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We applied metagenomic sequencing to respiratory and gastrointestinal tract specimens, collected from a cohort of long-term acute care hospital (LTACH) residents, in order to define microbiome and resistome change under antibiotic pressure, generate microbiome disruption indices (MDIs) to predict risk for multidrug-resistant infection, and contribute to a deeper understanding of how antibiotics and other medications increase risk of specific AMR gene selection and persistence.
| Accession | PRJNA546227 |
| Data Type | Raw sequence reads |
| Scope | Multispecies |
| Grants | - "Longitudinal analysis of respiratory tract microbiome change and sequence-based infection diagnosis during mechanical ventilation" (Grant ID K23 AI121485, National Institute of Allergy and Infectious Diseases Extramural Activities)
- "Longitudinal analysis of respiratory tract microbiome change and sequence-based infection diagnosis during mechanical ventilation" (Grant ID L30 AI120149, National Institute of Allergy and Infectious Diseases Extramural Activities)
- "Metagenomic and whole-genome sequencing to define resistome evolution during antibiotic exposure and long-term acute care" (Grant ID CDC BAA 200-2018-02919, Centers for Disease Control)
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| Submission | Registration date: 4-Jun-2019
University of Pennsylvania |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 335 |
| Other datasets |
| BioSample | 335 |