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Conserved domains on  [gi|221143479|ref|YP_002519493|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Scarus forsteni]

Protein Classification

NADH-ubiquinone oxidoreductase subunit 4L( domain architecture ID 10009576)

NADH-ubiquinone oxidoreductase subunit 4L (ND4L) is core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.48e-52

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177185  Cd Length: 98  Bit Score: 158.97  E-value: 2.48e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 221143479 81 TSRTHGSDRLKNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.48e-52

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 158.97  E-value: 2.48e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 221143479 81 TSRTHGSDRLKNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 2.31e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 65.28  E-value: 2.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479   3 PIHFAFTTAFALGLTGLAFQRtHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVATS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 221143479  83 RTHGSDRLKNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 4.13e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 38.89  E-value: 4.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479 12 FALGLTGLAFQRtHLLSALLCLEGMMLS---LYIALSLWTLQLDSSGFSpapMILLAFSACEASAGLALLVATSRTHGSD 88
Cdd:COG0713  14 FAIGLYGVLTRR-NLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGLAIIVALYRNRGTI 89


                ....*...
gi 221143479 89 RLKNLNLL 96
Cdd:COG0713  90 DVDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.48e-52

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 158.97  E-value: 2.48e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 221143479 81 TSRTHGSDRLKNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.91e-40

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 128.81  E-value: 1.91e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 221143479 81 TSRTHGSDRLKNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.53e-40

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 127.41  E-value: 6.53e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 221143479 81 TSRTHGSDRLKNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.30e-27

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 96.15  E-value: 1.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 221143479 81 TSRTHGSDRLKNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-96 7.01e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 84.23  E-value: 7.01e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  4 IHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVATSR 83
Cdd:MTH00181  1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                        90
                ....*....|...
gi 221143479 84 THGSDRLKNLNLL 96
Cdd:MTH00181 81 THGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.90e-20

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 78.04  E-value: 1.90e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 221143479 81 TSRTHGSDRLKNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 2.31e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 65.28  E-value: 2.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479   3 PIHFAFTTAFALGLTGLAFQRtHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVATS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 221143479  83 RTHGSDRLKNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 12-98 2.43e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 59.99  E-value: 2.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479 12 FALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPapMILLAFSACEASAGLALLVATSRTHGSDRLK 91
Cdd:MTH00188 13 VVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLS--LVLLTFAACEASVGLALLVSLIRSHGSDYVS 90


                ....*..
gi 221143479 92 NLNLLQC 98
Cdd:MTH00188 91 SLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 5.45e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 59.09  E-value: 5.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIAL-SLWTLQLDSSGFSpapMILLAFSACEASAGLALLV 79
Cdd:MTH00149  2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMfSSSGLISFSSYLF---LIILTFGACEASLGLSLLV 78

                        90
                ....*....|....*....
gi 221143479 80 ATSRTHGSDRLKNLNLLQC 98
Cdd:MTH00149 79 SLIRLHGNDYVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 4.32e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 51.31  E-value: 4.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479 12 FALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPapMILLAFSACEASAGLALLVATSRTHGSDRLK 91
Cdd:MTH00162 11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFL--LFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                .
gi 221143479 92 N 92
Cdd:MTH00162 89 S 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 8.84e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 48.21  E-value: 8.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479  1 MMPIHFAFTTAFALGLTGLAFQRTHLLSALLCLEGMMLSLYIaLSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVA 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLAL-FIPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 221143479 81 TSRTHGSDRLKNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 1.28e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 45.41  E-value: 1.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479 12 FALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVATSRTHGSDRLK 91
Cdd:MTH00180 13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                ....*.
gi 221143479 92 NLNLLQ 97
Cdd:MTH00180 93 SLNLLR 98
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 4.13e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 38.89  E-value: 4.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479 12 FALGLTGLAFQRtHLLSALLCLEGMMLS---LYIALSLWTLQLDSSGFSpapMILLAFSACEASAGLALLVATSRTHGSD 88
Cdd:COG0713  14 FAIGLYGVLTRR-NLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGLAIIVALYRNRGTI 89


                ....*...
gi 221143479 89 RLKNLNLL 96
Cdd:COG0713  90 DVDDLNEL 97
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 31-98 9.44e-05

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 39.55  E-value: 9.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221143479  31 LCLEGMMLSLYIALSLWTLQLDSSGfspapmillafSACEASAGLALLVATSRTHGSDRLKNLNLLQC 98
Cdd:MTH00127 376 LMGELMIITSLFNWSPWTLALTGLG-----------TLITAGYSLYMFLMTQRGPLPDHIIALNPSHT 432
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
1-96 2.78e-04

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 36.69  E-value: 2.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479   1 MMPI-HFAFTTA--FALGLTGLaFQRTHLLSALLCLEGMMLSLYIAL---SLWTLQLDSSGFSpapMILLAFSACEASAG 74
Cdd:PRK05715   1 MIPLqHYLILAAilFCIGLVGL-LLRRNAIVVLMSIELMLNAVNLNFvafSSYLGDLDGQVFA---FFVITVAAAEAAIG 76

                         90       100
                 ....*....|....*....|..
gi 221143479  75 LALLVATSRTHGSDRLKNLNLL 96
Cdd:PRK05715  77 LAILLQLYRNRGTIDVDDLNEL 98
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 12-97 2.95e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 36.58  E-value: 2.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221143479 12 FALGLTGLAFQRTHLLSALLCLEGMMLSLYIALSLWTLQLDSSGFSPAPMILLAFSACEASAGLALLVATSRTHGSDRLK 91
Cdd:MTH00001 13 FLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTISLK 92


                ....*.
gi 221143479 92 NLNLLQ 97
Cdd:MTH00001 93 SLNSLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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