BioProject

Diverse bacteria under stress conditions produce polyhydroxyalkanoates (PHAs) as intracellular storage granules. More...

Diverse bacteria under stress conditions produce polyhydroxyalkanoates (PHAs) as intracellular storage granules. The synthesis, accumulation and recovery of these biopolyesters from urban bio-waste (e.g., biomass of municipal solid waste) have attracted high biotechnological interest in recent years (e.g., PHA-based bioplastics). However, some PHA producers can be facultative human pathogens, which can give rise to concern. For instance, PHA-producing strains belonging to Brevundimonas are known, but Brevundimonas is a genus with emerging opportunistic pathogens. Recently, we isolated PHA-producing bacterial strains from a sequencing batch reactor (SRB) for the production of PHA (ResUrbis Project). In this study, we describe the draft genome sequence of the PHA-producing Brevundimonas diminuta TVB1, which resulted closely related to B. diminuta ATCC 11568. From the genomic data of B. diminuta TVB1, we detected genes of the PHA biosynthetic pathway, including phaA, phaB, PhaC, and PhaR. Elucidation of the PHA production pathways may provide new insight to improve the ongoing research on PHA biosynthesis. The genome also contains virulence factor genes suggesting an unknown role in virulence that needs to be investigated in terms of the evaluation of occupational safety issues. The costs for the Next Generation Sequencing (NGS) were supported by INAIL-DIT (PAR 2016-2018). Less...