Table 2.

Select Features of the Four Most Common EBS Subtypes

Clinical FeaturesEBS Subtype
LocalizedIntermediateSevereW/mottled pigmentation
Age of onset Infancy, usually by 12-18 mosBirth/infancyBirthBirth/infancy
  • Blisters usually limited to hands, feet; can occur at sites of repeated trauma
  • Rare mucosal blisters
  • Generalized
  • Occasional mucosal blisters
  • Generalized
  • Grouped (herpetiform) blisters
  • Mucosal blisters
  • Generalized
  • ± grouped (herpetiform) blisters
  • ± mucosal blisters
of palms & soles
OccasionallyOccasionallyCommon, progressive, & diffuseCommon, focal
Nail involvement OccasionallyOccasionallyCommonOccasionally
Milia RareOccasionallyCommonUnknown
NoCan occurCommonAlways

From: Epidermolysis Bullosa Simplex

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