|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
281-557 |
2.36e-157 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 473.53 E-value: 2.36e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLYDNLVESLERYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLW 360
Cdd:cd18069 1 LKPHQIGGIRFLYDNIIESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 361 LPAAEALPpdtdpqQVLPRTFKVHILNDEHKTTVARAKVVEDWTGDGGVLLMGYEMYRLlslkksfvtgrkrkskkpagp 440
Cdd:cd18069 81 LPPPEALP------NVRPRPFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFRL--------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 441 viidldeedrqqelmkaieralsRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVR 520
Cdd:cd18069 134 -----------------------RPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVR 190
|
250 260 270
....*....|....*....|....*....|....*..
gi 189535029 521 PDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYR 557
Cdd:cd18069 191 PDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
281-557 |
1.90e-110 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 348.51 E-value: 1.90e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLYDNLVESleRYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHT-GAKTVLAIVPVNTLQNWLAEFNL 359
Cdd:cd18007 1 LKPHQVEGVRFLWSNLVGT--DVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAApRRSRPLVLCPASTLYNWEDEFKK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 360 WLPaaealpPDTDPqqvlprtFKVHILNDEHKTTVARAKVVEDWTGDGGVLLMGYEMYRLLSLKKSFVTGRKRKSkkpag 439
Cdd:cd18007 79 WLP------PDLRP-------LLVLVSLSASKRADARLRKINKWHKEGGVLLIGYELFRNLASNATTDPRLKQEF----- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 440 pviidldeedrqqelmkaiERALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFV 519
Cdd:cd18007 141 -------------------IAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFA 201
|
250 260 270
....*....|....*....|....*....|....*...
gi 189535029 520 RPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYR 557
Cdd:cd18007 202 RPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
185-887 |
1.40e-95 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 323.33 E-value: 1.40e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 185 LDSSGDEGEEKEAPPPPLPDHRDDVIELSSGDEGDALRISSEEEEDRSLTPGTEESSGSHINDSLNQPDSQGRVLININH 264
Cdd:COG0553 142 LAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDA 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 265 PAEEEDLFLAPQLARAVK----PHQIGGIRFLYdnlveSLERYktssGFGCILAHSMGLGKTLQVISFIDVLLRHTGAKT 340
Cdd:COG0553 222 FRLRRLREALESLPAGLKatlrPYQLEGAAWLL-----FLRRL----GLGGLLADDMGLGKTIQALALLLELKERGLARP 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 341 VLAIVPVNTLQNWLAEFNLWLPaaealppdtdpqqvlprTFKVHILNDEHKttvaRAKVVEDWtGDGGVLLMGYEMYRll 420
Cdd:COG0553 293 VLIVAPTSLVGNWQRELAKFAP-----------------GLRVLVLDGTRE----RAKGANPF-EDADLVITSYGLLR-- 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 421 slkksfvtgrkrkskkpagpviidldeedRQQELMKAIEralsrpgPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVL 500
Cdd:COG0553 349 -----------------------------RDIELLAAVD-------WDLVILDEAQHIKNPATKRAKAVRALKARHRLAL 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 501 TGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQcidstPQDVQLMRyrshvlhSLLEGFVQRR-GHDVLRh 579
Cdd:COG0553 393 TGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGD-----EEALERLR-------RLLRPFLLRRtKEDVLK- 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 580 QLPPKEEHVILVRLSRLQRALYTEFMNRFREAGNSG---------WLGLNPLKAFCvcckiwNHPDVLyealqkenLANE 650
Cdd:COG0553 460 DLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAegirrrgliLAALTRLRQIC------SHPALL--------LEEG 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 651 QDLDLDdlnsssgtrcsapgiksktsdaansrqmsvghlnplqekanqvityewakevmtnyqtgvlenSAKMVLLFYLI 730
Cdd:COG0553 526 AELSGR---------------------------------------------------------------SAKLEALLELL 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 731 DETVARGDKILVFSQSLSTLTVIEDFLSRRpmpiqtetgthnwvrNINYYRLDGSTSASERERLINQFNDPANtqAWVFL 810
Cdd:COG0553 543 EELLAEGEKVLVFSQFTDTLDLLEERLEER---------------GIEYAYLHGGTSAEERDELVDRFQEGPE--APVFL 605
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189535029 811 LSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQRKPCHIYRLVCDFTLEKKIYDRQVSKQGMSDRVVD 887
Cdd:COG0553 606 ISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
281-557 |
1.27e-81 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 268.29 E-value: 1.27e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLYDNLVESLERYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRH---TGAKTVLAIVPVNTLQNWLAEF 357
Cdd:cd18068 1 LKPHQVDGVQFMWDCCCESLKKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLLCeklENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 358 NLWLPAAEalppDTDpqqvlprTFKVHILnDEHKTTVARAKVVEDWTGDGGVLLMGYEMYRLLSlkksfvTGRKRKSKKP 437
Cdd:cd18068 81 EKWQEGLK----DEE-------KIEVNEL-ATYKRPQERSYKLQRWQEEGGVMIIGYDMYRILA------QERNVKSREK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 438 AgpviidldeedrQQELMKAieraLSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 517
Cdd:cd18068 143 L------------KEIFNKA----LVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVN 206
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 189535029 518 FVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYR 557
Cdd:cd18068 207 FVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVDVRVMKKR 246
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
284-638 |
9.72e-62 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 212.93 E-value: 9.72e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 284 HQIGGIRFLYDnlvesleRYkTSSGFGCILAHSMGLGKTLQVISFIDVLLRH---TGAKTvLAIVPVNTLQNWLAEFNLW 360
Cdd:pfam00176 1 YQIEGVNWMLS-------LE-NNLGRGGILADEMGLGKTLQTISLLLYLKHVdknWGGPT-LIVVPLSLLHNWMNEFERW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 361 lpaaeALPPDTdpqqvlpRTFKVHILNDEHKTTVARAKVVEDWtgdgGVLLMGYEMYRllslkksfvtgrKRKSKkpagp 440
Cdd:pfam00176 72 -----VSPPAL-------RVVVLHGNKRPQERWKNDPNFLADF----DVVITTYETLR------------KHKEL----- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 441 viidldeedrqqelmkaieraLSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVR 520
Cdd:pfam00176 119 ---------------------LKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLR 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 521 PDFLGTRQEFSNMFERPILNGQcidstpqdvqlMRYRSHVLHSLLEGFVQRRGHDVLRHQLPPKEEHVILVRLSRLQRAL 600
Cdd:pfam00176 178 PGPFGSLSTFRNWFDRPIERGG-----------GKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKLQRKL 246
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 189535029 601 YTEFMnRFRE--AGNSGWLGLNPLKAFCVCC----KIWNHPDVL 638
Cdd:pfam00176 247 YQTFL-LKKDlnAIKTGEGGREIKASLLNILmrlrKICNHPGLI 289
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
283-572 |
2.69e-59 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 204.06 E-value: 2.69e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 283 PHQIGGIRFLYDnlveSLERYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHT-----GAKTVLAIVPVNTLQNWLAEF 357
Cdd:cd18004 3 PHQREGVQFLYD----CLTGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGpygkpTAKKALIVCPSSLVGNWKAEF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 358 NLWLPaaealppdtdpqqvlPRTFKVHILNDEHKTTVArAKVVEDWTGDGGVLLMGYEMYRLLSlkksfvtgrkrkskkp 437
Cdd:cd18004 79 DKWLG---------------LRRIKVVTADGNAKDVKA-SLDFFSSASTYPVLIISYETLRRHA---------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 438 agpviidldeedrqQELMKAIeralsrpGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 517
Cdd:cd18004 127 --------------EKLSKKI-------SIDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVD 185
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 189535029 518 FVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRR 572
Cdd:cd18004 186 FVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
225-878 |
1.34e-55 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 211.58 E-value: 1.34e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 225 SEEEEDRSLTPGTEESSGSHINDSL-NQPDS-QGRVlininhpaeeedlflapqlaravKPHQIGGIRF---LYDNlves 299
Cdd:PLN03142 135 TEEEEDEEYLKEEEDGLGGSGGTRLlVQPSCiKGKM-----------------------RDYQLAGLNWlirLYEN---- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 300 leryktssGFGCILAHSMGLGKTLQVISFIDVLLRH---TGAKTVlaIVPVNTLQNWLAEFNLWLPaaealppdtdpqqV 376
Cdd:PLN03142 188 --------GINGILADEMGLGKTLQTISLLGYLHEYrgiTGPHMV--VAPKSTLGNWMNEIRRFCP-------------V 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 377 LpRTFKVHILNDEhkttvaRAKVVEDWTGDGG--VLLMGYEMyrllslkksfvtGRKRKSkkpagpviidldeedrqqel 454
Cdd:PLN03142 245 L-RAVKFHGNPEE------RAHQREELLVAGKfdVCVTSFEM------------AIKEKT-------------------- 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 455 mkaierALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 534
Cdd:PLN03142 286 ------ALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWF 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 535 ERPILNGQcidstpQDVqlmryrSHVLHSLLEGFVQRRGHDVLRHQLPPKEEHVILVRLSRLQRALYTEFMNRFREAGNS 614
Cdd:PLN03142 360 QISGENDQ------QEV------VQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNA 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 615 GwlG-----LNPLKAFCVCCkiwNHPdVLYEALQkenlaneqdldlddlnsssgtrcsaPGIKSKTSDaansrqmsvgHL 689
Cdd:PLN03142 428 G--GerkrlLNIAMQLRKCC---NHP-YLFQGAE-------------------------PGPPYTTGE----------HL 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 690 nplqekanqvityewakevmtnyqtgvLENSAKMVLLFYLIDETVARGDKILVFSQSLSTLTVIEDFLSrrpmpiqtetg 769
Cdd:PLN03142 467 ---------------------------VENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLM----------- 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 770 thnwVRNINYYRLDGSTSASERERLINQFNDPaNTQAWVFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYR 849
Cdd:PLN03142 509 ----YRGYQYCRIDGNTGGEDRDASIDAFNKP-GSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHR 583
|
650 660
....*....|....*....|....*....
gi 189535029 850 YGQRKPCHIYRLVCDFTLEKKIYDRQVSK 878
Cdd:PLN03142 584 IGQKKEVQVFRFCTEYTIEEKVIERAYKK 612
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
720-862 |
1.04e-52 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 181.14 E-value: 1.04e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 720 SAKMVLLFYLIDETVARGDKILVFSQSLSTLTVIEDFLSRRpmpiqtetgthnwvrNINYYRLDGSTSASERERLINQFN 799
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER---------------GIKYLRLDGSTSSKERQKLVDRFN 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189535029 800 DPANTQawVFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQRKPCHIYRLV 862
Cdd:cd18793 75 EDPDIR--VFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
282-524 |
2.14e-46 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 164.66 E-value: 2.14e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRFLydnlvesLERYKTssGFGCILAHSMGLGKTLQVISFIDVLLRHTGAKT-VLAIVPVNTLQNWLAEFNLW 360
Cdd:cd17919 2 RPYQLEGLNFL-------LELYEN--GPGGILADEMGLGKTLQAIAFLAYLLKEGKERGpVLVVCPLSVLENWEREFEKW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 361 LPaaealppdtdpqqvlprTFKVHILNDEHKTTVARAKVVedWTGDGGVLLMGYEMYRLLSlkksfvtgrkrkskkpagp 440
Cdd:cd17919 73 TP-----------------DLRVVVYHGSQRERAQIRAKE--KLDKFDVVLTTYETLRRDK------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 441 viidldeedrqqelmkaieRALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVR 520
Cdd:cd17919 115 -------------------ASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLD 175
|
....
gi 189535029 521 PDFL 524
Cdd:cd17919 176 PPFL 179
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
282-572 |
1.52e-40 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 150.61 E-value: 1.52e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRFLYDNLVEsleryktssGFGCILAHSMGLGKTLQVISFIDVLLRHTG---------------------AKT 340
Cdd:cd18005 2 RDYQREGVEFMYDLYKN---------GRGGILGDDMGLGKTVQVIAFLAAVLGKTGtrrdrennrprfkkkppassaKKP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 341 VLAIVPVNTLQNWLAEFNLWlpaaealppdtdpqqvlpRTFKVHILNDEHKTTV--ARAKvvedwTGDGGVLLMGYEMYR 418
Cdd:cd18005 73 VLIVAPLSVLYNWKDELDTW------------------GHFEVGVYHGSRKDDEleGRLK-----AGRLEVVVTTYDTLR 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 419 LlslkksfvtgrkrkskkpagpviiDLDEedrqqelmkaieraLSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRV 498
Cdd:cd18005 130 R------------------------CIDS--------------LNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRI 171
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189535029 499 VLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRR 572
Cdd:cd18005 172 GLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
281-572 |
3.27e-40 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 149.23 E-value: 3.27e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLYdnlvESLERYKTSSGFGCILAHSMGLGKTLQVISFIDVLLR--HTGAKTV----LAIVPVNTLQNWL 354
Cdd:cd18066 1 LRPHQREGIEFLY----ECVMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRqgPYGGKPVikraLIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 355 AEFNLWLPAAEalppdtdpqqvlprtFKVHILNDEHKttvarakvVEDWTGDG--GVLLMGYEMyrLLslkksfvtgrkr 432
Cdd:cd18066 77 KEFQKWLGSER---------------IKVFTVDQDHK--------VEEFIASPlySVLIISYEM--LL------------ 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 433 kskkpagpviidldeedRQQELMKAIERalsrpgpDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEY 512
Cdd:cd18066 120 -----------------RSLDQISKLNF-------DLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEF 175
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 513 WCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRR 572
Cdd:cd18066 176 FALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
281-572 |
3.70e-40 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 149.16 E-value: 3.70e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLYDNLVESLERyktsSGFGCILAHSMGLGKTLQVISFIDVLLRHT-GAKTVL--AIV--PVNTLQNWLA 355
Cdd:cd18067 1 LRPHQREGVKFLYRCVTGRRIR----GSHGCIMADEMGLGKTLQCITLMWTLLRQSpQCKPEIdkAIVvsPSSLVKNWAN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 356 EFNLWLPaaealpPDTDPQQVLPRTFKVHILNDEHKTTVARAKVVEDwtgdggVLLMGYEMYRLlslkksfvtgrkrksk 435
Cdd:cd18067 77 ELGKWLG------GRLQPLAIDGGSKKEIDRKLVQWASQQGRRVSTP------VLIISYETFRL---------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 436 kpagpviidldeedrQQELMKAIERALsrpgpdvVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCM 515
Cdd:cd18067 129 ---------------HVEVLQKGEVGL-------VICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSL 186
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 189535029 516 VDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRR 572
Cdd:cd18067 187 VNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
283-572 |
1.66e-37 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 141.35 E-value: 1.66e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 283 PHQIGGIRFLYdnlveSLEryktSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLWLP 362
Cdd:cd18001 3 PHQREGVAWLW-----SLH----DGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 363 AAealppdtdpqqvlpRTFKVHILNdehktTVARAKVVEDWTGDGGVLLMGYEMYRllslkksfvtgrkRKSKkpagpvi 442
Cdd:cd18001 74 GL--------------RVKVFHGTS-----KKERERNLERIQRGGGVLLTTYGMVL-------------SNTE------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 443 iDLDEEDRQQELMkaieralsrpgpDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRP- 521
Cdd:cd18001 115 -QLSADDHDEFKW------------DYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNg 181
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 189535029 522 DFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRR 572
Cdd:cd18001 182 SLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
283-524 |
1.79e-31 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 122.43 E-value: 1.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 283 PHQIGGIRFLYDnlvesleryKTSSGFGCILAHSMGLGKTLQVISFIDVL-LRHTGAKTVLAIVPVNTLQNWLAEFNLWL 361
Cdd:cd18000 3 KYQQTGVQWLWE---------LHCQRVGGILGDEMGLGKTIQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 362 PAAealppdtdpqqvlpRTFKVH------ILNDEHKTTVARAKVVEDWTGDGGVLLMGYEMYRLLSlkksfvtgrkrksk 435
Cdd:cd18000 74 PPF--------------RVVVLHssgsgtGSEEKLGSIERKSQLIRKVVGDGGILITTYEGFRKHK-------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 436 kpagpviidldeedrqqelmkaieRALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCM 515
Cdd:cd18000 126 ------------------------DLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSL 181
|
....*....
gi 189535029 516 VDFVRPDFL 524
Cdd:cd18000 182 FDFVFPPYL 190
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
283-572 |
3.21e-31 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 122.67 E-value: 3.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 283 PHQIGGIRFLYdnlveSLERYktssGFGCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLWLP 362
Cdd:cd18012 7 PYQKEGFNWLS-----FLRHY----GLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 363 aaealppdtdpqqvlprTFKVHILNDehkttVARAKVVEDWTGDGGVLLMGYEMYRllslkksfvtgrkrkskkpagpvi 442
Cdd:cd18012 78 -----------------ELKVLVIHG-----TKRKREKLRALEDYDLVITSYGLLR------------------------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 443 idldeedRQQELMKAIERalsrpgpDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPD 522
Cdd:cd18012 112 -------RDIELLKEVKF-------HYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPG 177
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 189535029 523 FLGTRQEFSNMFERPILNGQCIDSTPQdvqlmryrshvLHSLLEGFVQRR 572
Cdd:cd18012 178 LLGSYKRFKKRFAKPIEKDGDEEALEE-----------LKKLISPFILRR 216
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
312-572 |
1.13e-30 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 121.27 E-value: 1.13e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 312 ILAHSMGLGKTLQVISFIDVLLRHTG-AKTVLAIVPVNTLQNWLAEFNLWLPaaealppdtdpqqvLPRTFKVHILNDEH 390
Cdd:cd17997 26 ILADEMGLGKTLQTISLLGYLKHYKNiNGPHLIIVPKSTLDNWMREFKRWCP--------------SLRVVVLIGDKEER 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 391 KTTVARAKVVEDWTgdggVLLMGYEMyrllslkksfvtgrkrkskkpagpVIIDldeedrqqelmkaiERALSRPGPDVV 470
Cdd:cd17997 92 ADIIRDVLLPGKFD----VCITSYEM------------------------VIKE--------------KTVLKKFNWRYI 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 471 ICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFErpilNGQCIDSTPQD 550
Cdd:cd17997 130 IIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN----VNNCDDDNQEV 205
|
250 260
....*....|....*....|..
gi 189535029 551 VQLmryrshvLHSLLEGFVQRR 572
Cdd:cd17997 206 VQR-------LHKVLRPFLLRR 220
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
282-572 |
3.66e-30 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 120.18 E-value: 3.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGI---RFLYDNlvesleryktssGFGCILAHSMGLGKTLQVISFIdVLLRHTGAK-TVLAIVPVNTLQNWLAEF 357
Cdd:cd18009 5 RPYQLEGMewlRMLWEN------------GINGILADEMGLGKTIQTIALL-AHLRERGVWgPFLVIAPLSTLPNWVNEF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 358 NLWLPAAEALppdtdpqqvlprtfKVHILNDEHKTTVARAKVVEDWTGDGGVLLMGYEMYRllslkksfvtgrkrkskkp 437
Cdd:cd18009 72 ARFTPSVPVL--------------LYHGTKEERERLRKKIMKREGTLQDFPVVVTSYEIAM------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 438 agpviidldeEDRQqelmkaierALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 517
Cdd:cd18009 119 ----------RDRK---------ALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLN 179
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 189535029 518 FVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRYRSHVLHSLLEGFVQRR 572
Cdd:cd18009 180 FLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLRR 234
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
282-572 |
2.77e-28 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 114.77 E-value: 2.77e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRF---LYDNLVESleryktssgfgcILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAEF 357
Cdd:cd17996 5 KEYQLKGLQWmvsLYNNNLNG------------ILADEMGLGKTIQTISLITYLMEKKKNNgPYLVIVPLSTLSNWVSEF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 358 NLWLPaaealppdtdpqqvlprtfKVHILNDEHKTTVARAKVVEDWTGDGGVLLMGYEmYRLlslkksfvtgrKRKSKkp 437
Cdd:cd17996 73 EKWAP-------------------SVSKIVYKGTPDVRKKLQSQIRAGKFNVLLTTYE-YII-----------KDKPL-- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 438 agpviidldeedrqqelmkaieraLSRPGPDVVICDEGHRIKNCHASTSQALKN-IRSRRRVVLTGYPLQNNLIEYWCMV 516
Cdd:cd17996 120 ------------------------LSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLTGTPLQNNLPELWALL 175
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 189535029 517 DFVRPDFLGTRQEFSNMFERPILN--GQCIDSTPQDVQLMRYRShvLHSLLEGFVQRR 572
Cdd:cd17996 176 NFLLPKIFKSCKTFEQWFNTPFANtgEQVKIELNEEETLLIIRR--LHKVLRPFLLRR 231
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
282-521 |
3.36e-26 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 107.09 E-value: 3.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRFLydNLVeslerYKtsSGFGCILAHSMGLGKTLQVISFIDVLLR--HTGAKtvLAIVPVNTLQNWLAEFNL 359
Cdd:cd17998 2 KDYQLIGLNWL--NLL-----YQ--KKLSGILADEMGLGKTIQVIAFLAYLKEigIPGPH--LVVVPSSTLDNWLREFKR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 360 WLPAAEALPPDTDPQQvlprtfKVHILNDEHKTtvarakvVEDWTgdggVLLMGYEMyrllslkksfVTGRKrkskkpag 439
Cdd:cd17998 71 WCPSLKVEPYYGSQEE------RKHLRYDILKG-------LEDFD----VIVTTYNL----------ATSNP-------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 440 pviidldeEDRqqelmkaieRALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFV 519
Cdd:cd17998 116 --------DDR---------SFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFI 178
|
..
gi 189535029 520 RP 521
Cdd:cd17998 179 MP 180
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
310-534 |
4.61e-23 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 99.24 E-value: 4.61e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 310 GCILAHSMGLGKTLQVISFIDVLlRHTGAK--TVLAIVPVNTLQNWLAEFNLWlpaaealppdtdpqqvlprtfkvhiln 387
Cdd:cd17995 21 NCILADEMGLGKTIQSIAFLEHL-YQVEGIrgPFLVIAPLSTIPNWQREFETW--------------------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 388 dehktTVARAKVVEDwTGDGGVLLMGYEMYrllslkksFVTGRKRKSKKPAGPVIIDLDEEDrqqeLMKAIErALSRPGP 467
Cdd:cd17995 73 -----TDMNVVVYHG-SGESRQIIQQYEMY--------FKDAQGRKKKGVYKFDVLITTYEM----VIADAE-ELRKIPW 133
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189535029 468 DVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 534
Cdd:cd17995 134 RVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF 200
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
312-572 |
8.18e-22 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 95.50 E-value: 8.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 312 ILAHSMGLGKTLQVISfidvLLRHTGA-KTV----LAIVPVNTLQNWLAEFNLWLPAaealppdtdpqqvlprtFKVHIL 386
Cdd:cd18003 23 ILADEMGLGKTIQTIA----LLAHLACeKGNwgphLIVVPTSVMLNWEMEFKRWCPG-----------------FKILTY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 387 NDEHKTtvaRAKVVEDWTGDGG--VLLMGYEMyrLLSLKKSFvtgrKRKSKKpagpviidldeedrqqelmkaieralsr 464
Cdd:cd18003 82 YGSAKE---RKLKRQGWMKPNSfhVCITSYQL--VVQDHQVF----KRKKWK---------------------------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 465 pgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPiLNGQCI 544
Cdd:cd18003 125 ----YLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNP-LTAMSE 199
|
250 260
....*....|....*....|....*...
gi 189535029 545 DSTPQDVQLMRYrshvLHSLLEGFVQRR 572
Cdd:cd18003 200 GSQEENEELVRR----LHKVLRPFLLRR 223
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
307-585 |
1.80e-20 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 92.42 E-value: 1.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 307 SGFGCILAHSMGLGKTLQVISFIDVLLRH---TGAKTVLaiVPVNTLQNWLAEFNLWLPAAEALPPDTDPQQvlprtfkv 383
Cdd:cd18064 33 NGINGILADEMGLGKTLQTISLLGYMKHYrniPGPHMVL--VPKSTLHNWMAEFKRWVPTLRAVCLIGDKDQ-------- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 384 hilndehkttvaRAKVVED--WTGDGGVLLMGYEMyrLLSLKKSFVTGRKRkskkpagpviidldeedrqqelmkaiera 461
Cdd:cd18064 103 ------------RAAFVRDvlLPGEWDVCVTSYEM--LIKEKSVFKKFNWR----------------------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 462 lsrpgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFErpilNG 541
Cdd:cd18064 140 -------YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD----TN 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 189535029 542 QCIDstpqDVQLMRYrshvLHSLLEGFVQRRGHDVLRHQLPPKE 585
Cdd:cd18064 209 NCLG----DQKLVER----LHMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
312-572 |
2.58e-20 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 92.05 E-value: 2.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 312 ILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAEFNLWLPAAEALPPDTDPqqvlprtfkvhilndeh 390
Cdd:cd18063 46 ILADEMGLGKTIQTIALITYLMEHKRLNgPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTP----------------- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 391 ktTVARAKVVEDWTGDGGVLLMGYEMyrllslkksfvtgrkrkskkpagpVIIDldeedrqqelmkaiERALSRPGPDVV 470
Cdd:cd18063 109 --AMRRSLVPQLRSGKFNVLLTTYEY------------------------IIKD--------------KHILAKIRWKYM 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 471 ICDEGHRIKNCHASTSQALK-NIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPI-LNGQCIDSTP 548
Cdd:cd18063 149 IVDEGHRMKNHHCKLTQVLNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGERVDLNE 228
|
250 260
....*....|....*....|....
gi 189535029 549 QDVQLMRYRshvLHSLLEGFVQRR 572
Cdd:cd18063 229 EETILIIRR---LHKVLRPFLLRR 249
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
309-572 |
2.83e-20 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 91.58 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 309 FGCILAHSMGLGKTLQVISFI------------------DVLLRHTGAKTVLAIVPVNTLQNWLAEFNlwlpaaealppd 370
Cdd:cd18008 15 RGGILADEMGLGKTIQALALIlatrpqdpkipeeleensSDPKKLYLSKTTLIVVPLSLLSQWKDEIE------------ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 371 tdpQQVLPRTFKVHILndeHKTTvaRAKVVEDWTG-DggVLLMGYEMyrllsLKKSFvtgrkRKSKKPAGpviidLDEED 449
Cdd:cd18008 83 ---KHTKPGSLKVYVY---HGSK--RIKSIEELSDyD--IVITTYGT-----LASEF-----PKNKKGGG-----RDSKE 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 450 RQQELMKAIE--RalsrpgpdvVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTR 527
Cdd:cd18008 138 KEASPLHRIRwyR---------VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDY 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 189535029 528 QEFSNMFERPILNGQcidstpqdvqlmRYRSHVLHSLLEGFVQRR 572
Cdd:cd18008 209 PWFNSDISKPFSKND------------RKALERLQALLKPILLRR 241
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
721-851 |
3.37e-20 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 87.27 E-value: 3.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 721 AKMVLLFYLIDEtvARGDKILVFSQSLSTLTviEDFLSRRpmpiqtetgthnwvRNINYYRLDGSTSASERERLINQFND 800
Cdd:pfam00271 1 EKLEALLELLKK--ERGGKVLIFSQTKKTLE--AELLLEK--------------EGIKVARLHGDLSQEEREEILEDFRK 62
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 189535029 801 PANTqawvFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYG 851
Cdd:pfam00271 63 GKID----VLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
281-572 |
3.72e-20 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 91.64 E-value: 3.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFL---YDNlvesleryktssGFGCILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAE 356
Cdd:cd18062 24 LKQYQIKGLEWLvslYNN------------NLNGILADEMGLGKTIQTIALITYLMEHKRINgPFLIIVPLSTLSNWVYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 357 FNLWLPAAEALPPDTDPqqvlprtfkvhilndehktTVARAKVVEDWTGDGGVLLMGYEMyrllslkksfvtgrkrkskk 436
Cdd:cd18062 92 FDKWAPSVVKVSYKGSP-------------------AARRAFVPQLRSGKFNVLLTTYEY-------------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 437 pagpVIIDldeedrqqelmkaiERALSRPGPDVVICDEGHRIKNCHASTSQALK-NIRSRRRVVLTGYPLQNNLIEYWCM 515
Cdd:cd18062 133 ----IIKD--------------KQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNtHYVAPRRLLLTGTPLQNKLPELWAL 194
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 189535029 516 VDFVRPDFLGTRQEFSNMFERPI-LNGQCIDSTPQDVQLMRYRshvLHSLLEGFVQRR 572
Cdd:cd18062 195 LNFLLPTIFKSCSTFEQWFNAPFaMTGEKVDLNEEETILIIRR---LHKVLRPFLLRR 249
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
282-546 |
1.28e-19 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 89.33 E-value: 1.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRFLydnlvESLERYKTSSgfgcILAHSMGLGKTLQVISFI--DVLLRHTGAKT----VLAIVPVNTLQNWLA 355
Cdd:cd17999 2 RPYQQEGINWL-----AFLNKYNLHG----ILCDDMGLGKTLQTLCILasDHHKRANSFNSenlpSLVVCPPTLVGHWVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 356 EFNLWLPaaealppdtdpQQVLprtfKVHILndeHKTTVARAKVVEDwTGDGGVLLMGYEMYRLLS---LKKSFvtgrkr 432
Cdd:cd17999 73 EIKKYFP-----------NAFL----KPLAY---VGPPQERRRLREQ-GEKHNVIVASYDVLRNDIevlTKIEW------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 433 kskkpagpviidldeedrqqelmkaieralsrpgpDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEY 512
Cdd:cd17999 128 -----------------------------------NYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLEL 172
|
250 260 270
....*....|....*....|....*....|....
gi 189535029 513 WCMVDFVRPDFLGTRQEFSNMFERPILngQCIDS 546
Cdd:cd17999 173 WSLFDFLMPGYLGTEKQFQRRFLKPIL--ASRDS 204
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
283-535 |
6.44e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 86.34 E-value: 6.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 283 PHQIGGIRFLydnlvesleRYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAEFNLWL 361
Cdd:cd17994 3 PYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEMWA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 362 PaaealppdtdpqqvlprtfkvhilnDEHKTTvarakvvedWTGDgGVLLMGYEMyrllslkksfvtgrkrkskkpagpV 441
Cdd:cd17994 74 P-------------------------DFYVVT---------YVGD-HVLLTSYEL------------------------I 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 442 IIDldeedrqQELMKAIERAlsrpgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRP 521
Cdd:cd17994 95 SID-------QAILGSIDWA-------VLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTP 160
|
250
....*....|....
gi 189535029 522 DFLGTRQEFSNMFE 535
Cdd:cd17994 161 ERFNNLQGFLEEFA 174
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
775-851 |
2.09e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 81.10 E-value: 2.09e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189535029 775 RNINYYRLDGSTSASERERLINQFNDPANtqawVFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYG 851
Cdd:smart00490 10 LGIKVARLHGGLSQEEREEILDKFNNGKI----KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
281-572 |
4.30e-18 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 84.86 E-value: 4.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLYdNLVESleryktssGFGCILAHSMGLGKTLQVISFIDVLLRHTGA-KTVLAIVPVNTLQNWLAEFNL 359
Cdd:cd18002 1 LKEYQLKGLNWLA-NLYEQ--------GINGILADEMGLGKTVQSIAVLAHLAEEHNIwGPFLVIAPASTLHNWQQEISR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 360 WLPAAEALPPDTDPQQvlpRTFKVHILNDEHKTTvarakvvedwtGDGG--VLLMGYEMyrllslkksfvtgrkrkskkp 437
Cdd:cd18002 72 FVPQFKVLPYWGNPKD---RKVLRKFWDRKNLYT-----------RDAPfhVVITSYQL--------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 438 agpVIIDldeedrqqelmkaiERALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 517
Cdd:cd18002 117 ---VVQD--------------EKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLH 179
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 189535029 518 FVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVQLMRyrshvLHSLLEGFVQRR 572
Cdd:cd18002 180 FIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQLKR-----LHMILKPFMLRR 229
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
311-572 |
6.91e-18 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 83.94 E-value: 6.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 311 CILAHSMGLGKTLQVISFIDVLL-RHTGAKTVLAIVPVNTLQNWLAEFNLWLPAaealppdtdpqqvlprtfkvhiLNde 389
Cdd:cd17993 23 GILADEMGLGKTVQTISFLSYLFhSQQQYGPFLVVVPLSTMPAWQREFAKWAPD----------------------MN-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 390 hkttvarakvVEDWTGDGGV--LLMGYEMYrllslkksfvTGRKRKSKKPAGPVIIDLDEEDRQQelmkaieraLSRPGP 467
Cdd:cd17993 79 ----------VIVYLGDIKSrdTIREYEFY----------FSQTKKLKFNVLLTTYEIILKDKAF---------LGSIKW 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 468 DVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFsnmferpilngqciDST 547
Cdd:cd17993 130 QYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEF--------------EEE 195
|
250 260
....*....|....*....|....*
gi 189535029 548 PQDVQLMRYRShvLHSLLEGFVQRR 572
Cdd:cd17993 196 HDEEQEKGIAD--LHKELEPFILRR 218
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
312-572 |
7.29e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 84.67 E-value: 7.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 312 ILAHSMGLGKTLQVISFIDVLL-RHTGAKTVLAIVPVNTLQNWLAEFNLWLPAAEALppdtdpqqvlprtfkVHILNDEH 390
Cdd:cd18054 43 ILADEMGLGKTIQTISFLSYLFhQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVV---------------VYIGDLMS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 391 KTTVARAKVVEDWTG--DGGVLLMGYEMYrllsLKKSFVTGrkrkskkpagpviidldeedrqqelmkAIERALsrpgpd 468
Cdd:cd18054 108 RNTIREYEWIHSQTKrlKFNALITTYEIL----LKDKTVLG---------------------------SINWAF------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 469 vVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGqcidstp 548
Cdd:cd18054 151 -LGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENG------- 222
|
250 260
....*....|....*....|....
gi 189535029 549 qdvqlmrYRShvLHSLLEGFVQRR 572
Cdd:cd18054 223 -------YQS--LHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
307-572 |
1.00e-17 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 83.91 E-value: 1.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 307 SGFGCILAHSMGLGKTLQVISFIDVLLRH---TGAKTVLaiVPVNTLQNWLAEFNLWLPAAEAlppdtdpqqvlprtfkV 383
Cdd:cd18065 33 NGVNGILADEMGLGKTLQTIALLGYLKHYrniPGPHMVL--VPKSTLHNWMNEFKRWVPSLRA----------------V 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 384 HILNDEHkttvARAKVVED--WTGDGGVLLMGYEMyrLLSLKKSFVTGRKRkskkpagpviidldeedrqqelmkaiera 461
Cdd:cd18065 95 CLIGDKD----ARAAFIRDvmMPGEWDVCVTSYEM--VIKEKSVFKKFNWR----------------------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 462 lsrpgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFErpilNG 541
Cdd:cd18065 140 -------YLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD----TK 208
|
250 260 270
....*....|....*....|....*....|.
gi 189535029 542 QCIDstpqDVQLMRYrshvLHSLLEGFVQRR 572
Cdd:cd18065 209 NCLG----DQKLVER----LHAVLKPFLLRR 231
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
281-572 |
1.13e-16 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 80.56 E-value: 1.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLydnlvesLERYKTssGFGCILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAEFNL 359
Cdd:cd18006 1 LRPYQLEGVNWL-------LQCRAE--QHGCILGDEMGLGKTCQTISLLWYLAGRLKLLgPFLVLCPLSVLDNWKEELNR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 360 WLPAAEALPPDTDPQQVLPRTFKVHILNDEHkttvarakvvedwtgdggVLLMGYEMyrllslkksfvtgrkrkskkpag 439
Cdd:cd18006 72 FAPDLSVITYMGDKEKRLDLQQDIKSTNRFH------------------VLLTTYEI----------------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 440 pVIIDldeedrqQELMKAIERAlsrpgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFV 519
Cdd:cd18006 111 -CLKD-------ASFLKSFPWA-------SLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFI 175
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 189535029 520 RPDFLG--TRQEFSNMFERpilngqcIDSTPQDVQlmryrshVLHSLLEGFVQRR 572
Cdd:cd18006 176 EPNVFPkdKLDDFIKAYSE-------TDDESETVE-------ELHLLLQPFLLRR 216
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
281-534 |
1.55e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 74.72 E-value: 1.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLydnlvesleRYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAEFNL 359
Cdd:cd18057 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKgPYLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 360 WlpaaealppdtdpqqvLPRTFKVHILNDEHKTTVARAKvveDWTGDGGVLLMGYEMYRLlslkksfvtgrKRKSKKPAG 439
Cdd:cd18057 72 W----------------APDFYVVTYTGDKESRSVIREN---EFSFEDNAIRSGKKVFRM-----------KKEAQIKFH 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 440 PVIIDLDEEDRQQELMKAIERAlsrpgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFV 519
Cdd:cd18057 122 VLLTSYELITIDQAILGSIEWA-------CLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFL 194
|
250
....*....|....*
gi 189535029 520 RPDFLGTRQEFSNMF 534
Cdd:cd18057 195 TPERFNNLEGFLEEF 209
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
307-541 |
2.24e-14 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 74.43 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 307 SGFGCILAHSMGLGKTLQVISFIdvllrhtGAKTVLAIVPVNTLQNWLAEFNlwlpaaealppdtdpQQVLPRTFKVHIL 386
Cdd:cd18071 47 LVRGGILADDMGLGKTLTTISLI-------LANFTLIVCPLSVLSNWETQFE---------------EHVKPGQLKVYTY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 387 NDEHKTTVARakvvedwtgdggvLLMGYEM----YRLLSLKKSfvtgrkrksKKPAGPViidldeedrqqelmKAIE--R 460
Cdd:cd18071 105 HGGERNRDPK-------------LLSKYDIvlttYNTLASDFG---------AKGDSPL--------------HTINwlR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 461 alsrpgpdvVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILN 540
Cdd:cd18071 149 ---------VVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTM 219
|
.
gi 189535029 541 G 541
Cdd:cd18071 220 G 220
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
282-530 |
1.57e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 72.00 E-value: 1.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRFL--YDNLVESLERYKTS--SGFGCILAHSMGLGKTLQVISFIDVLL-RHTGAKTVLAIVPVNTLQNWLAE 356
Cdd:cd18053 9 QPSYIGGHEGLelRDYQLNGLNWLAHSwcKGNSCILADEMGLGKTIQTISFLNYLFhEHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 357 FNLWLPAAEALP--PDTDPQQVLPRTFKVHilndehkTTVARAKVvedwtgdgGVLLMGYEmyrLLSLKKSFVTGrkrks 434
Cdd:cd18053 89 IQTWAPQMNAVVylGDINSRNMIRTHEWMH-------PQTKRLKF--------NILLTTYE---ILLKDKSFLGG----- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 435 kkpagpviidldeedrqqelmkaIERALsrpgpdvVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWC 514
Cdd:cd18053 146 -----------------------LNWAF-------IGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWS 195
|
250
....*....|....*.
gi 189535029 515 MVDFVRPDFLGTRQEF 530
Cdd:cd18053 196 LLHFIMPEKFSSWEDF 211
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
302-533 |
5.13e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 70.04 E-value: 5.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 302 RYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAEFNLWLPAAEAL--PPDTDPQQVLP 378
Cdd:cd18055 13 RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKgPFLVSAPLSTIINWEREFQMWAPDFYVVtyTGDKDSRAIIR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 379 R---TFKVHILNDEHKTTVARAKVVEDWTgdggVLLMGYEMyrllslkksfvtgrkrkskkpagpVIIDldeedrqQELM 455
Cdd:cd18055 93 EnefSFDDNAVKGGKKAFKMKREAQVKFH----VLLTSYEL------------------------VTID-------QAAL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 456 KAIERAlsrpgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFL----GTRQEFS 531
Cdd:cd18055 138 GSIRWA-------CLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFnnleGFLEEFA 210
|
..
gi 189535029 532 NM 533
Cdd:cd18055 211 DI 212
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
311-534 |
1.20e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 68.93 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 311 CILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLWlpaaealppdTDPQQVLprtfkvhilndEH 390
Cdd:cd18060 22 CILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTW----------TEMNTIV-----------YH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 391 KTTVARAkvvedwtgdggvLLMGYEMYrllslkksfvtgrkrkSKKPAGPVIIDLDEEDrqqELMKAIERALSrPGPDV- 469
Cdd:cd18060 81 GSLASRQ------------MIQQYEMY----------------CKDSRGRLIPGAYKFD---ALITTFEMILS-DCPELr 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189535029 470 ------VICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 534
Cdd:cd18060 129 eiewrcVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF 199
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
281-533 |
1.24e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 68.94 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLydnlvesleRYKTSSGFGCILAHSMGLGKTLQVISFIDVLLRHTGAK-TVLAIVPVNTLQNWLAEFNL 359
Cdd:cd18056 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 360 WLPAAEALP--PDTDPQQVLpRTFKVHILNDEHKTTVARAKVVEDWTGDGGVLLMGYEMyrllslkksfvtgrkrkskkp 437
Cdd:cd18056 72 WAPDMYVVTyvGDKDSRAII-RENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYEL--------------------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 438 agpVIIDLdeedrqqELMKAIERAlsrpgpdVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVD 517
Cdd:cd18056 130 ---ITIDM-------AILGSIDWA-------CLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLN 192
|
250 260
....*....|....*....|
gi 189535029 518 FVRPDFL----GTRQEFSNM 533
Cdd:cd18056 193 FLTPERFhnleGFLEEFADI 212
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
311-534 |
1.73e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 68.53 E-value: 1.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 311 CILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLWlpaaealppdTDPQQVLprtfkvhilndEH 390
Cdd:cd18058 22 CILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTW----------TEMNAIV-----------YH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 391 KTTVARAkvvedwtgdggvLLMGYEMYRllslkksfvtgrkRKSKKPAGPVIIDLDEEDRQQELMKAIERALSRPGPDVV 470
Cdd:cd18058 81 GSQISRQ------------MIQQYEMYY-------------RDEQGNPLSGIFKFQVVITTFEMILADCPELKKINWSCV 135
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189535029 471 ICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 534
Cdd:cd18058 136 IIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF 199
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
311-534 |
3.57e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 67.34 E-value: 3.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 311 CILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLWlpaaealppdTDPQQVLprtfkvhilndEH 390
Cdd:cd18061 22 CILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTW----------TDLNVVV-----------YH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 391 KTTVARAkvvedwtgdggvLLMGYEMYrllslkksfvtgrkrkSKKPAGPVIidlDEEDRQQELMKAIERALSRPGP--- 467
Cdd:cd18061 81 GSLISRQ------------MIQQYEMY----------------FRDSQGRII---RGAYRFQAIITTFEMILGGCPElna 129
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 468 ---DVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 534
Cdd:cd18061 130 idwRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF 199
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
282-530 |
1.43e-11 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 65.30 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRFlydnlveSLERyktssGFGCILAHSMGLGKTLQVISFIDVLlRHTGAktVLAIVPVNTLQNWLAEFNLWL 361
Cdd:cd18010 2 LPFQREGVCF-------ALRR-----GGRVLIADEMGLGKTVQAIAIAAYY-REEWP--LLIVCPSSLRLTWADEIERWL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 362 PaaEALPPDtdpqqvlprtfkVHILNDEHkttvarakvvEDW-TGDGGVLLMGYEMYRLLSLKKSfvtgrKRKSKkpagp 440
Cdd:cd18010 67 P--SLPPDD------------IQVIVKSK----------DGLrDGDAKVVIVSYDLLRRLEKQLL-----ARKFK----- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 441 viidldeedrqqelmkaieralsrpgpdVVICDEGHRIKNCHASTSQALKNI--RSRRRVVLTGYPLQNNLIEYWCMVDF 518
Cdd:cd18010 113 ----------------------------VVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDA 164
|
250
....*....|..
gi 189535029 519 VRPDFLGTRQEF 530
Cdd:cd18010 165 LDPKLFGRFHDF 176
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
281-534 |
3.52e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 64.67 E-value: 3.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 281 VKPHQIGGIRFLYDNLveslerYKTSSgfgCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAEFNLW 360
Cdd:cd18059 1 LREYQLEGVNWLLFNW------YNTRN---CILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 361 lpaaealppdTDPQQVLprtfkvhilndEHKTTVARAKVvedwtgdggvllMGYEMYrllslkksfvtgrkrkSKKPAGP 440
Cdd:cd18059 72 ----------TELNVVV-----------YHGSQASRRTI------------QLYEMY----------------FKDPQGR 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 441 VIidlDEEDRQQELMKAIERALS-----RPGP-DVVICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWC 514
Cdd:cd18059 103 VI---KGSYKFHAIITTFEMILTdcpelRNIPwRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFS 179
|
250 260
....*....|....*....|
gi 189535029 515 MVDFVRPDFLGTRQEFSNMF 534
Cdd:cd18059 180 LLHFLEPSRFPSETTFMQEF 199
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
283-524 |
1.08e-10 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 62.51 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 283 PHQIGGIRFLYDNLvesleryktssgFGCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTL-QNWLAEFNLWL 361
Cdd:smart00487 11 PYQKEAIEALLSGL------------RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKLG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 362 PaaealppdtdpqqvlPRTFKVHILNDEHKTTVARAKVVEdwtGDGGVLLMGYEmyRLLSLKKsfvtgrkrkskkpagpv 441
Cdd:smart00487 79 P---------------SLGLKVVGLYGGDSKREQLRKLES---GKTDILVTTPG--RLLDLLE----------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 442 iidldeedrqqelmkaiERALSRPGPDVVICDEGHRIKNchASTSQALKNI-----RSRRRVVLTGYP---LQNNLIEYW 513
Cdd:smart00487 122 -----------------NDKLSLSNVDLVILDEAHRLLD--GGFGDQLEKLlkllpKNVQLLLLSATPpeeIENLLELFL 182
|
250
....*....|.
gi 189535029 514 CMVDFVRPDFL 524
Cdd:smart00487 183 NDPVFIDVGFT 193
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
283-536 |
3.80e-09 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 58.07 E-value: 3.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 283 PHQIGGIRFLYDNLVesleryktssgFGCILAHSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQNWLAE----FN 358
Cdd:cd18011 3 PHQIDAVLRALRKPP-----------VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDElqdkFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 359 LwlpaaealppdtdpQQVLPRTFKVHILNDEHKTTVARAKVvedwtgdggvllmgyemyrllslkksfvtgrkrkskkpa 438
Cdd:cd18011 72 L--------------PFLILDRETAAQLRRLIGNPFEEFPI--------------------------------------- 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 439 gpVIIDLDEEDRQQELmkaiERALSRPGPDVVICDEGHRIKNCHASTSQ----ALKNI--RSRRRVVLTGYPLQNNLIEY 512
Cdd:cd18011 99 --VIVSLDLLKRSEER----RGLLLSEEWDLVVVDEAHKLRNSGGGKETkrykLGRLLakRARHVLLLTATPHNGKEEDF 172
|
250 260 270
....*....|....*....|....*....|....
gi 189535029 513 WCMVDFVRPDF----------LGTRQEFSNMFER 536
Cdd:cd18011 173 RALLSLLDPGRfavlgrflrlDGLREVLAKVLLR 206
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
470-520 |
3.07e-06 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 50.17 E-value: 3.07e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 189535029 470 VICDEGHRIKNCHASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVR 520
Cdd:cd18072 155 IILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
282-519 |
5.90e-04 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 43.11 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 282 KPHQIGGIRFLYDNLVesleryktssgfGCILAhSMGLGKTLQVISFIDVLLRHTGAKTVLAIVPVNTLQN-WLAEFNLW 360
Cdd:cd18013 2 HPYQKVAINFIIEHPY------------CGLFL-DMGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKW 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 361 lpaaealppdtdpqqvlprtfkvhilndEHkttvarakvvedwtgdggvllmgyemyrLLSLKKSFVTGRKRK----SKK 436
Cdd:cd18013 69 ----------------------------NH----------------------------LRNLTVSVAVGTERQrskaANT 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 437 PAGPVIIDLDEEDrqqelmKAIERALSRPGPDVVICDEGHRIKNCHASTSQALKNIRSR--RRVVLTGYPLQNNLIEYWC 514
Cdd:cd18013 93 PADLYVINRENLK------WLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVikRLIGLTGTPSPNGLMDLWA 166
|
....*
gi 189535029 515 MVDFV 519
Cdd:cd18013 167 QIALL 171
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
911-1161 |
1.32e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 43.52 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 911 PDPAELQPNNEMET----VIQQACVMYPHLLTKPPFHHESllmdrkemkltkAEKRAAKKSYEDEKRASVPYqRPSYAHY 986
Cdd:PHA03378 569 LGPLQIQPLTSPTTsqlaSSAPSYAQTPWPVPHPSQTPEP------------PTTQSHIPETSAPRQWPMPL-RPIPMRP 635
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 987 ------------YPASDQRLTNIPAFSQRNWRPPPHLEEKPV----ASVRPVQSTPIPMMPrqvPMGVPSsstgfPVNYL 1050
Cdd:PHA03378 636 lrmqpitfnvlvFPTPHQPPQVEITPYKPTWTQIGHIPYQPSptgaNTMLPIQWAPGTMQP---PPRAPT-----PMRPP 707
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 1051 QKAGVYVQRVVTTTDIVIPGSNSSTDVQARIGAgesihvirgskgtyirTNDGRIFAIRSGKPRPPEGGATASREDCGPP 1130
Cdd:PHA03378 708 AAPPGRAQRPAAATGRARPPAAAPGRARPPAAA----------------PGRARPPAAAPGRARPPAAAPGRARPPAAAP 771
|
250 260 270
....*....|....*....|....*....|.
gi 189535029 1131 lhsvsnGRASPQEPKRLTPEALPRPSSRESP 1161
Cdd:PHA03378 772 ------GAPTPQPPPQAPPAPQQRPRGAPTP 796
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
718-798 |
6.94e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 38.77 E-value: 6.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189535029 718 ENSAKMVLLFYLIDETvARGDKILVFSQSLSTLTVIedflSRRpmpiqtetgthnwvrnINYYRLDGSTSASERERLINQ 797
Cdd:cd18789 31 MNPNKLRALEELLKRH-EQGDKIIVFTDNVEALYRY----AKR----------------LLKPFITGETPQSEREEILQN 89
|
.
gi 189535029 798 F 798
Cdd:cd18789 90 F 90
|
|
| |
