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Conserved domains on  [gi|476409106|ref|YP_007626740|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Tragelaphus strepsiceros]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.94e-41

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 8.94e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.94e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 8.94e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 3.93e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.50  E-value: 3.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106   3 LVYMNIMMAFAVSLTGLLmYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 476409106  83 NTYGTDYVQNLNLLKC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-97 6.66e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.42  E-value: 6.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106 12 FAVSLTGLLMyRSHLMSSLLCIEGMMLSlfVMAALTILNSHFTLAS--MMPIILLVFAACEAALGLSLLVMVSNTYGTDY 89
Cdd:COG0713  14 FAIGLYGVLT-RRNLIVVLMSIELMLNA--VNLNLVAFSRYLGDLDgqVFALFVIAVAAAEVAVGLAIIVALYRNRGTID 90


                ....*...
gi 476409106 90 VQNLNLLK 97
Cdd:COG0713  91 VDDLNELK 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.94e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 8.94e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 5.07e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 87.21  E-value: 5.07e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 7.81e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 86.56  E-value: 7.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.14e-19

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 76.18  E-value: 1.14e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 3.93e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.50  E-value: 3.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106   3 LVYMNIMMAFAVSLTGLLmYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 476409106  83 NTYGTDYVQNLNLLKC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 5-96 2.51e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 57.26  E-value: 2.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  5 YMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVSNT 84
Cdd:MTH00181  2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                        90
                ....*....|..
gi 476409106 85 YGTDYVQNLNLL 96
Cdd:MTH00181 82 HGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 3.29e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 49.53  E-value: 3.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 476409106 81 VSNTYGTDYVQNLNLLK 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.33e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 47.92  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMaaLTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00149  2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVS 79

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00149 80 LIRLHGNDYVSSLSSLKF 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 5.18e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 46.51  E-value: 5.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  8 IMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHFTLasMMPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00188  9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKEL--YLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                        90
                ....*....|.
gi 476409106 88 DYVQNLNLLKC 98
Cdd:MTH00188 87 DYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 5-92 8.63e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 45.53  E-value: 8.63e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  5 YMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMaaLTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVSNT 84
Cdd:MTH00162  4 LLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRS 81


                ....*...
gi 476409106 85 YGTDYVQN 92
Cdd:MTH00162 82 HGNDYFSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 5.12e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 41.28  E-value: 5.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106  1 MSLVYMNIMMAFAVSLTGLLMYRSHLMSSLLCIEGMMLSLFVMAALTILNSHfTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFAN-QVNGMLAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 476409106 81 VSNTYGTDYVQNLNLLKC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-97 6.66e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.42  E-value: 6.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476409106 12 FAVSLTGLLMyRSHLMSSLLCIEGMMLSlfVMAALTILNSHFTLAS--MMPIILLVFAACEAALGLSLLVMVSNTYGTDY 89
Cdd:COG0713  14 FAIGLYGVLT-RRNLIVVLMSIELMLNA--VNLNLVAFSRYLGDLDgqVFALFVIAVAAAEVAVGLAIIVALYRNRGTID 90


                ....*...
gi 476409106 90 VQNLNLLK 97
Cdd:COG0713  91 VDDLNELK 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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