Figure 1. . Estimated probability of a severe outcome (95% CI) for an individual with the mtDNA m.

Figure 1.

Estimated probability of a severe outcome (95% CI) for an individual with the mtDNA m.8993T>G or m.8993T>C variant, based on the proportion of abnormal mtDNA (mutant load) in the individual. A severe outcome is defined as severe symptoms of NARP or Leigh syndrome and probability is calculated using a logistic regression model described in White et al [1999a]. Note that the risk of developing severe symptoms is minimal: below the approximate threshold values of 50% for m.8993T>G and 75% for m.8993T>C.

From: Mitochondrial DNA-Associated Leigh Syndrome and NARP

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