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Conserved domains on  [gi|1207194650|ref|XP_685966|]
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zinc finger CCCH domain-containing protein 7B [Danio rerio]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-180 1.91e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  46 GNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLESLYvNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRK 125
Cdd:COG0457    83 GLALQALGRYEEALEDYDK-----------ALELDPDDAEALY-NLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207194650 126 ALCLRDQGRFREAYECGTGCLLTAPHDRQVSELAQDLANKLGLKIRKAYVSPQLD 180
Cdd:COG0457   151 GIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-180 1.91e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  46 GNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLESLYvNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRK 125
Cdd:COG0457    83 GLALQALGRYEEALEDYDK-----------ALELDPDDAEALY-NLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207194650 126 ALCLRDQGRFREAYECGTGCLLTAPHDRQVSELAQDLANKLGLKIRKAYVSPQLD 180
Cdd:COG0457   151 GIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 42-184 3.45e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 50.75  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  42 LLDEGNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLesLYVNRAAAHYSLGEYERGVQDCDSALCVSEGSRRA 121
Cdd:TIGR00990 130 LKEKGNKAYRNKDFNKAIKLYSK-----------AIECKPDPV--YYSNRAACHNALGDWEKVVEDTTAALELDPDYSKA 196

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207194650 122 LYRKALCLRDQGRFREA-YECGTGCLLTAPHDRQVSELAQDLANKLGLKIRKAYVS---PQLDSTTS 184
Cdd:TIGR00990 197 LNRRANAYDGLGKYADAlLDLTASCIIDGFRNEQSAQAVERLLKKFAESKAKEILEtkpENLPSVTF 263
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-180 1.91e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  46 GNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLESLYvNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRK 125
Cdd:COG0457    83 GLALQALGRYEEALEDYDK-----------ALELDPDDAEALY-NLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207194650 126 ALCLRDQGRFREAYECGTGCLLTAPHDRQVSELAQDLANKLGLKIRKAYVSPQLD 180
Cdd:COG0457   151 GIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-141 1.97e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  46 GNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLESLYvNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRK 125
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEK-----------ALELDPDDAEALY-NLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                          90
                  ....*....|....*.
gi 1207194650 126 ALCLRDQGRFREAYEC 141
Cdd:COG0457    83 GLALQALGRYEEALED 98
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-141 1.13e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  46 GNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLESLYvNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRK 125
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQ-----------ALELDPDDAEALN-NLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116

                          90
                  ....*....|....*.
gi 1207194650 126 ALCLRDQGRFREAYEC 141
Cdd:COG0457   117 GLALLELGRYDEAIEA 132
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
56-140 1.79e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  56 RQAAVHYSEGV--------NVARYAQSEALVIPPELLEsLYVNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRKAL 127
Cdd:COG4785    71 DLAQLYYERGVaydslgdyDLAIADFDQALELDPDLAE-AYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGI 149

                          90
                  ....*....|...
gi 1207194650 128 CLRDQGRFREAYE 140
Cdd:COG4785   150 ALYYLGRYELAIA 162
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 13-155 1.90e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  13 QKALGFIQSSLPFPEPEGYEAFLTQLVCNLLDEGNAVYRDGEWRQAAVHYSEGV-----------NVA-------RYAQS 74
Cdd:COG3914    52 AEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALalnpdnaealfNLGnlllalgRLEEA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  75 E-----ALVIPPELLEsLYVNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRKALCLRDQGRFREAYECGTGCLLTA 149
Cdd:COG3914   132 LaalrrALALNPDFAE-AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD 210


                  ....*.
gi 1207194650 150 PHDRQV 155
Cdd:COG3914   211 PDNADA 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-141 2.31e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 2.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207194650  77 LVIPPELLESLYvNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRKALCLRDQGRFREAYEC 141
Cdd:COG0457     1 LELDPDDAEAYN-NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALAD 64
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 42-184 3.45e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 50.75  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  42 LLDEGNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLesLYVNRAAAHYSLGEYERGVQDCDSALCVSEGSRRA 121
Cdd:TIGR00990 130 LKEKGNKAYRNKDFNKAIKLYSK-----------AIECKPDPV--YYSNRAACHNALGDWEKVVEDTTAALELDPDYSKA 196

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207194650 122 LYRKALCLRDQGRFREA-YECGTGCLLTAPHDRQVSELAQDLANKLGLKIRKAYVS---PQLDSTTS 184
Cdd:TIGR00990 197 LNRRANAYDGLGKYADAlLDLTASCIIDGFRNEQSAQAVERLLKKFAESKAKEILEtkpENLPSVTF 263
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 69-163 4.60e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.84  E-value: 4.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  69 ARYAQSEALVIPPELLEsLYVNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRKALCLRDQGRFREAYECGTGCLLT 148
Cdd:COG4235    36 ALAAYEKALRLDPDNAD-ALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114

                          90
                  ....*....|....*
gi 1207194650 149 APHDRQVSELAQDLA 163
Cdd:COG4235   115 LPADAPARLLEASIA 129
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 46-140 8.96e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 8.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  46 GNAVYRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLEsLYVNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRK 125
Cdd:COG4783    45 GEILLQLGDLDEAIVLLHE-----------ALELDPDEPE-ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRL 112

                          90
                  ....*....|....*
gi 1207194650 126 ALCLRDQGRFREAYE 140
Cdd:COG4783   113 ARAYRALGRPDEAIA 127
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 69-140 1.42e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 1.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207194650  69 ARYAQSEALVIPPELLEsLYVNRAAAHYSLGEYERGVQDCDSALCVSEGSRRALYRKALCLRDQGRFREAYE 140
Cdd:COG5010    73 SLALLEQALQLDPNNPE-LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
50-154 2.22e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  50 YRDGEWRQAAVHYSEgvnvaryaqseALVIPPELLESLYvNRAAAHYSLGEYERGVQdCDSALCVSEGSRRALYRKALCL 129
Cdd:COG3063     3 LKLGDLEEAEEYYEK-----------ALELDPDNADALN-NLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELL 69

                          90       100
                  ....*....|....*....|....*
gi 1207194650 130 RDQGRFREAYECGTGCLLTAPHDRQ 154
Cdd:COG3063    70 LELGDYDEALAYLERALELDPSALR 94
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
23-140 5.95e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194650  23 LPFPEPEGYEAFLTQLVCNLLDEGNAVYRDGEWRQAAVHYSEGVNVARYAQ--SEALVIPPELLE----SLYVNRAAAHY 96
Cdd:COG4785     5 ALALLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAaaLAAERIDRALALpdlaQLYYERGVAYD 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1207194650  97 SLGEYERGVQDCDSALCVSEGSRRALYRKALCLRDQGRFREAYE 140
Cdd:COG4785    85 SLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALE 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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