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Conserved domains on  [gi|292614249|ref|XP_683313|]
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leucine-rich repeat and WD repeat-containing protein 1 isoform X1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-106 6.29e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  24 KLDQIKTLNLSRMSLksEDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDVLSLEALTNLEELR 102
Cdd:COG4886  180 NLTNLKELDLSNNQI--TDLPEPL-GNLTNLEELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELD 256


                 ....
gi 292614249 103 LEDN 106
Cdd:COG4886  257 LSNN 260
WD40 super family cl43672
WD40 repeat [General function prediction only];
399-587 4.70e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 4.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 399 DDFSTQLWACA-------FEPQQDD--SIDISGGSQTIATCGG-ETLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsR 468
Cdd:COG2319   98 ADGTVRLWDLAtglllrtLTGHTGAvrSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-----P 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 469 TGgsarpcNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKpTFLFTGTYDKKIFLWDIGGLDQdynfkis 548
Cdd:COG2319  173 DG------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKL------- 238

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 292614249 549 kLLTLET-SSTPLHLALlpsSPD-THLLSGCDEG-LYCFDVQ 587
Cdd:COG2319  239 -LRTLTGhSGSVRSVAF---SPDgRLLASGSADGtVRLWDLA 276
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-106 6.29e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  24 KLDQIKTLNLSRMSLksEDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDVLSLEALTNLEELR 102
Cdd:COG4886  180 NLTNLKELDLSNNQI--TDLPEPL-GNLTNLEELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELD 256


                 ....
gi 292614249 103 LEDN 106
Cdd:COG4886  257 LSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-135 2.37e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  48 LSKLCRLEKLDLSGN------------ML-------QKIPKGLRL-----------PCLKILNCSNNDMEDVLSLEALTN 97
Cdd:cd21340   64 LENLVNLKKLYLGGNrisvveglenltNLeelhienQRLPPGEKLtfdprslaalsNSLRVLNISGNNIDSLEPLAPLRN 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 292614249  98 LEELRLEDNL---------------YLT--------VNDEHK----VIFLLPNLRMFNGKDISST 135
Cdd:cd21340  144 LEQLDASNNQisdleelldllsswpSLReldltgnpVCKKPKyrdkIILASKSLEVLDGKEITDT 208
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 74-110 3.03e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.85  E-value: 3.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 292614249   74 PCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLT 110
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKIT 37
WD40 COG2319
WD40 repeat [General function prediction only];
399-587 4.70e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 4.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 399 DDFSTQLWACA-------FEPQQDD--SIDISGGSQTIATCGG-ETLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsR 468
Cdd:COG2319   98 ADGTVRLWDLAtglllrtLTGHTGAvrSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-----P 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 469 TGgsarpcNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKpTFLFTGTYDKKIFLWDIGGLDQdynfkis 548
Cdd:COG2319  173 DG------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKL------- 238

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 292614249 549 kLLTLET-SSTPLHLALlpsSPD-THLLSGCDEG-LYCFDVQ 587
Cdd:COG2319  239 -LRTLTGhSGSVRSVAF---SPDgRLLASGSADGtVRLWDLA 276
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-106 6.29e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  24 KLDQIKTLNLSRMSLksEDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDVLSLEALTNLEELR 102
Cdd:COG4886  180 NLTNLKELDLSNNQI--TDLPEPL-GNLTNLEELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELD 256


                 ....
gi 292614249 103 LEDN 106
Cdd:COG4886  257 LSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-106 1.72e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  24 KLDQIKTLNLSRMSLKseDLPVPLlSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDVLSLEALTNLEELRL 103
Cdd:COG4886  203 NLTNLEELDLSGNQLT--DLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDL 279


                 ...
gi 292614249 104 EDN 106
Cdd:COG4886  280 SNN 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-135 2.37e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  48 LSKLCRLEKLDLSGN------------ML-------QKIPKGLRL-----------PCLKILNCSNNDMEDVLSLEALTN 97
Cdd:cd21340   64 LENLVNLKKLYLGGNrisvveglenltNLeelhienQRLPPGEKLtfdprslaalsNSLRVLNISGNNIDSLEPLAPLRN 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 292614249  98 LEELRLEDNL---------------YLT--------VNDEHK----VIFLLPNLRMFNGKDISST 135
Cdd:cd21340  144 LEQLDASNNQisdleelldllsswpSLReldltgnpVCKKPKyrdkIILASKSLEVLDGKEITDT 208
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-128 6.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249   8 KITEKILLEKSSTKTNKLDQIKTLNLSRMslksedlpvPLLSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDM 86
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQL 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 292614249  87 EDV-LSLEALTNLEELRLEDNLYLTVNDEhkvIFLLPNLRMFN 128
Cdd:COG4886  149 TDLpEPLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELD 188
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-106 6.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  24 KLDQIKTLNLSRMSLKseDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDV-LSLEALTNLEEL 101
Cdd:COG4886  157 NLTNLKSLDLSNNQLT--DLPEEL-GNLTNLKELDLSNNQITDLPEPLgNLTNLEELDLSGNQLTDLpEPLANLTNLETL 233


                 ....*
gi 292614249 102 RLEDN 106
Cdd:COG4886  234 DLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-124 2.14e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 2.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249  24 KLDQIKTLNLSRMSLKSedlpVPLLSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDvLSLEALTNLEELRL 103
Cdd:COG4886  226 NLTNLETLDLSNNQLTD----LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD-LKLKELELLLGLNS 300

                         90       100
                 ....*....|....*....|.
gi 292614249 104 EDNLYLTVNDEHKVIFLLPNL 124
Cdd:COG4886  301 LLLLLLLLNLLELLILLLLLT 321
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 74-110 3.03e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.85  E-value: 3.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 292614249   74 PCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLT 110
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKIT 37
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 53-97 6.39e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 6.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 292614249   53 RLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMedVLSLEALTN 97
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
WD40 COG2319
WD40 repeat [General function prediction only];
399-587 4.70e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 4.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 399 DDFSTQLWACA-------FEPQQDD--SIDISGGSQTIATCGG-ETLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsR 468
Cdd:COG2319   98 ADGTVRLWDLAtglllrtLTGHTGAvrSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-----P 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 469 TGgsarpcNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKpTFLFTGTYDKKIFLWDIGGLDQdynfkis 548
Cdd:COG2319  173 DG------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKL------- 238

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 292614249 549 kLLTLET-SSTPLHLALlpsSPD-THLLSGCDEG-LYCFDVQ 587
Cdd:COG2319  239 -LRTLTGhSGSVRSVAF---SPDgRLLASGSADGtVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
417-538 1.22e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 417 SIDISGGSQTIATCGGE-TLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsRTGgsarpcNILAAGGKRGCVKLIHPRV 495
Cdd:COG2319  293 SVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTGAVRSVAFS-----PDG------KTLASGSDDGTVRLWDLAT 361

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 292614249 496 NLAFGEFRVSRRAISIMRFNPRKPTfLFTGTYDKKIFLWDIGG 538
Cdd:COG2319  362 GELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
417-580 1.39e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 417 SIDISGGSQTIATCGGE-TLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsRTGgsarpcNILAAGGKRGCVKLIHPRV 495
Cdd:COG2319  251 SVAFSPDGRLLASGSADgTVRLWDLATGELLRTLTGHSGGVNSVAFS-----PDG------KLLASGSDDGTVRLWDLAT 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249 496 NLAFGEFRVSRRAISIMRFNPrKPTFLFTGTYDKKIFLWDIGGLDQdynfkiskLLTLETSSTPLH-LALlpsSPD-THL 573
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGEL--------LRTLTGHTGAVTsVAF---SPDgRTL 387


                 ....*..
gi 292614249 574 LSGCDEG 580
Cdd:COG2319  388 ASGSADG 394
LRR_9 pfam14580
Leucine-rich repeat;
25-132 3.36e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292614249   25 LDQIKTLNLSRMSLKSEDlPVPLLSklcRLEKLDLSGNMLQKIPKGLR--LPCLKILNCSNNDME---DVLSLEALTNLE 99
Cdd:pfam14580  41 LDQFDTIDFSDNEIRKLD-GFPLLR---RLKTLLLNNNRICRIGEGLGeaLPNLTELILTNNNLQelgDLDPLASLKKLT 116

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 292614249  100 ELRLEDNlyLTVNDEH---KVIFLLPNLRMFNGKDI 132
Cdd:pfam14580 117 FLSLLRN--PVTNKPHyrlYVIYKVPQLRLLDFRKV 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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