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Genome Information for Homo sapiens
Acute Lymphoblastic Leukemia (ALL) in infants (<1 year of age) is characterized by a high incidence of MLL translocations which is associated with a poor prognosis. Contributing to this poor prognosis is cellular drug resistance, especially to glucocorticoids like prednisolone. Although in vitro prednisolone resistance mechanisms have been proposed in pediatric ALL, it has never been studied in MLL-rearranged infant ALL, which are highly resistant to glucocorticoids in vitro and in vivo.
Overall design: We analyzed primary MLL-rearranged infant ALL expression profiles, which were either in vitro prednisolone-resistant or prednisolone-sensitive, in order to study in vitro prednisolone resistance.
| Accession | PRJNA146413; GEO: GSE32962 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Spijkers-Hagelstein JA et al., "Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.", Leukemia, 2012 Jun;26(6):1255-65 |
| Submission | Registration date: 13-Oct-2011
Pediatric Oncology, ErasmusMC - Sophia's Childrens Hospital |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| Other datasets |
| GEO DataSets | 2 |
GEO Data Details| Parameter | Value |
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| Data volume, Spots | 2344231 |
| Data volume, Processed Mbytes | 51 |
| Data volume, Supplementary Mbytes | 214 |