NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|251831118|ref|YP_003024037|]
View 

NADH dehydrogenase subunit 6 (mitochondrion) [Homo sapiens]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.67e-81

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 238.55  E-value: 1.67e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|....
gi 251831118 161 FVGVYIVIEIARGN 174
Cdd:MTH00109 162 FIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.67e-81

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 238.55  E-value: 1.67e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|....
gi 251831118 161 FVGVYIVIEIARGN 174
Cdd:MTH00109 162 FIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 5.37e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.12  E-value: 5.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   17 VGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 251831118   97 AMEVGLVLWVKeydgvvvvvnFNSVGSWMIYEGEGSGLIREdpIGAGALYDYGrWLVVVTGWTLFVGVYIVIEI 170
Cdd:pfam00499  81 LLLALLLLVLL----------SASLTPAAAAAAPDVGNIEA--IGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.67e-81

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 238.55  E-value: 1.67e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|....
gi 251831118 161 FVGVYIVIEIARGN 174
Cdd:MTH00109 162 FIGVFVIIEITRGN 175
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 1.04e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 106.86  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSGVeVLVSVLVGLAMEVGLVLWVKEYDgvvvvvnfnSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL 160
Cdd:MTH00065  81 AWGSWS-VLVYVLFYLLLLIVGYILFGCNF---------SLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 251831118 161 FVGVYIVIEIARG 173
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 1.91e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 106.38  E-value: 1.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSG-VEVLVSVLVGLAMEVGLVLWVKEYDgvvvvvnfnsvGSW-MIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGW 158
Cdd:MTH00138  81 SWGSWsVLGYVVGYLVGVVLAAGLFWGGWYE-----------GSWvVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAW 149

                        170
                 ....*....|....*
gi 251831118 159 TLFVGVYIVIEIARG 173
Cdd:MTH00138 150 VLLLTLFVVLELTRG 164
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 1.33e-21

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 85.96  E-value: 1.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSgvevlVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWmiyEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL 160
Cdd:MTH00115  81 AWGD-----WGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTV---DSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|...
gi 251831118 161 FVGVYIVIEIARG 173
Cdd:MTH00115 153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 2.01e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 66.94  E-value: 2.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSGVEVLVSVLVGLamevglvlwvkeydGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLL--------------GLGFVGFYFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|...
gi 251831118 161 FVGVYIVIEIARG 173
Cdd:MTH00214 147 FLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-174 8.47e-13

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 62.62  E-value: 8.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   1 MMYALFLLSVGLVMGFVGFSSkpSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118  81 AWGSGvEVLVSVLVglamevgLVLWVkeydgvvvVVNFNSVGSWMIYEGEGSGLIREdpIGAGALYDYGRWLVVVTGWTL 160
Cdd:MTH00045  79 VSNLG-EVLVLSLL-------LSLWV--------FISFDNFLELSNNNWSLVSLSDL--VGSSELYNSGGLYLLLGGFIL 140

                        170
                 ....*....|....
gi 251831118 161 FVGVYIVIEIARGN 174
Cdd:MTH00045 141 LVALVVALVISFGH 154
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 5.37e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.12  E-value: 5.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251831118   17 VGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGL 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 251831118   97 AMEVGLVLWVKeydgvvvvvnFNSVGSWMIYEGEGSGLIREdpIGAGALYDYGrWLVVVTGWTLFVGVYIVIEI 170
Cdd:pfam00499  81 LLLALLLLVLL----------SASLTPAAAAAAPDVGNIEA--IGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 1-74 7.35e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 41.14  E-value: 7.35e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 251831118   1 MMYALFLLSVGLvmgfvgFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMA 74
Cdd:MTH00212   5 LLLSLLLLLMLL------FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS 72
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 2-74 6.13e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 38.33  E-value: 6.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251831118   2 MYALFLLSVGLVMGFVGFSSKpSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMA 74
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH