NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|251831108|ref|YP_003024027|]
View 

NADH dehydrogenase subunit 2 (mitochondrion) [Homo sapiens]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 4.52e-163

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 458.93  E-value: 4.52e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*.
gi 251831108 321 KPTPFLPTLIALTTLLLPISPFMLMI 346
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSIL 346
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 4.52e-163

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 458.93  E-value: 4.52e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*.
gi 251831108 321 KPTPFLPTLIALTTLLLPISPFMLMI 346
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSIL 346
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-268 3.35e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.52  E-value: 3.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   23 SSHWFFTWVGLEMNMLAFIPVLT-KKMNPRSTEAAIKYFLTQATASMILLMAIL----------FNNMLSGQWTMTNTTN 91
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISlmynytgtlsFDELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   92 Q-YSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLT-SGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMA----- 164
Cdd:pfam00361  81 LlLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPvSALLAATLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIismll 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  165 GSWGGLNQTQLRKILAYSSITHMGWMMAVL----PYNPNMTILNLTIYIILTTTAFLL-LNLNSSTTTLLLSRTWNKLTW 239
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCaGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 251831108  240 LTPLIPSTLLSLGGLP----PLTGFLPKWAIIE 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLaglpPTAGFLGKFLILA 273
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 7-297 1.03e-17

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 83.84  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108    7 PVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAF-IPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWT 85
Cdd:TIGR01770 105 YILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   86 MTNTTNQYSSLM------------IMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISP------ 147
Cdd:TIGR01770 185 FEDLLLFLSNGMlnisllllgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLyilfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  148 SLNVSLLLTLSILSIMA-GSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILtttaFLLLNLNSSTT 226
Cdd:TIGR01770 265 SEAWQIFLAIIAFLSMLiGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFI----YALMSLGAFGV 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  227 TLLLSRT---WNK-------LTWLTPLIPSTLLSLGGLPP----LTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYF 292
Cdd:TIGR01770 341 LSLLRSYkdeWIEyisdfagLFKTNPILAILILIFMFSLAgippLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFY 420


                  ....*
gi 251831108  293 YLRLI 297
Cdd:TIGR01770 421 YLRVV 425
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 15-221 1.38e-17

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 83.24  E-value: 1.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  15 AGTLITALSSHWFFTWVGLEMNMLA-FIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSG-----QWTMTN 88
Cdd:COG1007  113 LGMMLMASANDLLTLFLGLELLSLSlYVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGslnlaGIAAAL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  89 TTNQYSSLMIMMAMAM-------KLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQI-SPSLNVSLLLTLSIL 160
Cdd:COG1007  193 AAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlVEAFPGLAADWQLLL 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251831108 161 SIMA------GSWGGLNQTQLRKILAYSSITHMGWMM-AVLPYNPNM---TILNLTIYIILTTTAFLLLNL 221
Cdd:COG1007  273 AVLAvlsmtvGNLAALAQTNVKRMLAYSSIAHAGYLLlGLAAGTPLGvsaALFYLLAYLFMNLGAFAVILL 343
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 4.52e-163

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 458.93  E-value: 4.52e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*.
gi 251831108 321 KPTPFLPTLIALTTLLLPISPFMLMI 346
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSIL 346
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-347 1.36e-105

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 313.30  E-value: 1.36e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL 160
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHT 320
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320

                        330       340
                 ....*....|....*....|....*..
gi 251831108 321 KPTPfLPTLIALTTLLLPISPFMLMIL 347
Cdd:MTH00112 321 KNTL-TATLTTLSTLLLPLSPMILTII 346
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-347 5.61e-102

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 304.03  E-value: 5.61e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSlNVSLLLTLSIL 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330       340
                 ....*....|....*....|....*..
gi 251831108 321 KPTPFLPTLIALTTLLLPISPFMLMIL 347
Cdd:MTH00135 320 QLTLPLAISTTATLMLLPLTPAILALL 346
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-347 1.76e-98

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 294.91  E-value: 1.76e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFeHT 320
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRF-KN 319

                        330       340
                 ....*....|....*....|....*..
gi 251831108 321 KPTPFLPTLIALTTLLLPISPFMLMIL 347
Cdd:MTH00070 320 KTNNLLSLTIILSLMLLPITPTILNLF 346
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-306 1.68e-78

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 244.07  E-value: 1.68e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL 160
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLP 306
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFP 306
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-347 2.62e-78

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 243.34  E-value: 2.62e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   1 MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  81 SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL 160
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 161 SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL 240
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 241 TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHT 320
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320

                        330       340
                 ....*....|....*....|....*..
gi 251831108 321 KpTPFLPTLIALTTLLLPISPFMLMIL 347
Cdd:MTH00200 321 S-NLLVGLLLLLSILGLPLTPQLLFLF 346
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 10-347 8.15e-51

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 171.93  E-value: 8.15e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  10 YSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMlsgqwtMTNT 89
Cdd:MTH00160  11 LSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML------NLML 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  90 TNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQIspsLNVSLLLTLSILSIMAGSWGG 169
Cdd:MTH00160  85 FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL---INNNFIIIIIILSAIIGAIGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 170 LNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLL 249
Cdd:MTH00160 162 LNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 250 SLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSitllpMSNNVKMKWQFEHTKPTPFLPTL 329
Cdd:MTH00160 242 SLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSL-----MLNYNKNKWNLKKKKNKFSLILN 316

                        330
                 ....*....|....*...
gi 251831108 330 IALTTLLLPISPFMLMIL 347
Cdd:MTH00160 317 FLSFISLFGLILSSLLFL 334
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 13-315 7.63e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 158.90  E-value: 7.63e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  13 IFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWtmtnttnq 92
Cdd:MTH00144  13 MVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSW-------- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  93 YSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIM-AGSWGGLN 171
Cdd:MTH00144  85 FSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVISVLSAlVGSIGGLN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 172 QTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTtaFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSL 251
Cdd:MTH00144 165 QTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSG--FLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLLLS 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 251831108 252 GG-LPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKW 315
Cdd:MTH00144 243 LGgLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 10-299 5.95e-45

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 156.48  E-value: 5.95e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  10 YSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAilfnnmLSGQWTMTNT 89
Cdd:MTH00011  12 SSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLG------MTMMWSFPSL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  90 TNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGG 169
Cdd:MTH00011  86 LKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGLGG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 170 LNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLN----LNSSTTTLLLSRTWNKLTWLTPLIP 245
Cdd:MTH00011 166 MNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAylnaFSTKFNSKISSMSQTTSMSLFIMLL 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 251831108 246 StllsLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYS 299
Cdd:MTH00011 246 S----LGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN 295
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-317 1.78e-37

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 136.73  E-value: 1.78e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   8 VIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLM---AILFNNMLSgqw 84
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMggsLSFSNLYLS--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  85 tmtnttnQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLnvSLLLTLSILSIMA 164
Cdd:MTH00197  79 -------LLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSF--MGLLICSVLSSLI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 165 GSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLI 244
Cdd:MTH00197 150 GGIGGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFL 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251831108 245 PSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQF 317
Cdd:MTH00197 230 GLSFLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLL 302
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 16-224 5.45e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 96.24  E-value: 5.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  16 GTLITALSSHWFFTWVGLEMNMLA-FIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSG----QWTMTNTT 90
Cdd:MTH00199 109 GSLLLVSSINWLSIYLAIELQTLTlFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGetsiQGINSILT 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  91 NQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVslLLTLSILSIMAGSWGGL 170
Cdd:MTH00199 189 GDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNV--VLICAVLSIIYGAIGAL 266

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 251831108 171 NQTQLRKILAYSSITHMGWMMAVLPYNPNMTI----LNLTIYIILTTTAF-LLLNLNSS 224
Cdd:MTH00199 267 NQTKIKRLLAYSGIGHMGFILFGVAIGSFESIqaslIYMIIYVIMSICSFsIILSLKLT 325
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-297 2.07e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 90.86  E-value: 2.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  16 GTLITALSSHWFFTWVGLEMNMLA-FIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAI-------------LFNNMLS 81
Cdd:MTH00196   5 GILCLISSSNWLSVYLAIELQTLSlFILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCallcgttgglhlsYINLVLN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  82 GQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPslNVSLLLTLSILS 161
Cdd:MTH00196  85 SGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL--NVNILLIGGLFS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 162 IMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTI----LNLTIYIILTTTAFLLLNLNSSTTTLL--LSRTWN 235
Cdd:MTH00196 163 LFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFESIqaslVYLFIYIIMSICVFSIILALNVYKNLIieFSGLSR 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 251831108 236 KLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLI 297
Cdd:MTH00196 243 RLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIV 304
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-268 3.35e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.52  E-value: 3.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   23 SSHWFFTWVGLEMNMLAFIPVLT-KKMNPRSTEAAIKYFLTQATASMILLMAIL----------FNNMLSGQWTMTNTTN 91
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISlmynytgtlsFDELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   92 Q-YSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLT-SGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMA----- 164
Cdd:pfam00361  81 LlLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPvSALLAATLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIismll 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  165 GSWGGLNQTQLRKILAYSSITHMGWMMAVL----PYNPNMTILNLTIYIILTTTAFLL-LNLNSSTTTLLLSRTWNKLTW 239
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCaGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 251831108  240 LTPLIPSTLLSLGGLP----PLTGFLPKWAIIE 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLaglpPTAGFLGKFLILA 273
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 7-297 1.03e-17

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 83.84  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108    7 PVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAF-IPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWT 85
Cdd:TIGR01770 105 YILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   86 MTNTTNQYSSLM------------IMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISP------ 147
Cdd:TIGR01770 185 FEDLLLFLSNGMlnisllllgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLyilfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  148 SLNVSLLLTLSILSIMA-GSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILtttaFLLLNLNSSTT 226
Cdd:TIGR01770 265 SEAWQIFLAIIAFLSMLiGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFI----YALMSLGAFGV 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  227 TLLLSRT---WNK-------LTWLTPLIPSTLLSLGGLPP----LTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYF 292
Cdd:TIGR01770 341 LSLLRSYkdeWIEyisdfagLFKTNPILAILILIFMFSLAgippLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFY 420


                  ....*
gi 251831108  293 YLRLI 297
Cdd:TIGR01770 421 YLRVV 425
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 15-221 1.38e-17

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 83.24  E-value: 1.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  15 AGTLITALSSHWFFTWVGLEMNMLA-FIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSG-----QWTMTN 88
Cdd:COG1007  113 LGMMLMASANDLLTLFLGLELLSLSlYVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGslnlaGIAAAL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  89 TTNQYSSLMIMMAMAM-------KLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQI-SPSLNVSLLLTLSIL 160
Cdd:COG1007  193 AAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlVEAFPGLAADWQLLL 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251831108 161 SIMA------GSWGGLNQTQLRKILAYSSITHMGWMM-AVLPYNPNM---TILNLTIYIILTTTAFLLLNL 221
Cdd:COG1007  273 AVLAvlsmtvGNLAALAQTNVKRMLAYSSIAHAGYLLlGLAAGTPLGvsaALFYLLAYLFMNLGAFAVILL 343
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
13-224 2.25e-14

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 73.70  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  13 IFAGTLITALsshwfftwVGLEMNMLA-FIPVLTKKMNPRSTEAAIKYFLTQATASMILL--MAILF----NNMLSGQWT 85
Cdd:PRK05777 120 VSANDLLTLF--------LGLELLSLPlYALAALRRDRRRSLEAAIKYFVLGALASGFLLygMSLLYgatgSLSFAGIAK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  86 MTNTTNQYSSL------MIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQI------SPSLNVSL 153
Cdd:PRK05777 192 ALADGSGNSLLllfglvFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvafgGLSEDWQQ 271

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 251831108 154 LLTLSILSIMA-GSWGGLNQTQLRKILAYSSITHMGWMM-AVLPYNPNM---TILNLTIYIILTTTAFLLLNLNSS 224
Cdd:PRK05777 272 VLAIIAIASMLvGNLAALSQTNIKRLLAYSSIAHAGYLLvGLAAGTAEGysaVLFYLLAYLFMTLGAFGVISLLRR 347
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 15-194 9.12e-10

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 59.39  E-value: 9.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  15 AGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYS 94
Cdd:COG0651  118 AGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMADLAARLA 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  95 SL----------MIMMAMAMKLGMAPFHFWVPEVTQGTP-----LTSGLLLltwqKLAPISIM---YQISPSLNVSLLLT 156
Cdd:COG0651  198 ELdpglllaafaLLLVGFGIKAALFPLHFWLPDAYPAAPspvsaLLSGLLT----KVGVYAILrvlTLLFGADPALFLGT 273

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 251831108 157 LSILSIMA----GSWGGLNQTQLRKILAYSSITHMGWMMAVL 194
Cdd:COG0651  274 LLLVLGLLtmlvGALGALAQRDLKRLLAYSSVSQIGYILLGL 315
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 16-191 1.27e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 56.41  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  16 GTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRST---------EAAIKYFLTQATASMILLM--AILFN------- 77
Cdd:MTH00198 200 GGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFgcALYFGftgnegm 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  78 --NMLSGQWTMTNTTNQYSSL---MIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMyqISPSLNVS 152
Cdd:MTH00198 280 lgTILSATLETTNIELRQGSLgylFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILL--TSLVITSK 357

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 251831108 153 LLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMM 191
Cdd:MTH00198 358 LLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 55-192 8.28e-08

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 53.55  E-value: 8.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  55 AAIKYFLTQATASMILLMAILFNNMLSGQWTM---TNTTNQYSS-------LMIMMAMAMKLGMAPFHFWVPEV-----T 119
Cdd:COG1008  162 AAIKFFLYTLAGSLLMLVAILALYFLAGALTFdiaELAAAPLPLtaqlllfLAFFIAFAVKVPMFPFHTWLPDAhveapT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 120 QGTPLTSGLLL----------------LTWQKLAP-------ISIMYqispslnvsllltlsilsimaGSWGGLNQTQLR 176
Cdd:COG1008  242 AGSVLLAGVLLkmggygllrfalplfpEASAYFAPllaalgvIGIIY---------------------GALVALAQTDLK 300

                        170
                 ....*....|....*.
gi 251831108 177 KILAYSSITHMGWMMA 192
Cdd:COG1008  301 RLIAYSSVSHMGFVLL 316
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 55-191 3.63e-07

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 51.48  E-value: 3.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108   55 AAIKYFLTQATASMILLMAILFNNMLSG---------QWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEV-----TQ 120
Cdd:TIGR01972 157 AAMKFFLYTLAGSLLMLLAILGLYFLGGgtfdllellNLPLPFGVQTWLFLAFFIAFAVKVPLFPLHTWLPDAhveapTA 236

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 251831108  121 GTPLTSGLLLltwqKLAPISIM---YQISPSLNVSLLLTLSILSIMA---GSWGGLNQTQLRKILAYSSITHMGWMM 191
Cdd:TIGR01972 237 GSVILAGVLL----KMGTYGFLrfnLPLFPDASLYFAPVLAALGVIAiiyGALIALAQTDIKRLIAYSSISHMGFVL 309
ndhB CHL00049
NADH dehydrogenase subunit 2
 51-221 8.41e-07

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 50.39  E-value: 8.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  51 RSTEAAIKYFLTQATASMILLMAI---------------LFNNMLSGQwtMTNTTNQYSSLM-IMMAMAMKLGMAPFHFW 114
Cdd:CHL00049 159 RSNEATMKYLLMGGASSSILVYGFswlyglsggeielqeIVNGLINTQ--MYNSPGISIALIfITVGIGFKLSLAPFHQW 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 115 VPEVTQGTPLTSGLLLLTWQKLA----PISIMYQISPSLNV---SLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHM 187
Cdd:CHL00049 237 TPDVYEGSPTPVVAFLSVTSKVAasalATRIFDIPFYFSSNewhLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQI 316

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 251831108 188 GWMM-AVLPYNPNMTILNLTIYIILtttaFLLLNL 221
Cdd:CHL00049 317 GYVIiGIIVGDSNDGYASMITYMLF----YIFMNL 347
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
47-191 1.01e-06

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 50.43  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  47 KMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQY----SSLMIMMAM-------AMKLGMAPFHFWV 115
Cdd:PRK02504 154 KRDPRSNEAALKYLLIGAASSAIFLYGSSLLYGLSGGSTQLSAIALAlitsPSLGLALALvfviagiAFKISAVPFHQWT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 116 PEVTQGTPLTSGLLLLTWQKLA----PISIMYQISPSLNVSLLLTLSILSIMAGSWG---GLNQTQLRKILAYSSITHMG 188
Cdd:PRK02504 234 PDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPSFDEQWKLLFTALAILSMVLGnvvALAQTSMKRMLAYSSIGQAG 313


                 ...
gi 251831108 189 WMM 191
Cdd:PRK02504 314 FVM 316
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-341 1.59e-05

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 41.86  E-value: 1.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 251831108  291 YFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISP 341
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 55-191 5.09e-05

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 44.81  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  55 AAIKYFLTQATASMILLMAILFnnMLSGQWTMTNTTNqYSSLM---------------IMMAMAMKLGMAPFHFWVPEV- 118
Cdd:PRK05846 162 AATKFFLYTLLGSLLMLVAIIY--LVVVYYNATGTFD-IADLLnlplppgvqywlflaFFIAFAVKMPMFPLHTWLPDAh 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 119 ----TQGTPLTSGLLLltwqKLAP---ISIMYQISPSLNVSLLLTLSILSIMA---GSWGGLNQTQLRKILAYSSITHMG 188
Cdd:PRK05846 239 vqapTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEFAPIIITLGVIAiiyGALVALAQTDIKKLIAYSSISHMG 314


                 ...
gi 251831108 189 WMM 191
Cdd:PRK05846 315 FVT 317
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 15-191 3.10e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 42.39  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  15 AGTLITALSSHWFFTWVGLEMNMLA-FIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAIlfnNMLSGQWTMTN----- 88
Cdd:PRK08376 132 LGMLGMAITGDLFNFFVFLEIMSIAsYALVAFRNDTWEAIEAGIKYMFVGSLASSMVLLGI---ALLYGQYGTLNmayla 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  89 ---TTNQYSSLMIMMA-----MAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTwQKLAPISIMYQIS-----PSLNVSL-- 153
Cdd:PRK08376 209 vkmSENPTVVAKIALAlfiagLAMKSGAVPVHMWLPDAYPAAPSSISAMLLV-IKQAGLYALARVLfsiygPAINLATvg 287

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 251831108 154 --LLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMM 191
Cdd:PRK08376 288 wvIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYML 327
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 54-188 3.87e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 42.22  E-value: 3.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  54 EAAIKYFLTQATASMILLMAI--LFN--------NMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTP 123
Cdd:MTH00226 182 QAAYYFFFYTLIGSVLMLLCLfsLYNihgttdylTLASCSHVVSEQTQKWIFLGIFLAMAVKIPIFPFHIWLPKAHVEAP 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 251831108 124 LTSGLLLL-TWQKLAPISIMYQISPSLNVSLLLTLSILSIMA------GSWGGLNQTQLRKILAYSSITHMG 188
Cdd:MTH00226 262 VAGSVLLAgILLKLGGYGLVRLSWPILPLGAQNLAPAVIAMGivgivyGSFATCRQIDVKRLVAYSSVAHMG 333
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 49-194 6.39e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 41.40  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108  49 NPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMT--------NTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQ 120
Cdd:PRK08375 151 DRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGTLNMAdlagalaeNPTVVTAFGFVLLALALKAAVFPLHTWLPRAYP 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831108 121 GTPLTSGLLLLTWQKLAPISIMYQIS---------PSLNVSLLLTLSILSIM-AGSWGGLNQTQLRKILAYSSITHMGWM 190
Cdd:PRK08375 231 AAPPVVTALLSGLVTKVAVYALIRIYftvfggdfrFALGLGWLLAVLALLSMlVGSLAALGQDDVKRVLAYSTVSQMGYI 310


                 ....
gi 251831108 191 MAVL 194
Cdd:PRK08375 311 LLGL 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH