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Conserved domains on  [gi|62184408|ref|YP_220652|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Latimeria menadoensis]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009582)

NADH dehydrogenase subunit 6 (mitochondrion) is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 18-173 4.54e-67

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 177196  Cd Length: 173  Bit Score: 201.91  E-value: 4.54e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   18 AVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPESWGSWSVFLYILVYFFG 97
Cdd:MTH00138  18 AVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPESWGSWSVLGYVVGYLVG 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62184408   98 FLFVGCCCYGWWYDFYWMSLDVFGEVSVLSGDVSGVSLVYSSGGFLLLVTGWVLLLTLFVVLEVTRGLSRGALRAV 173
Cdd:MTH00138  98 VVLAAGLFWGGWYEGSWVVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLELTRGLSRGALRAV 173
 
Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 18-173 4.54e-67

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 201.91  E-value: 4.54e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   18 AVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPESWGSWSVFLYILVYFFG 97
Cdd:MTH00138  18 AVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPESWGSWSVLGYVVGYLVG 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62184408   98 FLFVGCCCYGWWYDFYWMSLDVFGEVSVLSGDVSGVSLVYSSGGFLLLVTGWVLLLTLFVVLEVTRGLSRGALRAV 173
Cdd:MTH00138  98 VVLAAGLFWGGWYEGSWVVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLELTRGLSRGALRAV 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-102 3.31e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 3.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408    17 MAVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAAL-AAEPYPESWGSWSVFLYILVYF 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80


                  ....*..
gi 62184408    96 FGFLFVG 102
Cdd:pfam00499  81 LLLALLL 87
 
Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 18-173 4.54e-67

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 201.91  E-value: 4.54e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   18 AVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPESWGSWSVFLYILVYFFG 97
Cdd:MTH00138  18 AVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPESWGSWSVLGYVVGYLVG 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62184408   98 FLFVGCCCYGWWYDFYWMSLDVFGEVSVLSGDVSGVSLVYSSGGFLLLVTGWVLLLTLFVVLEVTRGLSRGALRAV 173
Cdd:MTH00138  98 VVLAAGLFWGGWYEGSWVVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLELTRGLSRGALRAV 173
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 2.37e-48

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 154.24  E-value: 2.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408    1 MIYFVFVVLVGLVVGLMAVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   81 SWGSWSVFLYILVYFFgFLFVGCCCYGWWYDFYWMSLDVFGEVSVLSGDVSGVSLVYSSGGFLLLVTGWVLLLTLFVVLE 160
Cdd:MTH00065  81 AWGSWSVLVYVLFYLL-LLIVGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLLLTLFVVLE 159

                        170
                 ....*....|...
gi 62184408  161 VTRGLSRGALRAV 173
Cdd:MTH00065 160 VTRGLSRGSLRAV 172
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 1.31e-37

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 127.17  E-value: 1.31e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408    1 MIYFVFVVLVGLVVGLMAVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   81 SWGSWSVFLYILVYFFGFLFVGCCCYGWW-YDFYWMSLDVFGEVSVLSGDVSGVSLVYSSGGFLLLVTGWVLLLTLFVVL 159
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWgMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGLLLTLFVVL 160

                        170
                 ....*....|....
gi 62184408  160 EVTRGLSRGALRAV 173
Cdd:MTH00115 161 ELVRGLSRGALRAF 174
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 3.42e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 110.46  E-value: 3.42e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408    1 MIYFVFVVLVGLVVGLMAVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   81 SWGSWSVFLYILVYFFGFLFVGCCCYGWWYDFYWMSLDVFGEVSvlsgdVSGVSLVYSSGGFLLLVTGWVLLLTLFVVLE 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDEANNLD-----LSGVSDLYSRGFFLLLLGGVVLFLVLFVVLE 155

                        170
                 ....*....|...
gi 62184408  161 VTRGLSRGALRAV 173
Cdd:MTH00214 156 LVRGLSRGALRVV 168
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 17-149 2.52e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 100.65  E-value: 2.52e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   17 MAVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPESWGSWSVFLYILVY-- 94
Cdd:MTH00109  18 VGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWVSNKVVLGALLLgl 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62184408   95 ----FFGFLFVGCCCYGWWYDF----YWMSLDVfGEVSVLSGDVSGVSLVYSSGGFLLLVTGW 149
Cdd:MTH00109  98 lmelLLVLYVLKDDEVEVVFNFnglgDWVIYDT-GGSGFFSEDAMGVAALYSYGTWLVVVTGW 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 25-172 3.61e-15

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 68.78  E-value: 3.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   25 PYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPES--WGSWSVFLYILVYFFGFLFvg 102
Cdd:MTH00045  23 PYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVsnLGEVLVLSLLLSLWVFISF-- 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408  103 cccygwwydFYWMSLDVFGEVSVLSGDVSGVSLVYSSGGFLLLVTGWVLLLTLFVVLEVTRGLSRGALRA 172
Cdd:MTH00045 101 ---------DNFLELSNNNWSLVSLSDLVGSSELYNSGGLYLLLGGFILLVALVVALVISFGHEYSSLRA 161
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-102 3.31e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 3.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408    17 MAVASNPAPYFAALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAAL-AAEPYPESWGSWSVFLYILVYF 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80


                  ....*..
gi 62184408    96 FGFLFVG 102
Cdd:pfam00499  81 LLLALLL 87
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 29-146 2.91e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 39.48  E-value: 2.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62184408   29 ALGLVFSAVVGCGFLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAA-EPYPESWGSWSVFLYILVYFFGFLFVGCCCYG 107
Cdd:MTH00152  27 GLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSPnPLFGSNFKFVFFSLTLFGFLGLFFFFLYLYSS 106

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 62184408  108 WWydfywmsLDVFGEVSVLSGDVSGVSLVYSSGGFLLLV 146
Cdd:MTH00152 107 GG-------LSLSSLFDGSSGSLSFGGGLYSSSGWSIFV 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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