Genetic diagnostic rates in 1,119 sequentially accrued persons with hearing loss. No person was excluded based on phenotype, inheritance, or previous testing. Testing resulted in identification of the underlying genetic cause for hearing loss in 440 individuals (39%). Pathogenic variants were found in 49 genes and included missense variants, large copy number changes, small insertions and deletions, nonsense variants, splice-site alterations, and promoter variants. Note that the diagnostic rate for GJB2-related deafness varies based on ethnicity [Sloan-Heggen et al 2016].