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Conserved domains on  [gi|1381394830|ref|YP_009480333|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Bradypus tridactylus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 5.25e-59

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 181.54  E-value: 5.25e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830   1 MIYAMYVLSVVFVVGFIGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  81 VWGSNVVVFGGLLSGLLVEGLVVVLLLISDSTESMFcGFKYMEDWVVF-GGGEGFVREDYVGVSSLYSYGIWFMVMAGWV 159
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVF-NFNGLGDWVIYdTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|...
gi 1381394830 160 LFISVFVVVEVTR 172
Cdd:MTH00109  161 LFIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 5.25e-59

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 181.54  E-value: 5.25e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830   1 MIYAMYVLSVVFVVGFIGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  81 VWGSNVVVFGGLLSGLLVEGLVVVLLLISDSTESMFcGFKYMEDWVVF-GGGEGFVREDYVGVSSLYSYGIWFMVMAGWV 159
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVF-NFNGLGDWVIYdTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|...
gi 1381394830 160 LFISVFVVVEVTR 172
Cdd:MTH00109  161 LFIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-169 4.49e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 44.03  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  17 IGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAM-AIEEYPEVWGSNVVVFGGLLSG 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1381394830  96 LLVEGLVVVLLLISDStesmfcgfkymedWVVFGGGEGFVREDYVGVSSLYSYGIWFMVmAGWVLFISVFVVVE 169
Cdd:pfam00499  81 LLLALLLLVLLSASLT-------------PAAAAAAPDVGNIEAIGELLFTDYLLPFEL-ASVLLLVALVGAIV 140
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 5.25e-59

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 181.54  E-value: 5.25e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830   1 MIYAMYVLSVVFVVGFIGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  81 VWGSNVVVFGGLLSGLLVEGLVVVLLLISDSTESMFcGFKYMEDWVVF-GGGEGFVREDYVGVSSLYSYGIWFMVMAGWV 159
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVF-NFNGLGDWVIYdTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|...
gi 1381394830 160 LFISVFVVVEVTR 172
Cdd:MTH00109  161 LFIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 4.27e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 112.93  E-value: 4.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830   1 MIYAMYVLSVVFVVGFIGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  81 VWGSNVVVFGGLLSGLLVEGLVvvlllisdsteSMFCGFKYMEDWVVFGGGEGF--VREDYVGVSSLYSYGIWFMVMAGW 158
Cdd:MTH00138   81 SWGSWSVLGYVVGYLVGVVLAA-----------GLFWGGWYEGSWVVVDELKEFsvLRGDVGGVALMYSSGGGMLVICAW 149

                         170
                  ....*....|....
gi 1381394830 159 VLFISVFVVVEVTR 172
Cdd:MTH00138  150 VLLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 7.52e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 99.54  E-value: 7.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830   1 MIYAMYVLSVVFVVGFIGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  81 VWGSnVVVFGGLLSGLLVEGLVVVLLLISDSTESMFcgfkymedwVVFGGGEGFVREDYVGVSSLYSYGIWFMVMAGWVL 160
Cdd:MTH00065   81 AWGS-WSVLVYVLFYLLLLIVGYILFGCNFSLEFLF---------TNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|..
gi 1381394830 161 FISVFVVVEVTR 172
Cdd:MTH00065  151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 3.86e-21

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 84.80  E-value: 3.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830   1 MIYAMYVLSVVFVVGFIGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  81 VWGSNVVVFGGLLSGLLVEGLVVVLLLisdstesmFCGFKYMEDWVVFGGGEGFVREDYVGVSSLYSYGIWFMVMAGWVL 160
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVVGG--------LWGMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|..
gi 1381394830 161 FISVFVVVEVTR 172
Cdd:MTH00115  153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-174 3.13e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 66.55  E-value: 3.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830   1 MIYAMYVLSVVFVVGFIGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  81 VWGSNVVVFGGLLSGLLVEGLVVvlllisdstesMFCGFKYMEDWVVFGGGEGFvreDYVGVSSLYSYGIWFMVMAGWVL 160
Cdd:MTH00214   81 SWGGWSVLLFFLFYLLGLGFVGF-----------YFYGGWEMLSWMGVDEANNL---DLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|....
gi 1381394830 161 FISVFVVVEVTRSG 174
Cdd:MTH00214  147 FLVLFVVLELVRGL 160
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 46-172 3.10e-07

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 47.59  E-value: 3.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  46 FGGSFLGLMVFLVYLGGMLVVFGYTTAMAIEEYPEVWGSNVVVFGGLLSGLLVEGLVVVLLLISDSTESMFCGfkymedw 125
Cdd:MTH00045   44 LGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVSNLGEVLVLSLLLSLWVFISFDNFLELSNNNWSLVSL------- 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1381394830 126 vvfgggegfvrEDYVGVSSLYSYGIWFMVMAGWVLFISVFVVVEVTR 172
Cdd:MTH00045  117 -----------SDLVGSSELYNSGGLYLLLGGFILLVALVVALVISF 152
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-169 4.49e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 44.03  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381394830  17 IGFSCKPSPIYGGLGLIVGGGAGCGMVVGFGGSFLGLMVFLVYLGGMLVVFGYTTAM-AIEEYPEVWGSNVVVFGGLLSG 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1381394830  96 LLVEGLVVVLLLISDStesmfcgfkymedWVVFGGGEGFVREDYVGVSSLYSYGIWFMVmAGWVLFISVFVVVE 169
Cdd:pfam00499  81 LLLALLLLVLLSASLT-------------PAAAAAAPDVGNIEAIGELLFTDYLLPFEL-ASVLLLVALVGAIV 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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