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Adam MP, Mirzaa GM, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2023.

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Figure 1. . The position of pathogenic variants in NF2 affects the likelihood of developing a meningioma.

Figure 1.

The position of pathogenic variants in NF2 affects the likelihood of developing a meningioma.

A. The Kaplan-Meier plot shows the risk of meningioma within each functional domain. Gene regions are divided into exons 1-3, 4-6, 7-9, 10-13, and 14-15.

B. The bar graph shows the overall risk for meningioma conferred by pathogenic variants in individual exons. 5' regions confer a higher risk than 3' regions, and exons encoding the junctions between functional domains confer a higher relative risk than the rest of the domain.

From: NF2-Related Schwannomatosis

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