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The cell line (also known as D6BE-ER2-9) is a derivative of the SV40 Transformed immortalized version of the primary xeroderma pigmentosum fibroblast complementation group D fibroblast GM08207 (XP6BE);which was subsequently transfected with p2E-ER2;a complementary DNA expression construct of the ERCC2 (XPD) gene;to correct the abnormal phenotype;GM15877 shows normal cellular resistance to UV irradiation;normal DNA repair of damaged shuttle vector plasmid and restoration of transcription of a UV damaged CAT expression vector;the XPD protein expression is about 18 fold greater than in the SV40 Transformed parent ( Gozukara et al;Cancer Res;54:3837-44;1994);the corrected phenotype of GM15877 requires selection with 0.6mg/ml of Geneticin (G418)
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