To study the tissue-specific evolution of regulatory elements and gene expression in the mammalian lineage, we created a comprehensive map of promoters and enhancers in 4 tissues of 10 mammalian species. To assay tissue-specific gene expression we performed RNA-seq experiments in adult liver, muscle, brain and testis of all 10 species. The species included in the study are: macaque, marmoset, mouse, rat, rabbit, pig, dog, cat, horse and opossum. To map in-vivo promoters and enhancers, we performed ChIP-seq experiments for H3K4me3, H3K27ac and H3K4me1 in all tissues and species and submitted these separately to ArrayExpress.
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