Table 4.

Recommended Evaluations Following Initial Diagnosis in Individuals with Hereditary Transthyretin (ATTR) Amyloidosis

Neurologic Complete neurologic assessment incl baseline nerve conduction studies
Cardiac EchocardiogramTo evaluate ventricular wall thickness, ventricular septal thickness, diastolic & systolic function, & longitudinal strain
ElectrocardiogramTo evaluate for low voltage in the standard limb leads & QS pattern in the right precordial leads w/ or w/out conduction blocks
Myocardial technetium-99m-pyrophosphate scintigraphyTo visualize amyloid deposition in heart
  • Gadolinium-enhanced MRI of brain & spinal cord
  • Amyloid PET imaging using PiB
To evaluate CNS amyloidosis
Ophthalmologic Ophthalmologic evalEvaluate for vitreous opacities & glaucoma.
Nephrologic Routine blood & urine exams for eval of renal function
Other Consultation w/clinical geneticist &/or genetic counselor

PiB = Pittsburgh compound B

From: Hereditary Transthyretin Amyloidosis

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