Sex- and region-specific transcriptomic difference... (ID 597110) - BioProject

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Accession: PRJNA597110 ID: 597110

Sex- and region-specific transcriptomic differences in brainstem and cervical spinal cord microglia in rat offspring exposed to gestational intermittent hypoxia (Norway rat)

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We analyzed gene expression via RNA-sequencing in medulla and C3-C6 cervical spinal cord microglia isolated from young adult rats exposed to gestational intermittent normoxia or gestational intermittent hypoxia Overall design: G10 sprague dawley rat dams were exposed to one of the following conditions: 1) 11 days of intermittent normoxia (21%/21% O2) or 2) 11 days of intermittent hypoxia (21%/10. More...

Accession	PRJNA597110; GEO: GSE142478
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Rattus norvegicus[Taxonomy ID: 10116] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus
Publications	Ewald AC et al., "Sex- and Region-Specific Differences in the Transcriptomes of Rat Microglia from the Brainstem and Cervical Spinal Cord.", J Pharmacol Exp Ther, 2020 Oct;375(1):210-222
Grants	"The Role of TLR4 signaling and histone modifications in neonatal microglial priming by chronic intermittent hypoxia" (Grant ID F31 NS100229, National Institute of Neurological Disorders and Stroke) "Fetal reprogramming by gestational intermittent hypoxia impairs respiratory neuromotor control in adult offspring" (Grant ID R01 HL142752, National Heart, Lung, and Blood Institute) "Fetal reprogramming by gestational intermittent hypoxia impairs respiratory neuromotor control in adult offspring" (Grant ID R01 HL142752, National Heart, Lung, and Blood Institute)
Submission	Registration date: 20-Dec-2019 Watters, Comparative Biomedical Sciences, University of Wisconsin - Madison
Relevance	Model Organism

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	40
Publications
PubMed	1
PMC	1
Other datasets
BioSample	40
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	2

SRA Data Details

Parameter	Value
Data volume, Gbases	150
Data volume, Mbytes	45615

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Sex- and region-specific transcriptomic differences in brainstem and cervical spinal cord microglia in rat offspring exposed to gestational intermittent hypoxia (Norway rat)

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