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We performed deep mutational scanning and related experiments on a collection of wildtype and mutated receptor-binding domains (RBDs) from a panel of SARS-related coronavirus isolates. We used these libraries to measure phenotypes such as binding to ACE2 orthologs or antibodies.
| Accession | PRJNA714677 |
| Data Type | Raw sequence reads |
| Scope | Multispecies |
| Publications | - Starr TN et al., "ACE2 binding is an ancestral and evolvable trait of sarbecoviruses.", Nature, 2022 Mar;603(7903):913-918
- Starr TN et al., "SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.", Nature, 2021 Sep;597(7874):97-102
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| Submission | Registration date: 15-Mar-2021
Fred Hutchinson Cancer Research Center |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 1249 |
| Publications |
| PubMed | 2 |
| PMC | 2 |
| Other datasets |
| BioSample | 6 |