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Genome Information for Homo sapiens
Gene expression profiling revealed over-representation of a distinct (proneural-like) expression signature in long-term survivors that was linked to IDH1/2 mutation. However, among the IDH1/2-wildtype patients, tumors from long-term survivors did not show distinct gene expression profiles and included proneural, classical and mesenchymal glioblastoma subtypes.
We performed genome- and/or transcriptome-wide molecular profiling of primary tumor samples from 70 glioblastoma patients of the German Glioma Network, including 23 longterm survivors with >36 months overall survival (OS), 16 short-term survivors with <12 months OS, and 31 patients with intermediate OS
Overall design: For this study, we screened prospectively recruited patients with a histopathological reference diagnosis of glioblastoma, known KPS at diagnosis, information on extent of resection by early postoperative neuroimaging, available frozen tissue specimens from the initial operation, and documented clinical outcome.
Accession | PRJNA232732; GEO: GSE53733 |
Data Type | Transcriptome or Gene expression |
Scope | Multiisolate |
Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
Publications | Reifenberger G et al., "Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling.", Int J Cancer, 2014 Oct 15;135(8):1822-31 |
Submission | Registration date: 30-Dec-2013 IZBI |
Relevance | Medical |
Project Data:
Resource Name | Number of Links |
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Publications |
PubMed | 1 |
Other datasets |
GEO DataSets | 2 |
GEO Data DetailsParameter | Value |
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Data volume, Spots | 3827250 |
Data volume, Processed Mbytes | 85 |
Data volume, Supplementary Mbytes | 331 |