.82e-10

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 56.70  E-value: 2.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 228 DHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAInsCVTIDKEWQGVYHTQKKNGDNIQQNVKIIPVIGQG 307
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREA--LREGKAVREFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|.
gi 1958645829 308 GKIRHYVSIIR 318
Cdd:pfam13426  79 GELVGIIAILR 89
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 213-318 2.23e-08

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 52.03  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEWQGVYHTQK-KNG 291
Cdd:pfam00989   5 AILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFEVSFRvPDG 84

                          90       100
                  ....*....|....*....|....*..
gi 1958645829 292 DNIQQNVKIIPVIGQGGKIRHYVSIIR 318
Cdd:pfam00989  85 RPRHVEVRASPVRDAGGEILGFLGVLR 111
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 224-318 1.60e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 49.17  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 224 ITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEWQGVYHTQKKNGDNIQQNVKIIPV 303
Cdd:cd00130     7 VLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVLVSLTPI 86

                          90
                  ....*....|....*
gi 1958645829 304 IGQGGKIRHYVSIIR 318
Cdd:cd00130    87 RDEGGEVIGLLGVVR 101
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 213-318 1.61e-07

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 53.24  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVpinEKKGDLLDAINSCVTIdkewqgVYHTQKKNGD 292
Cdd:COG3829    15 AILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTEL---IPNSPLLEVLKTGKPV------TGVIQKTGGK 85

                          90       100
                  ....*....|....*....|....*.
gi 1958645829 293 NIQQNVKIIPVIgQGGKIRHYVSIIR 318
Cdd:COG3829    86 GKTVIVTAIPIF-EDGEVIGAVETFR 110
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
213-318 1.72e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 52.93  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKkgDLLDAINSCVTIDKE-WQGVYHTQKKNG 291
Cdd:COG3852    11 AILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDS--PLRELLERALAEGQPvTEREVTLRRKDG 88

                          90       100
                  ....*....|....*....|....*..
gi 1958645829 292 DNIQQNVKIIPVIGQGGKIrHYVSIIR 318
Cdd:COG3852    89 EERPVDVSVSPLRDAEGEG-GVLLVLR 114
PAS COG2202
PAS domain [Signal transduction mechanisms];
200-318 6.85e-07

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 50.41  E-value: 6.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 200 RSQLKLRAcnsvftALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCV-TIDK 278
Cdd:COG2202   134 ESEERLRL------LVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLeGGRE 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958645829 279 EWQGVYHTQKKNGDNIQQNVKIIPVIGqGGKIRHYVSIIR 318
Cdd:COG2202   208 SYELELRLKDGDGRWVWVEASAVPLRD-GGEVIGVLGIVR 246
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 213-318 2.31e-06

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 46.52  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVpineKKGDLLDAINSCV--TIDKEWQGVYHT---Q 287
Cdd:TIGR00229   7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLEL----IPEEDREEVRERIerRLEGEPEPVSEErrvR 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958645829 288 KKNGDNIQQNVKIIPVIGQGGkIRHYVSIIR 318
Cdd:TIGR00229  83 RKDGSEIWVEVSVSPIRTNGG-ELGVVGIVR 112
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 201-318 2.16e-05

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 46.51  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 201 SQLKLRacnsvfTALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTIDKEW 280
Cdd:COG5809   139 SEEKFR------LIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQLLKDGGIA 212

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958645829 281 QGVYHTQKKNGDNIQQNVKIIPvIGQGGKIRHYVSIIR 318
Cdd:COG5809   213 QGEVRFWTKDGRWRLLEASGAP-IKKNGEVDGIVIIFR 249
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 215-318 1.90e-04

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 43.57  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 215 LEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAINScvtIDKEWQ-GVYHTQK--KNG 291
Cdd:COG5805   163 IENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIES---ITEVWQeFIIEREIitKDG 239

                          90       100
                  ....*....|....*....|....*..
gi 1958645829 292 DNIQQNVKIIPVIGQGGKIRHYVSIIR 318
Cdd:COG5805   240 RIRYFEAVIVPLIDTDGSVKGILVILR 266
PDE8 pfam08629
PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. ...
 1-24 2.89e-04

PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. It is found with pfam00233.


Pssm-ID: 400795  Cd Length: 52  Bit Score: 38.62  E-value: 2.89e-04
                          10        20
                  ....*....|....*....|....
gi 1958645829   1 MGCAPSIHISDNRVSNPSDSDGED 24
Cdd:pfam08629   1 MGCAPSIHISDSGVIYHSCKDSDD 24
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 213-257 4.76e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 38.53  E-value: 4.76e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958645829  213 TALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQV 257
Cdd:smart00091   5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLEL 49
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 212-316 5.81e-04

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 42.03  E-value: 5.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 212 FTALEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGK--------ELAQVPINEKKGdlLDAINSCVTIDKEWqgv 283
Cdd:COG5805    37 ETILENLPDAIIAVNREGKVIYINPAMEKLLGYTSEEIIGKtifdflekEYHYRVKTRIER--LQKGYDVVMIEQIY--- 111

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958645829 284 yhtqKKNGDNIQQNVKIIPVIGQGGKIRHYVSI 316
Cdd:COG5805   112 ----CKDGELIYVEVKLFPIYNQNGQAAILALR 140
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 76-164 9.93e-04

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 39.89  E-value: 9.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829  76 VLLVftkEDSQCNGFY--RACEKAGFKCTVTKEVQTVLACFQDKLHDIIIIDHRNPrQMDAEAMCRSIRSSKLSENTVIV 153
Cdd:COG3706     4 ILVV---DDDPTNRKLlrRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMP-DMDGLELCRRLRADPRTADIPII 79

                          90
                  ....*....|.
gi 1958645829 154 GVVRRVDKEEV 164
Cdd:COG3706    80 FLTALDDEEDR 90
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 67-231 1.26e-03

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 40.15  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829  67 MRFHQdQLQVLLVftkEDSQCNGFY--RACEKAGFKCTVTKEVQTVLACFQDKLHDIIIIDHRNPRqMDAEAMCRSIRSS 144
Cdd:COG3437     1 MRTGQ-APTVLIV---DDDPENLELlrQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPG-MDGFELLRLLRAD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 145 KLSENTVIVGVVRRVDKEEVSLmpFLAAGFTrRYIENPNVMAcynELLQLafgeVRSQLKLRACNsvfTALEKSQEAIEI 224
Cdd:COG3437    76 PSTRDIPVIFLTALADPEDRER--ALEAGAD-DYLTKPFDPE---ELLAR----VRNALELRRLQ---RELDDLVLYLKL 142


                  ....*..
gi 1958645829 225 TSEDHII 231
Cdd:COG3437   143 AAPLHDI 149
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 200-318 6.16e-03

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 38.80  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829 200 RSQLKLRACNSVFTAL-EKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQV--PINEKKGDLLDAINSCVTI 276
Cdd:COG5809     5 KMELQLRKSEQRFRSLfENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFlhPDDEKELREILKLLKEGES 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958645829 277 DKEWQgvYHTQKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIR 318
Cdd:COG5809    85 RDELE--FELRHKNGKRLEFSSKLSPIFDQNGDIEGMLAISR 124
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 76-175 7.66e-03

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 36.37  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645829  76 VLLVftkEDSQCNGFY--RACEKAGFKCTVTKEVQTVLACFQDKLHDIIIIDHRNPRqMDAEAMCRSIRSSKLSENTVIV 153
Cdd:COG0784     8 ILVV---DDNPDNRELlrRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPG-MDGLELLRRIRALPRLPDIPII 83

                          90       100
                  ....*....|....*....|..
gi 1958645829 154 GVVRRVDKEEVSLmpFLAAGFT 175
Cdd:COG0784    84 ALTAYADEEDRER--ALEAGAD 103
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 215-271 8.86e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 35.85  E-value: 8.86e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958645829 215 LEKSQEAIEITSEDHIIQYANPAFETTMGYQSGELIGKELAQVPINEKKGDLLDAIN 271
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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