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Select item 105310501.

Clinical Targeted Next-Generation Panel Sequencing Reveals MYC Amplification Is a Poor Prognostic Factor in Osteosarcoma

Amanda E. Marinoff, Liam F. Spurr, Christina Fong, Yvonne Y. Li, Suzanne J. Forrest, Abigail Ward, Duong Doan, Laura Corson, Audrey Mauguen, Navin Pinto, Luke Maese, Susan Colace, Margaret E. Macy, AeRang Kim, Amit J. Sabnis, Mark A. Applebaum, Theodore W. Laetsch, Julia Glade-Bender, Daniel A. Weiser, Megan Anderson, Brian D. Crompton, Paul Meyers, Ahmet Zehir, Laura MacConaill, Neal Lindeman, Jonathan A. Nowak, Marc Ladanyi, Alanna J. Church, Andrew D. Cherniack, Neerav Shukla, Katherine A. Janeway

JCO Precis Oncol. 2023; 7: e2200334. Published online 2023 Mar 30. doi: 10.1200/PO.22.00334

PMCID:: PMC10531050

Abstract Article PDF–1.1M

Select item 104302372.

Palliative Radiotherapy for Children: Symptom Response and Treatment Associated Toxicity According to RT Dose and Fractionation

Lisa J. Sudmeier, Nicholas Madden, Chao Zhang, Katharine Brock, Natia Esiashvili, Bree Eaton

Pediatr Blood Cancer. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Pediatr Blood Cancer. 2023 Apr; 70(4): e30195. Published online 2023 Jan 15. doi: 10.1002/pbc.30195

PMCID:: PMC10430237

Abstract Article PDF–109K

Select item 96318063.

Phase 2 Study of Anti-Disialoganglioside Antibody, Dinutuximab, in Combination with GM-CSF in Patients with Recurrent Osteosarcoma: A Report from the Children’s Oncology Group

Pooja Hingorani, Mark Krailo, Allen Buxton, Paul Hutson, Paul M. Sondel, Mitchell Diccianni, Alice Yu, Carol D. Morris, Richard B. Womer, Brian Crompton, R Lor Randall, Lisa A. Teot, Steven G. DuBois, Katherine A. Janeway, Richard G. Gorlick, Michael S. Isakoff

Eur J Cancer. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Eur J Cancer. 2022 Sep; 172: 264–275. Published online 2022 Jul 6. doi: 10.1016/j.ejca.2022.05.035

PMCID:: PMC9631806

Abstract Article PDF–844K

Select item 95497294.

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

Alexandre de Nonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli

EMBO Mol Med. 2022 Oct; 14(10): e15859. Published online 2022 Aug 3. doi: 10.15252/emmm.202215859

PMCID:: PMC9549729

Abstract Article PDF–15M

Select item 92733765.

Actionable Tumor Alterations and Treatment Protocol Enrollment of Pediatric and Young Adult Patients With Refractory Cancers in the National Cancer Institute–Children's Oncology Group Pediatric MATCH Trial

D. Williams Parsons, Katherine A. Janeway, David R. Patton, Cynthia L. Winter, Brent Coffey, P. Mickey Williams, Sinchita Roy-Chowdhuri, Gregory J. Tsongalis, Mark Routbort, Nilsa C. Ramirez, Lauren Saguilig, Jin Piao, Todd A. Alonzo, Stacey L. Berg, Elizabeth Fox, Douglas S. Hawkins, Jeffrey S. Abrams, Margaret Mooney, Naoko Takebe, James V. Tricoli, Nita L. Seibel

J Clin Oncol. 2022 Jul 10; 40(20): 2224–2234. Published online 2022 Mar 30. doi: 10.1200/JCO.21.02838

PMCID:: PMC9273376

Abstract Article PDF–737K

Select item 92008186.

Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets

Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh A. Smith, Cristina R. Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas D. Socci, Satshil Rana, Rodrigo Gularte-Mérida, Ahmet Zehir, Mrinal M. Gounder, Timothy G. Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan A. Strong, Jake Stoller, Jason E. Chan, Ping Chi, Sandra P. D’Angelo, Mark A. Dickson, Ciara M. Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul A. Meyers, Leonard H. Wexler, Emily K. Slotkin, Julia L. Glade Bender, Neerav N. Shukla, Martee L. Hensley, John H. Healey, Michael P. La Quaglia, Kaled M. Alektiar, Aimee M. Crago, Sam S. Yoon, Brian R. Untch, Sarah Chiang, Narasimhan P. Agaram, Meera R. Hameed, Michael F. Berger, David B. Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer, William D. Tap

Nat Commun. 2022; 13: 3405. Published online 2022 Jun 15. doi: 10.1038/s41467-022-30453-x

PMCID:: PMC9200818

Abstract Article PDF–21M

Select item 87636167.

Cabozantinib in Advanced Ewing Sarcomas and osteosarcomas: a multicentre, single-arm, phase 2 trial

Antoine ITALIANO, Olivier MIR, Simone MATHOULIN-PELISSIER, Nicolas PENEL, Sophie PIPERNO-NEUMANN, Emmanuelle BOMPAS, Christine CHEVREAU, Florence DUFFAUD, Natacha ENTZ-WERLÉ, Esma SAADA, Isabelle RAY-COQUARD, Cyril LERVAT, Nathalie GASPAR, Perrine MAREC-BERARD, Hélène PACQUEMENT, John WRIGHT, Maud TOULMONDE, Alban BESSEDE, Amandine CROMBE, Michèle KIND, Carine BELLERA, Jean-Yves BLAY

Lancet Oncol. Author manuscript; available in PMC 2022 Jan 17.

Published in final edited form as: Lancet Oncol. 2020 Mar; 21(3): 446–455. Published online 2020 Feb 17. doi: 10.1016/S1470-2045(19)30825-3

PMCID:: PMC8763616

Abstract Article PDF–1.1M

Select item 83639288.

MYC amplifications are common events in childhood osteosarcoma

Solange De Noon, Jannat Ijaz, Tim HH Coorens, Fernanda Amary, Hongtao Ye, Anna Strobl, Iben Lyskjær, Adrienne M Flanagan, Sam Behjati

J Pathol Clin Res. 2021 Sep; 7(5): 425–431. Published online 2021 May 9. doi: 10.1002/cjp2.219

PMCID:: PMC8363928

Abstract Article PDF–892K

Select item 83608879.

Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial

Kjetil Boye, Alessandra Longhi, Tormod Guren, Susanne Lorenz, Stine Næss, Michela Pierini, Ingeborg Taksdal, Ingvild Lobmaier, Marilena Cesari, Anna Paioli, Ayca M. Løndalen, Elisabetta Setola, Ivar Hompland, Leonardo A. Meza-Zepeda, Kirsten Sundby Hall, Emanuela Palmerini

Cancer Immunol Immunother. 2021 Sep; 70(9): 2617–2624. Published online 2021 Feb 12. doi: 10.1007/s00262-021-02876-w

PMCID:: PMC8360887

Abstract Article PDF–1.2M

Select item 793902910.

Pembrolizumab in Advanced Soft Tissue and Bone Sarcomas: Results of SARC028, A Multicentre, Single arm, Phase 2 Trial

Hussein A. Tawbi, Melissa Burgess, Vanessa Bolejack, Brain A. Van Tine, Scott M. Schuetze, James Hu, Sandra D’Angelo, Steven Attia, Richard F. Riedel, Dennis A. Priebat, Sujana Movva, Lara E. Davis, Scott H. Okuno, Damon R. Reed, John Crowley, Lisa H. Butterfield, Ruth Salazar, Jaime Rodriguez-Canales, Alexander J. Lazar, Ignacio I. Wistuba, Laurence H. Baker, Robert G. Maki, Denise Reinke, Shreyaskumar Patel

Lancet Oncol. Author manuscript; available in PMC 2021 Mar 8.

Published in final edited form as: Lancet Oncol. 2017 Nov; 18(11): 1493–1501. Published online 2017 Oct 4. doi: 10.1016/S1470-2045(17)30624-1

PMCID:: PMC7939029

Abstract Article PDF–905K

Select item 779944311.

Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma

Lara E. Davis, Vanessa Bolejack, Christopher W. Ryan, Kristen N. Ganjoo, Elizabeth T. Loggers, Sant Chawla, Mark Agulnik, Michael B. Livingston, Damon Reed, Vicky Keedy, Daniel Rushing, Scott Okuno, Denise K. Reinke, Richard F. Riedel, Steven Attia, Leo Mascarenhas, Robert G. Maki

J Clin Oncol. 2019 Jun 1; 37(16): 1424–1431. Published online 2019 Apr 23. doi: 10.1200/JCO.18.02374

PMCID:: PMC7799443

Abstract Article PDF–947K

Select item 777471812.

Clinical outcomes of non‐osteogenic, non‐Ewing soft‐tissue sarcoma of bone––experience of the Toronto Sarcoma Program

Zachary W. Veitch, Samir Fasih, Anthony M. Griffin, Esmail M. Al‐Ezzi, Abha A. Gupta, Peter C. Ferguson, Jay S. Wunder, Albiruni R. Abdul Razak

Cancer Med. 2020 Dec; 9(24): 9282–9292. Published online 2020 Oct 16. doi: 10.1002/cam4.3531

PMCID:: PMC7774718

Abstract Article PDF–785K

Select item 769209813.

High Dose Ifosfamide in Relapsed and Unresectable High-Grade Osteosarcoma Patients: A Retrospective Series

Emanuela Palmerini, Elisabetta Setola, Giovanni Grignani, Lorenzo D’Ambrosio, Alessandro Comandone, Alberto Righi, Alessandra Longhi, Marilena Cesari, Anna Paioli, Rossella Hakim, Michela Pierini, Emanuela Marchesi, Daniel Vanel, Ymera Pignochino, Davide Maria Donati, Piero Picci, Stefano Ferrari

Cells. 2020 Nov; 9(11): 2389. Published online 2020 Oct 31. doi: 10.3390/cells9112389

PMCID:: PMC7692098

Abstract Article PDF–655K

Select item 749768814.

Retrospective review of the activity and safety of apatinib and anlotinib in patients with advanced osteosarcoma and soft tissue sarcoma

Zhichao Tian, Huimin Liu, Fan Zhang, Liangyu Li, Xinhui Du, Chao Li, Jinpo Yang, Jiaqiang Wang

Invest New Drugs. 2020; 38(5): 1559–1569. Published online 2020 Feb 25. doi: 10.1007/s10637-020-00912-7

PMCID:: PMC7497688

Abstract Article PDF–625K

Select item 708276915.

Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma

Lisa Mirabello, Bin Zhu, Roelof Koster, Eric Karlins, Michael Dean, Meredith Yeager, Matthew Gianferante, Logan G. Spector, Lindsay M. Morton, Danielle Karyadi, Leslie L. Robison, Gregory T. Armstrong, Smita Bhatia, Lei Song, Nathan Pankratz, Maisa Pinheiro, Julie M. Gastier-Foster, Richard Gorlick, Silvia Regina Caminada de Toledo, Antonio S. Petrilli, Ana Patino-Garcia, Fernando Lecanda, Miriam Gutierrez-Jimeno, Massimo Serra, Claudia Hattinger, Piero Picci, Katia Scotlandi, Adrienne M. Flanagan, Roberto Tirabosco, Maria Fernanda Amary, Nilgün Kurucu, Inci Ergurhan Ilhan, Mandy L. Ballinger, David M. Thomas, Donald A. Barkauskas, Gerardo Mejia-Baltodano, Patricia Valverde, Belynda D. Hicks, Bin Zhu, Mingyi Wang, Amy A. Hutchinson, Margaret Tucker, Joshua Sampson, Maria T. Landi, Neal D. Freedman, Susan Gapstur, Brian Carter, Robert N. Hoover, Stephen J. Chanock, Sharon A. Savage

JAMA Oncol. 2020 May; 6(5): 724–734. Published online 2020 Mar 19. doi: 10.1001/jamaoncol.2020.0197

PMCID:: PMC7082769

Abstract Article

Select item 699318516.

Risk-Based Therapy for Localized Osteosarcoma

Rajkumar Venkatramani, Jeffrey Murray, Lee Helman, William Meyer, M. John Hicks, Robert Krance, Ching Lau, Eunji Jo, Murali Chintagumpala

Pediatr Blood Cancer. Author manuscript; available in PMC 2020 Jan 31.

Published in final edited form as: Pediatr Blood Cancer. 2016 Mar; 63(3): 412–417. Published online 2015 Oct 26. doi: 10.1002/pbc.25808

PMCID:: PMC6993185

Abstract Article PDF–300K

Select item 682553417.

Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations

Yoshiyuki Suehara, Deepu Alex, Anita Bowman, Sumit Middha, Ahmet Zehir, Debyani Chakravarty, Lu Wang, George Jour, Khedoudja Nafa, Takuo Hayashi, Achim A Jungbluth, Denise Frosina, Emily Slotkin, Neerav Shukla, Paul Meyers, John H. Healey, Meera Hameed, Marc Ladanyi

Clin Cancer Res. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Clin Cancer Res. 2019 Nov 1; 25(21): 6346–6356. Published online 2019 Jun 7. doi: 10.1158/1078-0432.CCR-18-4032

PMCID:: PMC6825534

Abstract Article PDF–1.5M

Select item 682425718.

Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma

Jamie L. Maciaszek, Ninad Oak, Wenan Chen, Kayla V. Hamilton, Rose B. McGee, Regina Nuccio, Roya Mostafavi, Stacy Hines-Dowell, Lynn Harrison, Leslie Taylor, Elsie L. Gerhardt, Annastasia Ouma, Michael N. Edmonson, Aman Patel, Joy Nakitandwe, Alberto S. Pappo, Elizabeth M. Azzato, Sheila A. Shurtleff, David W. Ellison, James R. Downing, Melissa M. Hudson, Leslie L. Robison, Victor Santana, Scott Newman, Jinghui Zhang, Zhaoming Wang, Gang Wu, Kim E. Nichols, Chimene A. Kesserwan

Cold Spring Harb Mol Case Stud. 2019 Oct; 5(5): a004218. doi: 10.1101/mcs.a004218