Table 2.

Cardiofaciocutaneous Syndrome: Frequency of Select Features

Nearly allCommonLess frequent
Prenatal polyhydramnios
Characteristic facial features
Cardiac issues
Feeding difficulties
Poor growth
Skin issues
Neurocognitive delaysRanging from mild to profound
Eye anomalies
Musculoskeletal abnormalities
Hypotonia & motor developmental delay
Behavioral issues
Neonatal chylothorax &/or lymphedema
Otolaryngologic issuesMost commonly recurrent otitis media
Urogenital anomaliesMost commonly cryptorchidism in males
Hematologic issue
Immunologic issues

From: Cardiofaciocutaneous Syndrome

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