NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217264382|ref|XP_047303064|]
View 

zinc finger protein 362 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10604075)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 325-377 7.94e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 7.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217264382 325 GDRPYKCPHPGCEKAFTQLSNLQSHQRQ---------------HN----KDKPYKCPNCYRAYSDSASLQIH 377
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHghqnqklhenpspekMNifsaKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 3.00e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 2217264382 287 YLAQHLRIHLGVKPYHCSYCDKSFRQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 273-295 6.45e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.45e-04
                          10        20
                  ....*....|....*....|...
gi 2217264382 273 HKCPHCSKSFANASYLAQHLRIH 295
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 1.16e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217264382 259 EMQIHSKSHTEAKPHKCPHCSKSFAN 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
45-143 1.37e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14971:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 614  Bit Score: 40.91  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382  45 PPPTMPSQLDNLVLINKIKEQLMAEKIRPPHLPPTSASSQQPLLVPPA-PAESSQAVMSLPKLQQVP----GLHPQAVPQ 119
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSAtQPAGTPPTVSVDPPAAVPvnppSTAPQAVRP 449

                          90       100
                  ....*....|....*....|....
gi 2217264382 120 PDVALHARPATSTVTGLGLSTRTP 143
Cdd:PRK14971  450 AQFKEEKKIPVSKVSSLGPSTLRP 473
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 325-377 7.94e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 7.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217264382 325 GDRPYKCPHPGCEKAFTQLSNLQSHQRQ---------------HN----KDKPYKCPNCYRAYSDSASLQIH 377
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHghqnqklhenpspekMNifsaKDKPYRCEVCDKRYKNLNGLKYH 417
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 299-365 1.76e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.93  E-value: 1.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217264382 299 KPYhCSYCDKSFRQLSHLQQHTRIHTgdrpYKCPHpgCEKAFTQLSNLQSHQRQHNKDKPYKCPNCY 365
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHI--CHKKLYTAGGLAVHCLQVHKETLTKVPNAL 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 3.00e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 2217264382 287 YLAQHLRIHLGVKPYHCSYCDKSFRQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-342 7.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.84e-05
                          10        20
                  ....*....|....*....|....*...
gi 2217264382 315 HLQQHTRIHTGDRPYKCPHpgCEKAFTQ 342
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 273-295 6.45e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.45e-04
                          10        20
                  ....*....|....*....|...
gi 2217264382 273 HKCPHCSKSFANASYLAQHLRIH 295
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217264382 259 EMQIHSKSHTEAKPHKCPHCSKSFAN 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
45-143 1.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.91  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382  45 PPPTMPSQLDNLVLINKIKEQLMAEKIRPPHLPPTSASSQQPLLVPPA-PAESSQAVMSLPKLQQVP----GLHPQAVPQ 119
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSAtQPAGTPPTVSVDPPAAVPvnppSTAPQAVRP 449

                          90       100
                  ....*....|....*....|....
gi 2217264382 120 PDVALHARPATSTVTGLGLSTRTP 143
Cdd:PRK14971  450 AQFKEEKKIPVSKVSSLGPSTLRP 473
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 325-377 7.94e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 7.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217264382 325 GDRPYKCPHPGCEKAFTQLSNLQSHQRQ---------------HN----KDKPYKCPNCYRAYSDSASLQIH 377
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHghqnqklhenpspekMNifsaKDKPYRCEVCDKRYKNLNGLKYH 417
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 299-365 1.76e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.93  E-value: 1.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217264382 299 KPYhCSYCDKSFRQLSHLQQHTRIHTgdrpYKCPHpgCEKAFTQLSNLQSHQRQHNKDKPYKCPNCY 365
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHI--CHKKLYTAGGLAVHCLQVHKETLTKVPNAL 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 3.00e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 2217264382 287 YLAQHLRIHLGVKPYHCSYCDKSFRQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-342 7.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.84e-05
                          10        20
                  ....*....|....*....|....*...
gi 2217264382 315 HLQQHTRIHTGDRPYKCPHpgCEKAFTQ 342
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 301-323 1.82e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|...
gi 2217264382 301 YHCSYCDKSFRQLSHLQQHTRIH 323
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 273-295 6.45e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.45e-04
                          10        20
                  ....*....|....*....|...
gi 2217264382 273 HKCPHCSKSFANASYLAQHLRIH 295
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-425 6.83e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382 271 KPHKCPHCSKSFANASYLAQHLRIHL----GVKPYHC--SYCDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLS 344
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382 345 NLQSHQRQH-----NKDKPYKC--PNCYRAYSDSASLQIHLSAHAIKHAKAYCCSMCGRAYTSETYLMKHMSKHTvvEHL 417
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT--NHA 445


                  ....*...
gi 2217264382 418 VSHHSPQR 425
Cdd:COG5048   446 PLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
299-373 6.95e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217264382 299 KPYHCSYCDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHNKDKPYKCPNCYRAYSDSAS 373
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217264382 259 EMQIHSKSHTEAKPHKCPHCSKSFAN 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
45-143 1.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.91  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382  45 PPPTMPSQLDNLVLINKIKEQLMAEKIRPPHLPPTSASSQQPLLVPPA-PAESSQAVMSLPKLQQVP----GLHPQAVPQ 119
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSAtQPAGTPPTVSVDPPAAVPvnppSTAPQAVRP 449

                          90       100
                  ....*....|....*....|....
gi 2217264382 120 PDVALHARPATSTVTGLGLSTRTP 143
Cdd:PRK14971  450 AQFKEEKKIPVSKVSSLGPSTLRP 473
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-369 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....*
gi 2217264382 345 NLQSHQRQHNKDKPYKCPNCYRAYS 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-400 3.86e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382 271 KPHKCPHCSKSFANASYLAQHLRIHLGVKPYHCSY--CDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQS 348
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217264382 349 HQRQHNkdkPYKCPNCYRAYSDSASLQIHLSAHAIKHAKAYCCSMCGRAYTS 400
Cdd:COG5048   112 SSSSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVN 160
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 74-144 4.78e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 39.33  E-value: 4.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264382  74 PHLPPTSASSQQPllvPPAPAESSQAVMSlPKLQQVPGLHPQAVPQPDVALHARPA---TSTVTGLGLSTRTPS 144
Cdd:PHA03269   70 LAQAPTPAASEKF---DPAPAPHQAASRA-PDPAVAPQLAAAPKPDAAEAFTSAAQaheAPADAGTSAASKKPD 139
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
245-378 6.86e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 6.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382 245 YRCKVCPLTFFTKS--EMQIHSKSHT--EAKPHKCPH--CSKSFANASYLAQHLRIHLGVKPYHCSY------------- 305
Cdd:COG5048   290 IKSKQCNISFSRSSplTRHLRSVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnssskfspllnn 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264382 306 ------------------------CDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHNKdKPYKC 361
Cdd:COG5048   370 eppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTN-HAPLL 448

                         170
                  ....*....|....*..
gi 2217264382 362 PNCYRAYSDSASLQIHL 378
Cdd:COG5048   449 CSILKSFRRDLDLSNHG 465
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 329-353 7.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.87e-03
                          10        20
                  ....*....|....*....|....*
gi 2217264382 329 YKCPHpgCEKAFTQLSNLQSHQRQH 353
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH