Metagenome-assembled genome: ERR1190927_bin.5_CONC... - BioSample

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Metagenome-assembled genome: ERR1190927_bin.5_CONCOCT_v1.1_MAG

Identifiers: BioSample: SAMEA14083394; SRA: ERS11686528

Organism: uncultured Collinsella sp.
cellular organisms; Bacteria; Bacillati; Actinomycetota; Coriobacteriia; Coriobacteriales; Coriobacteriaceae; Collinsella; environmental samples

Attributes

collection date	2014-01-01
broad-scale environmental context	Host-associated
local-scale environmental context	Human
environmental medium	Digestive system
geographic location	China
investigation type	metagenome-assembled genome
isolation source	human gut metagenome
project name	Dysbosis of intestinal microbiota could contribute to the pathogenesis of Type 2 Diabetes. It is yet to be known whether intestinal flora could be related to differential responds to antidiabetic therapies. This study, herein for the first time, metagenomic sequenced fecal samples from a randomized clinical trial on new onset untreated Type 2 Diabetes patients applied two treatment arms, Acarbose and Glipizide (Sulfonylurea) and analyzed the differential responses of intestinal flora in different groups. Results showed substantial impact of Acarbose on gut microbiota community but minor of Glipizide. Enterotypes with similar baseline clinical characteristics, had significant different pharmacologic respond to Acarbose on insulin resistance, gut hormones, bile acids and cardiovascular risks, indicating that different pattern of intestinal microbiota component could determine different responses of Type 2 Diabetes to antidiabetic pharmacological therapies.
sample name	ERR1190927_bin.5_CONCOCT_v1.1_MAG
ENA-CHECKLIST	ERC000047
ENA-FIRST-PUBLIC	2023-01-03
ENA-LAST-UPDATE	2023-01-03
External Id	SAMEA14083394
INSDC center alias	EBI
INSDC center name	European Bioinformatics Institute
INSDC first public	2023-01-03T00:33:27Z
INSDC last update	2023-01-03T00:33:27Z
INSDC status	public
Submitter Id	ERR1190927_bin.5_CONCOCT_v1.1_MAG
assembly quality	Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software	spades_v3.11.1
binning parameters	Default
binning software	CONCOCT v1.1
broker name	EMG broker account, EMBL-EBI
completeness score	100
completeness software	CheckM
contamination score	2.9
geographic location (latitude)	55.676098
geographic location (longitude)	12.568337
metagenomic source	human gut metagenome
sample derived from	SAMEA3708853
scientific_name	uncultured Collinsella sp.
sequencing method	Illumina HiSeq 2500
taxonomic identity marker	multi-marker approach

Description: This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run ERR1190927 of study ERP013563.