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Metagenome-assembled genome: ERR1190843_bin.91_CONCOCT_v1.1_MAG

Identifiers
BioSample: SAMEA14083360; SRA: ERS11686494
Organism
uncultured Opitutales bacterium
cellular organisms; Bacteria; PVC group; Verrucomicrobiota; Opitutia; Opitutales; environmental samples
Attributes
collection date2014-01-01
broad-scale environmental contextHost-associated
local-scale environmental contextHuman
environmental mediumDigestive system
geographic locationChina
investigation typemetagenome-assembled genome
isolation sourcehuman gut metagenome
project nameDysbosis of intestinal microbiota could contribute to the pathogenesis of Type 2 Diabetes. It is yet to be known whether intestinal flora could be related to differential responds to antidiabetic therapies. This study, herein for the first time, metagenomic sequenced fecal samples from a randomized clinical trial on new onset untreated Type 2 Diabetes patients applied two treatment arms, Acarbose and Glipizide (Sulfonylurea) and analyzed the differential responses of intestinal flora in different groups. Results showed substantial impact of Acarbose on gut microbiota community but minor of Glipizide. Enterotypes with similar baseline clinical characteristics, had significant different pharmacologic respond to Acarbose on insulin resistance, gut hormones, bile acids and cardiovascular risks, indicating that different pattern of intestinal microbiota component could determine different responses of Type 2 Diabetes to antidiabetic pharmacological therapies.
sample nameERR1190843_bin.91_CONCOCT_v1.1_MAG
ENA-CHECKLISTERC000047
ENA-FIRST-PUBLIC2023-01-03
ENA-LAST-UPDATE2023-01-03
External IdSAMEA14083360
INSDC center aliasEBI
INSDC center nameEuropean Bioinformatics Institute
INSDC first public2023-01-03T00:33:11Z
INSDC last update2023-01-03T00:33:11Z
INSDC statuspublic
Submitter IdERR1190843_bin.91_CONCOCT_v1.1_MAG
assembly qualityMany fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly softwarespades_v3.11.1
binning parametersDefault
binning softwareCONCOCT v1.1
broker nameEMG broker account, EMBL-EBI
completeness score85.17
completeness softwareCheckM
contamination score5.03
geographic location (latitude)55.676098
geographic location (longitude)12.568337
metagenomic sourcehuman gut metagenome
sample derived fromSAMEA3708769
scientific_nameuncultured Opitutales bacterium
sequencing methodIllumina HiSeq 2500
taxonomic identity markermulti-marker approach
Description

This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run ERR1190843 of study ERP013563.

BioProject
PRJEB51075 Large-scale analysis of novel cellular microbes from the human gut biome
Retrieve all samples from this project

Submission
EBI; 2023-01-04
Accession:
SAMEA14083360
ID:
32559976

BioProject Nucleotide

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